RX Imola: Inflammatory Biomarkers in COVID-19
RX Imola: Inflammatory Biomarkers in COVID-19
Over the course of human history, few events have had such a dramatic impact as the COVID-19 pandemic. According to the World Health Organization (WHO), as of 12th July 2023, the SARS-CoV-2 virus has claimed almost 7 million lives and figures continue to rise1. While many who become infected are only subject to mild symptoms, those who develop a more severe form of the infection are encumbered with a debilitating flu-like condition, often requiring days, if not weeks of bed rest. In a paper from June 20232, the Rx Imola was used to study C reactive protein concentrations, along with other biomarkers, in mild and severe COVID-19 patients in order to develop novel risk stratification methods for this potentially life-threatening viral infection.
The impact on healthcare services around the world cannot be understated. In developed countries, access to services for both COVID-related and other conditions took a catastrophic hit. In low-to-middle-income countries, the impact has been even more distressing, all but eliminating basic medical care in favour of combating COVID-19, partly due to inferior resources and facilities3.
In times of medical emergency, it is crucial to have an efficient and effective means of stratifying the risk to patients and a process for suitably categorising those into the least and most at risk of severe complications or death. Due to the rate at which COVID-19 spread, unfortunately, the world lacked these mechanisms for SARS-CoV-2, resulting in mass hospital overpopulation, cancelled appointments for other life-threatening conditions and ultimately the staggering mortality statistics we’ve been bombarded with since January 2022. This prompted an unprecedented surge in medical research and major advances in testing capabilities, giving us new methods of detecting SARS-CoV-2 and determining the risk posed to individuals.
One such investigation, by Paranga et al., (2023) studied a total of 13 biomarkers to determine which could accurately differentiate mild, moderate, and severe cases and identify biomarkers which were good predictors of fatality2. C reactive protein (CRP) was the best-described biomarker relating to COVID-19 throughout the pandemic. This paper compares it to 12 other biomarkers including suPAR, sTREM-1, ferritin, MCP-1 and Lactate dehydrogenase. Of these, it was discovered that CRP was clearly the most effective biomarker for differentiating mild from severe cases, with concentrations in those with severe infection being, on average, 45% higher than in those with mild symptoms2. Additionally, the authors discovered that CRP levels were not significantly affected by age, a factor known to affect the inflammation and immune responses, providing a powerful and inclusive risk stratification tool. Some of the additional conclusions drawn from this paper can be seen below2:
- Lactate dehydrogenase, sTREM-1 and HGF were good predictors of mortality in COVID-19.
- suPAR was identified as a crucial molecule in characterising Delta variant infection and mortality.
- The initial values of inflammatory biomarkers were good to excellent predictors of disease severity in COVID-19 patients.
- Disease severity and mortality are associated with a higher rate of comorbidities including thrombocytopenia and other blood diseases, circulatory and respiratory system diseases and liver diseases such as cirrhosis.
So, what is CRP and how does it become elevated in response to a SARS-CoV-2 infection? CRP is a non-specific, acute-phase protein, meaning its concentration is altered in response to inflammation4. The acute respiratory distress syndrome induced by SARS-CoV-2 is, in part, a result of the hyperinflammation caused by the virus2. CRP is a well-characterised inflammatory biomarker and is therefore well-suited for identification and risk stratification in an emerging disease.
This investigation2 utilised the RX Imola, a rapid, comprehensive clinical chemistry platform, to quantify CRP. With the RX Imola, laboratories can gain access to the world’s largest clinical chemistry test menu covering routine chemistries as well as specific proteins, lipids, and more providing a cost-effective and user-friendly platform. With 60 cooled reagent positions and a sample carousel with 20 cooled positions for controls and calibrators, the RX Imola is an ideal solution for small to medium-throughput laboratories seeking an innovative and reliable clinical chemistry system. Randox also supplies suitable, high-quality reagents, and through Acusera, state-of-the-art controls and calibrators, completing the clinical chemistry portfolio.
References
1. World Health Organisation. WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int/.
2. Paranga TG, Pavel-Tanasa M, Constantinescu D, et al. Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants. Front Immunol. 2023;14. doi:10.3389/fimmu.2023.1213246
3. Jain P. Impact of COVID-19 Pandemic on Global Healthcare Systems and the role of a new era of global collaborations. Sushruta Journal of Health Policy & Opinion. 2021;14(3):1-5. doi:10.38192/14.3.2
4. Nehring S. C Reactive Protein . https://www.statpearls.com/articlelibrary/viewarticle/18744/.
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The Randox veterinary diagnostic solutions are scientifically proven and validated for use with a diverse range of animal species.
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Encompassing diagnostic reagents, internal & external quality control, and the RX series of clinical chemistry analysers.
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Offering the world’s largest veterinary test menu, the RX series provides laboratories with maximum analyser up-time combined with precise, reliable and accurate results. With a diverse range of versatile semi-automated and fully automated analysers, the RX series suits the needs of all laboratory sizes with unrivalled correlation to gold-standard methodologies.
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Offering an extensive veterinary test menu, encompassing 48 open channel diagnostic assays which are internationally recognised as being of the highest quality, producing accurate and precise results. All our assays are validated against gold-standard methods, offering low CV’s and excellent precision giving you the confidence that you are sending out the correct patient results.
Internal Quality Control
As one of the largest manufacturers of true third party quality control solutions, Randox produce high quality materials that can help streamline laboratory procedures whilst saving time and money. With over 390 parameters available in our Acusera Internal Quality Control range, choice and flexibility is guaranteed. You can rely on Randox to deliver trustworthy results time and time again.
External Quality Assessment
Randox International Quality Assessment Scheme (RIQAS) is the world’s largest external quality assessment (EQA) scheme. Currently offering 33 programmes, RIQAS has more than 45,000 laboratory participants in over 130 countries. Delivering a comprehensive yet cost effective EQA solution, RIQAS will help meet regulatory requirements and increase confidence in test system accuracy.
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Extensive Dedicated Test Menu
Extensive test menu allows for revenue generation & business growth via more on-site testing which will also minimise time spent waiting for external results to return. The most extensive test menu on the market enables breadth of diagnosis and provides a competitive market edge resulting in increased profits and business growth.
Low Sample Volume
The RX series is capable of utilising small sample volumes, ranging from 0.5 μl (RX modena) to 5μl (RX misano), thus catering for smaller animals where samples can be hard to obtain.
Flexibility & Versatility
Ability to personalise parameter settings for a wide range of animal species increases lab efficiency. Custom build test menus and create favourites to enable personalised panels, such as diabetes and renal function, or species-specific panels such as equine and companion animals.
The RX Series – The complete solution to your veterinary testing needs!
Randox is an international healthcare diagnostics company with 40 years’ experience as a supplier to the veterinary market. Our extensive product portfolio includes our state of the art RX series of clinical chemistry analysers specifically designed to accurately diagnose and effectively monitor the general health and well-being of a diverse range of animals, including companion animals, livestock, exotic species and birds. In addition, the wide measuring ranges of our assays ensure suitability across a vast range of species. Our RX range allows for accurate diagnosis of veterinary patients with on-site testing.
RX series Dedicated Veterinary Test Menu
| Albumin | Cholinesterase (Butyryl) | Iron (UIBC) | Sodium |
| Alkaline Phosphatase | CK-NAC | Lactate | Total Protein |
| ALT (GPT) | CO2 Total | Lactate Dehydrogenase | Triglycerides |
| Aldolase | Copper | LDL | Urea |
| Ammonia | Creatinine | Lipase | Uric Acid |
| Amylase | Canine CRP | Magnesium | Urinary Protein |
| AST (GOT) | CRP | NEFA (Non-esterified fatty acids) | Zinc |
| Bile Acids | Fructosamine | Phosphorus (Inorganic) | |
| Bilirubin | Gamma - GT | Potassium | |
| Calcium | GLDH | Ranbut (Hydroxybutyrate) | |
| Chloride | Glucose | Ransel (Glutathione peroxidase) | |
| Cholesterol | Glycerol | Ransod (Superoxide dismutase) |
| Alanine Aminotransferase (ALT) | Calcium | D-3-Hydroxybutyrate (Ranbut) | Phosphorus (Inorganic) |
| Albumin | Chloride | Gamma GT | Potassium |
| Aldolase | Cholesterol (HDL) | GLDH | Sodium |
| Ammonia | Cholesterol (LDL) | Glucose | Superoxide Dismutase (Ransod) |
| Amylase | Cholesterol (Total) | Glutathione Peroxidase (Ransel) | Total Protein |
| Aspartate Aminotransferase (AST) | Cholinesterase (Butyryl) | Iron | Triglycerides |
| Bile Acids (4th Gen) | CK-NAC | Lactate | Urea |
| Bile Acids (5th Gen) | CO2 Total | Lipase | Uric Acid |
| Bilirubin (Direct) | Copper | Magnesium | Urinary Protein |
| Bilirubin (Total) | Creatinine | Non-Esterified Fatty Acids (NEFA) | Zinc |
Product availability may vary from country to country. Some product may be for Research use Only. For more information on product application and availability, please contact your local Randox Representative.
RX series Clinical Chemistry Analysers
Superior Performance & Unique Diagnostic Veterinary Reagents
CRP (C-Reactive Protein) is an acute phase protein produced by the liver in response to tissue injury, infection, or other inflammation. In animals, serum levels increase within 4-6 hours of such events, making CRP a much earlier indicator than other acute phase reactants.
Canine CRP is used when inflammation is suspected and allows the extent of inflammation to be determined. Used in conjunction with physical examination of signs and symptoms. It can be used to determine acute inflammatory conditions and to detect a relapse of an immune mediated disease or flare-up of a chronic inflammatory disease.
Bile acids are compounds that are made in the liver and stored in the gall bladder. Bile acids help with digestion of foods, particularly fat. Bile acids are measured to determine liver function and performance; elevated levels of bile acids in the blood are a result of ineffective reabsorption by the liver after digestion, and as such indicate that the liver cells are not functioning well. Randox Bile Acids test allows for liver function issues to be detected quickly, allowing early treatment and enabling the liver to regenerate before irreversible damage occurs.
D-3 Hydroxybutyrate (Ranbut) is a major ketone body in the blood produced when fatty acids in the liver are metabolised for energy. Elevated levels of ketones are referred to as ketosis, and occur when insufficient energy intake results in negative energy balance; ketosis can be toxic and damaging to the kidneys and liver. Many animals suffer an increased risk of ketosis as a result of high energy demands during lactation, pregnancy and birthing.
A major complication associated with ketosis is pregnancy toxemia in ewes or twin lamb disease, a metabolic disorder caused by insufficient nutrients and severe energy shortage.
Glutathione Peroxidase is an antioxidant enzyme that helps protect the body from free radicals. It contains selenium, an important trace element that is essential for enabling selenium-containing proteins, such as glutathione peroxidase, to function correctly.
The Randox Ransel test is used to measure glutathione peroxidase activity to determine functional selenium deficiency; it is considered more accurate than measuring selenium levels directly as low selenium concentration does not necessarily mean an animal is selenium deficient.
Total Antioxidant Status (TAS) is the assessment of the overall antioxidant function in the body. This is determined with the measurement of the total amount of antioxidants circulating the body. Different forms of antioxidants include those which inhibit the formation of free radicals, those which destroy free radicals, and those which repair the cells damaged as a result of free radical attack; a reduction in either of these components can compromise the body’s total antioxidant capacity.
Assessing an animals total antioxidant status is crucial as a reduction in total antioxidant status inhibits defence.
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References
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RX series Niche Test menu
The RX series range of clinical chemistry analyser offers a wide range of speciality tests which opens the opportunity for laboratories to expand their testing services to patients and clinicians. Many of these tests previously would only be possible via the traditional ELISA method but the RX series range of clinical chemistry analysers allow for automation on these tests e.g. adiponectin, this reduces the chances of human error and compromising of clinical results. Some of these tests give us a greater depth of knowledge of illnesses and can mean earlier diagnosis so the correct measures can be taken to treat the illness earlier and increase the chance of recovery. To find out more about the RX series range click here.
Niche Test Menu
| Adiponectin | TxBCardio | Apolipoprotein C-II |
| Lipoprotein (A) | HDL2/3 Cholesterol | Apolipoprotein C-III |
| H-FABP (Heart-Type Fatty Acid Binding Protein) | Homocysteine | Apolipoprotein E |
| Sldl (small-dense LDL Cholesterol) |
| Fructosamine | Non-Esterified Fatty Acids – NEFA | D-3-Hydroxybutyrate (Ranbut) |
| Cystatin C | Liquid Enzymatic Creatinine | Microalbumin |
| Total Antioxidant Status – TAS | Glutathione Reductase | Superoxide Dismutase (Randox Ransod) |
| Aldolase | Glucose-6-Phosphate Dehydrogenase – G-6-PDH | Copper |
| Vanadate Oxidation Bilirubin | Immunoglobulin E – IgE | Zinc |
| 5th Generation Bile Acids |
RX monaco Test Menu
The RX monaco offers high quality routine and specialised testing through the most comprehensive dedicated test menu covering clinical, veterinary, diabetes, lipids and research assays. The low throughput of the RX monaco provides small to mid-volume laboratories with cost effective analysis and high quality testing.
Please see below for the complete RX monaco test menu.
Test Menu
Autoimmune
| Complement Component 3 | CRP High Sensitivity | IgE | IgM |
| Complement Component 4 | IgA | IgG | Rheumatoid Factor |
| CRP Full Range (0.3-160mg/l) |
Basic Metabolic Profile
| Calcium | Creatinine Enzymatic | Glucose | Sodium |
| CO2 Total | Creatinine (Jaffe) | Potassium | Urea |
| Chloride |
Bone Profile
| Alkaline Phosphatase | Calcium | Phosphorus | Total Protein |
Cardiac
| Cholesterol | CRP Full Range (0.3-160mg/l) | Direct LDL Cholesterol | sLDL |
| CK-MB | CRP High Sensitivity | Homocysteine | Triglycerides |
| CK-NAC | Direct HDL Cholesterol | Lipoprotein (a) |
Comprehensive Metabolic Profile
| Albumin | Direct Bilirubin | Creatinine Enzymatic | Sodium |
| Alkaline Phosphatase | Calcium | Creatinine (Jaffe) | Total Bilirubin |
| ALT | Chloride | Glucose | Total Protein |
| AST (GOT) | CO2 Total | Potassium | Urea |
Diabetes
| Cholesterol | Direct HDL Cholesterol | HbA1c/Hb | Total Protein |
| Creatinine Enzymatic | Direct LDL Cholesterol | Microalbumin | Triglycerides |
| Creatinine (Jaffe) | Glucose |
Electrolytes
| Calcium | CO2 Total | Potassium (Non-Direct) | Sodium (Non-Direct) |
| Chloride (Nondirect) | Magnesium |
Haemolytic Anaemia:
| LDH |
Hepatic Function
| Albumin | Cholinesterase | IgA | Iron |
| Alkaline Phosphatase | Complement Component 3 | IgE | LDH |
| ALT | Complement Component 4 | IgG | Total Bilirubin |
| AST (GOT) | Direct Bilirubin | IgM | Total Protein |
| Bile Acids | Gamma GT |
Inflammation & Infection
| Alpha-1Acid Glycoprotein | ASO | CRP | Rheumatoid Factor |
Lipids
| Apolipoprotein A-1 | Apolipoprotein E | Direct LDL Cholesterol | sLDL |
| Apolipoprotein AII | Cholesterol | Lipoprotein (a) | Triglycerides |
| Apolipoprotein B | Direct HDL Cholesterol |
Neonatal Screening
| CRP | CRP Full Range (0.3-160mg/l) | CRP High Sensitivity |
Neurological Disorders (CSF)
| IgA | IgE | IgG | IgM |
Nutritional Status
| Albumin | Iron | Magnesium | TIBC |
| Ferritin | Lipase | Potassium | Transferrin |
Pancreatic Function
| Amylase | Glucose | LDH | Lipase |
Renal Function
| Albumin | Creatinine Enzymatic | LDH | Phosphorus (Inorganic) |
| Ammonia | Creatinine (Jaffe) | Magnesium | Urea |
| Beta-2 Microglobulin | Glucose | Microalbumin | Uric Acid |
| Calcium | HbA1c/Hb | Potassium | |
| Chloride | IgG | Sodium |
Veterinary
| Albumin | Chloride | Glucose | Potassium |
| Alkaline phosphatase | Cholesterol | HDL | Sodium |
| ALT (GPT) | Cholinesterase (Butyryl) | Iron | Total Protein |
| Amylase | CK-NAC | LDL | Triglycerides |
| AST (GOT) | CO2 Total | Lipase | Urea |
| Bilirubin | Creatinine | Magnesium | Uric Acid |
| Calcium | Gamma-GT | Phosphorus (Inorganic) |
Specific Proteins
| Apolipoprotein A-1 | Beta-2 Microglobulin | Ferritin | IgM |
| Apolipoprotein AII | Complement Component 3 | HbA1c/Hb | Lipoprotein (a) |
| Apolipoprotein B | Complement Component 4 | IgA | Microalbumin |
| Apolipoprotein E | CRP Full Range (0.3-160mg/l) | IgE | Rheumatoid Factor |
| ASO | CRP High Sensitivity | IgG | Transferrin |
Antioxidants
| Albumin | Ferritin | Transferrin | Uric Acid |
| Bilirubin | TIBC |
RX misano Test Menu
The RX misano offers high quality routine and specialised testing through the most comprehensive dedicated test menu in the semi-automated market.
The needs of many laboratory types are met with the extensive test menu covering clinical, veterinary, diabetes, lipids and research assays. Please see below for the complete RX misano test menu.
Test Menu
Autoimmune
| IgG | IgA |
Anaemia
| Iron | G6P-DH |
Basic Metabolic Profile
| Calcium | Chloride | Glucose | Sodium |
| CO2 Total | Creatinine | Potassium | Urea |
Cardiac
| Cholesterol | CK-NAC | Direct LDL Cholesterol | |
| CK-MB | Direct HDL Cholesterol | Triglycerides |
Comprehensive Metabolic Profile
| Albumin | Bilirubin (Total/Direct) | Creatinine | Urea |
| Alkaline Phosphatase | Calcium | Glucose | |
| ALT | Chloride | Potassium | |
| AST(GOT) | CO2 Total | Sodium |
Diabetes
| Cholesterol | Direct LDL Cholesterol | NEFA | Urinary Protein |
| Creatinine | Glucose | Ranbut (Hydroxybutyrate) | |
| Cystatin C | Glucose Hexokinase | Total Protein | |
| Direct HDL Cholesterol | Microalbumin | Triglycerides |
Electrolytes
| Calcium | CO2 Total | Potassium | |
| Chloride (Direct/Nondirect) | Magnesium | Sodium |
Inflammation
| Aldolase |
Hepatic Function
| Aldolase | AST (GOT) | Cholinesterase | Total Protein |
| Albumin | Bile Acids | IgA | |
| ALT | Bilirubin (Total/Direct) | IgG |
Lipids
| Apolipoprotein A-I | Cholesterol | Direct LDL Cholesterol | |
| Apolipoprotein B | Direct HDL Cholesterol | Triglycerides |
Nutritional Status
| Albumin | Lipase | Potassium | |
| Iron | Magnesium | Zinc |
Renal Function
| Albumin | Cystatin C | Potassium | Urea |
| Beta-2 Microglobulin | Glucose | Sodium | Uric Acid |
| Calcium | IgG | Phosphorus | |
| Creatinine | Microalbumin | Urinary Protein |
Veterinary
| Albumin | Chloride | Glucose | Ransel (Glutathione peroxidase) |
| Alkaline phosphatase | Cholesterol | Iron | Ransod (Superoxide dismutase) |
| ALT (GPT) | Cholinesterase | Lactate | Sodium |
| Ammonia | CK-NAC | Lipase | Total Protein |
| Amylase | CO2 Total | Magnesium | Urea |
| AST (GOT) | Copper | NEFA (Non-esterified fatty acids) | Uric Acid |
| Bile acids | Creatinine | Phosphorus (Inorganic) | Urinary protein |
| Bilirubin | Gamma-GT | Potassium | |
| Calcium | GLDH | Ranbut (Hydroxybutyrate) |
Antioxidants
| Glutathione Reductase | Ransel (Glutathione Peroxidase) | Ransod (Superoxide Dismutase) |
Food and Wine Testing
| Acetic Acid | Glucose/Fructose | TAS | |
| Ammonia | Malic acid | ||
| Copper | Potassium |
Product availability may vary from country to country. Some product may be for Research use Only. For more information on product application and availability, please contact your local Randox Representative.
British Science Week – Interview with Daniel Melly our design engineer
This week is British Science Week, a week dedicated to inspiring innovation and celebrating science. To mark the occasion the RX series team caught up with Daniel Melly, one of our very talented mechanical design engineers based in Randox Teoranta in Dungloe, Ireland.
Daniel was an integral part of the team involved in the design of our new semi-automated analyser, the RX misano.
We asked Daniel a few questions about why Randox created this analyser, the design process involved in creating such a unique system and what his favourite features are. Check out our interview below.
First of all, why have Randox created the RX misano?
Randox set out in creating the RX misano with the philosophy of supplying the customer with a more modern, reliable, and aesthetically pleasing analyser than those that are currently available on the market. Robust part selection was always at the fore of any design decisions and we feel that we have delivered on all of these requirements.
What makes the RX misano unique?
From your first sight of the misano, it strikes you with its non-conventional cover design, its glossy touch screen, and its compact footprint. Weighing approximately 6.0kg, it can be easily moved from location to location. A really user-friendly interface that was uniquely designed by our embedded systems engineers allows the customer to interact with the analyser with ease while still dwarfing any competitors with its creative functionality.
Are there any advantages to the RX misano test menu?
With a vast test menu available as standard on the analyser, creation of unique tests are easily saved within the analyser for the customer to repeatedly use. The customer has lots of parameter selections for all attributes needed to build a test.
In your opinion, is the analyser easily maintained?
The analyser is very easily maintained. It is desired that the customer perform simple weekly washes of the fluids to ensure no debris build up from samples, and built in software timers advise the customer when the “halogen bulb” and “pump tubing” should be replaced. These are the only two parts within the machine that the customer will be required to come into contact with for maintenance purposes.
From an engineer’s perspective what do you find most interesting about the RX misano build?
Being a mechanical engineer, I find the unique detection design the most interesting part of the analyser. With almost a total static design implemented, this enabled the engineers to focus on the selection of reliable and compact components that would be subjected to a vast variety of environments. The collaboration of all disciplines within the engineering department here in Dungloe was very efficient throughout the project, and this lead to a quick turn-around from the design phase through to transfer to manufacturing.
What is your favourite feature and how would this benefit our customers?
The trendy touch screen that creates a comfortable interaction for the customer is a great feature in my opinion.
Why would you pick the RX misano over competitors?
As described above, if you want the most up to date technology, a design that prides itself on its reliability and an analyser that you can tuck under your arm and carry from place to place, then the misano is the perfect selection for any customer requiring semi-automatic capabilities.
Finally, can you outline the manufacturing process? How does this benefit our customers?
The manufacturing of the analyser is done in a safe methodical way which eliminates the occurrence of errors in the build. Most component design is done with a “poka yoke” characteristic applied, and this aids the trained Manufacturing staff to build the desired quality of analyser that will be ultimately delivered to a happy customer.
Thank you Daniel for taking the time to chat with us today, we really appreciate our dedicated and hard-working team committed to producing the highest quality products to continue saving lives globally.
The RX series is a versatile range of clinical chemistry analysers designed by Randox, combining robust hardware and intuitive software with the world leading RX series test menu, the RX series guarantees real cost savings through consolidation of routine and specialised tests onto a single platform.
For more information on the RX misano, visit http://www.randox.com/rx-misano/ or contact us at theRXseries@randox.com
RX series
About The RX series Clinical Chemistry Analysers
Patient care is the primary focus of clinical chemistry testing and Randox has developed the RX series of clinical chemistry analysers for high quality semi-automated and fully automated testing. The RX series continues to revolutionise a variety of laboratory types including:
– Clinical Laboratories
– Hospital Laboratories
– University & Educational Institutes
– Research Laboratories
– Veterinary Laboratories
– Food & Wine Laboratories
Did you know?
The RX series have analyser
placements in over 120
countries worldwide
The RX series combines robust hardware and intuitive software with the world leading RX series test menu, including routine chemistries, specific proteins, lipids, therapeutic drugs, drugs of abuse, antioxidants and diabetes testing. Renowned for quality and reliability, the RX series has one of the most extensive dedicated clinical chemistry test menus on the market guaranteeing real cost savings through consolidation of routine and specialised tests onto a single platform. This extensive dedicated test menu of high quality reagents guarantees excellence in patient care ensuring unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.
Choose from the RX misano, RX monaco, RX daytona+, RX imola and RX modena to start your journey with the RX series today.
Click on the analysers below for more information
Why choose the RX series?
The RX series Extensive Dedicated Test Menu
Autoimmune
| Complement Component 3 | CRP Full Range (0.3-160mg/l) | IgE | Rheumatoid Factor |
| Complement Component 4 | CRP High Sensitivity | IgG | |
| CRP | IgA | IgM |
Basic Metabolic Profile
| Calcium | Creatinine Enzymatic | Potassium | |
| CO2 Total | Creatinine (Jaffe) | Sodium | |
| Chloride | Glucose | Urea |
Bone Profile
| Alkaline Phosphatase | Calcium | Phosphorus | Total Protein |
Cardiac
| Cholesterol | CRP Full Range(0.3-160mg/l) | Direct LDL Cholesterol | sLDL |
| CK-MB | CRP High Sensitivity | Heart-Type Fatty Acid Binding Protein (H-FABP) | Triglycerides |
| CK-NAC | Digoxin | Lipoprotein(a) | TxB Cardio |
| CRP | Direct HDL Cholesterol | Myoglobin |
Comprehensive Metabolic Profile
| Albumin | Calcium | Glucose | Total Protein |
| Alkaline Phosphatase | Chloride | Lactate | Urea |
| ALT | CO2 Total | Potassium | |
| AST (GOT) | Creatinine Enzymatic | Sodium | |
| Direct Bilirubin | Creatinine (Jaffe) | Total Bilirubin |
Diabetes
| Cholesterol | Direct HDL Cholesterol | Glycerol | Ranbut (Hydroxybutyrate) |
| Creatinine Enzymatic | Direct LDL Cholesterol | HbA1c/Hb | Total Protein |
| Creatinine (Jaffe) | Fructosamine | Microalbumin | Triglycerides |
| Cystatin C | Glucose | NEFA (Non-Esterified Fatty Acids) | Urinary Protein |
Electrolytes
| Calcium | Lithium | Sodium (Direct/Nondirect) | |
| Chloride (Direct/Nondirect) | Magnesium | ||
| CO2 Total | Potassium (Direct/Nondirect) |
Haemolytic Anaemia
| G6P-DH | Haptoglobin | LDH |
Hepatic Function
| Albumin | Complement Component 3 | IgG | Transthyretin (Prealbumin) |
| Aldolase | Complement Component 4 | IgM | |
| Alkaline Phosphatase | Direct Bilirubin | Iron (UIBC) | |
| Alpha-I Antitrypsin | Gamma GT | LAP | |
| ALT | GLDH | LDH | |
| Ammonia | Glycerol | Total Bilirubin | |
| AST (GOT) | Haptoglobin | Total Protein | |
| Cholinesterase | IgA | Transferrin |
Inflammation and Infection
| Alpha-I Acid Glycoprotein | ASO | CRP | Lactate |
| Rheumatoid Factor |
Lipids
| Apolipoprotein A-I | Apolipoprotein CII | Cholesterol | Lipoprotein(a) |
| Apolipoprotein AII | Apolipoprotein CIII | Direct HDL Cholesterol | sLDL |
| Apolipoprotein B | Apolipoprotein E | Direct LDL Cholesterol | Triglycerides |
Neonatal Screening
| Alpha-I Antitrypsin | CRP Full Range (0.3-160mg/l) | IgE |
| CRP | CRP High Sensitivity | Transthyretin (Prealbumin) |
Neurological Disorders (CSF)
| IgA | IgG | IgM |
Nutritional Status
| Albumin | Iron | Magnesium | Transferrin |
| Copper | Iron (UIBC) | Potassium | Transthyretin (Prealbumin) |
| Ferritin | Lipase | TIBC | Zinc |
Pancreatic Function
| Amylase | LDH | Pancreatic Amylase | |
| Glucose | Lipase |
Renal Function
| Albumin | Creatinine Enzymatic | IgG | Phosphorus (Inorganic) |
| Ammonia | Creatinine (Jaffe) | LDH | Urinary Protein |
| Beta-2 Microglobulin | Cystatin C | Magnesium | Urea |
| Calcium | Glucose | Potassium | Uric Acid |
| Chloride | HbA1c/Hb | Sodium |
Veterinary
| Albumin | Cholesterol | Glycerol | Ranbut (Hydroxybutyrate) |
| Alkaline phosphatase | Cholinesterase (Butyryl) | HDL | Ransel (Glutathione peroxidase) |
| ALT (GPT) | CK-NAC | Iron (UIBC) | Ransod (Superoxide dismutase) |
| Aldolase | CO2 Total | Lactate | Sodium |
| Ammonia | Copper | Lactate dehydrogenase | Therapeutic drugs |
| Amylase | Creatinine | LDL | Total Protein |
| AST (GOT) | CRP | Lipase | Triglycerides |
| Bile acids | Fructosamine | Magnesium | Urea |
| Bilirubin | Gamma-GT | NEFA (Non-esterified fatty acids) | Uric Acid |
| Calcium | GLDH | Phosphorus (Inorganic) | Urinary protein |
| Chloride | Glucose | Potassium | Zinc |
Therapeutic Drugs:
| Carbamazepine | Lithium | Phenytoin | Valproic Acid |
| Digoxin | Acetaminophen | Salicylate | |
| Gentamicin | Phenobarbitol | Theophyline |
Drugs of Abuse
| Amphetamines | Cannabinoids | Ecstasy | Opiates | |
| Barbiturates | Cocaine metabolite | Ethanol | ||
| Benzodiazepines | EDDP | Methadone |
Specific Proteins
| Alpha-I Antitrypsin | ASO | Cystatin C | IgM |
| Alpha-I Acid Glycoprotein | Beta-2 Microglobulin | Ferritin | Lipoprotein (a) |
| Apolipoprotein A-I | Ceruloplasmin | Fructosamine | Microalbumin |
| Apolipoprotein AII | Complement Component 3 | Haptoglobin | Myoglobin |
| Apolipoprotein B | Complement Component 4 | HbA1c/Hb | Rheumatoid Factor |
| Apolipoprotein CII | CRP | IgA | Transthyretin (Prealbumin) |
| Apolipoprotein CIII | CRP Full Range (0.3-160mg/l) | IgE | Transferrin |
| Apolipoprotein E | CRP High Sensitivity | IgG |
Antioxidants
| Albumin | Glutathione Reductase | TIBC | Uric Acid | |
| Bilirubin | Ransel (Glutathione Peroxidase) | Total Antioxidant Status | ||
| Ferritin | Ransod (Superoxide Dismutase) | Transferrin |
Biotechnology
| Glutamate | Glutamine |
Food and Wine Testing
| Acetic Acid | Copper | Glycerol | Malic Acid | |
| Ammonia | Glucose | Iron | Potassium | |
| Calcium | Glucose/Fructose | L-Lactic Acid | Total Antioxidant Status |
Speciality
| Acid phosphatase |
