30th June 2016 - Randox Laboratories

Age is associated with increases in body weight, body fat, abdominal fat, deterioration of muscles, and arthritis. However, everything in the body happens at the cellular level. Outward signs of aging that you may see, such as wrinkles and grey hair, are only symptoms of what is happening on a microscopic scale.

A study carried out by Raul A Martins, using the RX imola, outlined an experiment, investigating how we can affect our own inner-biological make-up, on a much deeper scale than muscle build-up, through exercise and activity:

“To investigate the training effect of sixteen weeks of moderate intensity, progressive aerobic and strength-based training on metabolic health of old women and men. Sixty three sedentary individuals were randomly assigned to control or exercising groups. The training group was separated to aerobic or strength-based. Training took place 3 times a week. Subjects agreed not to change their diet or lifestyle over the experimental period. Exercising group attained after treatment significant differences on body weight, waist circumference, body mass index, diastolic blood pressure, triglycerides, total cholesterol, HDL cholesterol, LDL-cholesterol, total cholesterol/HDL-cholesterol relationship, high sensitivity C-reaction protein and 6 minute walk distance. The control group only had significant differences on waist circumference” wrote R.A. Martins and colleagues, university of Coimbra.”

As shown in the experiment, exercising does not only affect our muscle mass and body fat index. It does, in fact, affect us on a cellular level.

Before outward aging symptoms are expressed, your cells, your DNA, and everything that makes up you is reacting to your lifestyle and responding appropriately. A particularly lifestyle-sensitive part of your DNA associated with aging are telomeres.

Telomeres are caps at the ends of DNA strands, made up of a combination of DNA and protein. They protect the ends of the chromosome and keep them stable. Telomeres, however, are incredibly sensitive and have a tendency to become damaged and unravel, prompting a process called “telomere shortening”. Telomeres are associated with the changing nature of our bodies, and therefore, are classed as important aging biomarkers – with their length indicating lifespan. Each time our cells divide, our telomeres shorten. After many dozens of years of cell division, these biomarkers have reached a point where they can longer become any shorter. At this point, cell division discontinues and this is where aging will occur, as cells begin to die faster than they are created. Our body begins to break down. Effects such as hair falling out and skin sagging, are all symptoms of telomere damage or shortening. Telomere shortening has not only been associated with aging, but also age-related diseases such as Parkinson’s disease, Alzheimers, cardiovascular disease, Diabetes, and some forms of cancer.

There is good news, Martins noted in his experiment that exercise appears to keep telomeres from unravelling, shortening and becoming damaged, and therefore, can be classed as a natural anti-aging activity.

Through examining white blood cells, scientists can monitor telomere shortening (and damaging) whilst monitoring exercise and lifestyle of subjects. Another group of scientists in Germany conducted a similar experiment, gathering women and men of different ages to examine their lifespans relative to exercising, they noted:

The sedentary older subjects had telomeres that were on average 40 percent shorter than in the sedentary young subjects, suggesting that the older subjects’ cells were, like them, aging. The runners, on the other hand, had remarkably youthful telomeres, a bit shorter than those in the young runners, but only by about 10 percent. In general, telomere loss was reduced by approximately 75 percent in the aging runners. Or, to put it more succinctly, exercise, Dr. Werner says, ‘‘at the molecular level has an anti-aging effect.’’

(Gretchen Reynolds, 2010)

So, to put a number on it, studies show, exercise can reduce the aging process by up to a whopping 75%.

As well as it’s anti-aging properties, there are a surplus of other benefits of exercising, such as increased release of endorphins and relieving of muscular pain. Currently, there’s a good deal of research being conducted into potential drug based approaches for telomere shortening, yet these drugs are still years away. So, for now, exercise and healthy eating is the only known way to stave off aging… As if we needed another healthy reason to get active!

Randox’s Public Relations Executive, Amy McIlwaine, tells us about her time in New York State, working in Camp Wakonda (Homes for the Homeless)

We’re celebrating the bright and vibrant lives of Randox employees, and the way in which these inspiring individuals have helped to make Randox as great as it is today. Stay up to date with the #WeAreRandox hashtag on Twitter and Instagram to hear more stories.

We were discussing our most inspiring moments with Amy McIlwaine, Public Relations Executive of Randox Laboratories, this week. She told us a story of her time volunteering with children in New York State that we knew we had to share! We hope her story inspires you as much as it did us:
Here is Amy’s story:

“During my years at school and at University I worked as a part-time lifeguard in a local pool. I’ve always been quite ambitious, so, when the time came to graduate and I decided to do some overseas work, I applied to be Waterfront Director at a camp in New York State, called Camp Wakonda.

When I say the words ‘Summer camp’ to people they usually picture expensive facilities with music suites, maybe some horse stables and jet-skis, with a love-able rogue Joe Jonas lookalike thrown in for good measure, but Camp Wakonda wasn’t quite like that!

Camp Wakonda is a Summer camp that is run by the Homes for the Homeless organisation, and accepts children between 6 and 10 years old who are homeless and living in New York shelters.

The camp has limited resources, cabins with no electricity, and various (sometimes) friendly camp companions such as bears, chipmunks and rattlesnakes (we were in the middle of the woods). Children came to camp with very few belongings – sometimes even without a decent pair of shoes. But in spite of all that, it’s one of my favourite places on this earth. Being free from the stresses of everyday life (mind you, working with 90 children at a time brings a different kind of stress!) is wonderfully liberating and living in the middle of nature brings a certain serenity.

Although we had such limited resources, we had the time of our lives! You learn to be really creative – we had themed days throughout the summer like a Harry Potter banquet, a ‘Fairytales of Wakonda’ pantomime, and even Christmas on the 25^th July! That one was probably my favourite – some of the children had never had a real Christmas before. I’m happy to admit that I welled up when I saw how incredibly excited they were at receiving just one small gift.”

Smiling from ear-to-ear, Amy went on to highlight the importance of the camp she worked in, in offering homeless children from New York the opportunity to just enjoy being kids, and how this inspired her:

“The spirit of the children, and the counsellors, at Camp Wakonda is something that I had not come across before, and have not come across since. For children who have had such a difficult upbringing, they came to camp with the biggest smiles on their faces, and the smallest things like three hot meals a day meant the world to them. It was great to see them free from the stresses of their unfortunate circumstances. For me, as their swimming teacher, nothing made me smile more than when a child came running up to me shouting ‘Miss Amy, I learned how to float today!’ or when a camper who had been so scared of the water finally got in and had a beaming smile from ear-to-ear when I handed them a swimming certificate. Many of the children had never left the city, and so had never experienced some of the things that we take for granted – like being able to see the stars in the sky at night.

I lived and worked in Wakonda for three months during 2014, and went back again in 2015, as Unit Leader of the older girl’s unit. I was responsible for counselor training, and the welfare of both the girl campers and the female counselors. When you’re practically working 24/7 for three months, the children become your entire life – everything that you do is with their needs in mind. Because of this, the children are so grateful of the time and attention that the counselors give them.

The work that Homes for the Homeless does for those kids is amazing, it really makes a difference to their lives, and I’m so glad that I have been part of it.”

Find out more about Camp Wakonda in this NY 1 News coverage video, here.

Randox wouldn’t be the innovative and caring healthcare company it is today without the hard work of young people with fresh perspectives and world experience like Amy – so we’re delighted that she has brought her enthusiasm to our team! We hope her story inspired you to take part in your community through volunteering. For us, we never stop. We’re helping to improve healthcare and diagnostics through consistent hard work, because for us, this means saving lives.

If you’re looking for a career in Business, Science or Engineering, let Randox be the next step in your adventure!

Follow us on Facebook, Twitter or Instagram or stay up-to-date with the hashtag #WeAreRandox. Visit our website to view our careers opportunities at Randox Laboratories.