Randox Alzheimer’s Array on the Evidence Investigator
Randox Alzheimer’s Array on the Evidence Investigator
Alzheimer’s disease
Alzheimer’s disease is the most common cause of dementia. It is defined as an irreversible, progressive brain disorder, in which parts of the brain are damaged over time. As this happens symptoms develop, but also get worse.
Dr. Alois Alzheimer discovered that in Alzheimer’s disease the connections between the cells and brain tissue are lost because proteins build up and form abnormal structures called “plaques” and “tangles”. 1 A healthy brain contains important chemicals which send signals between the cells, however, those who suffer with Alzheimer’s have less “chemical messengers.” Therefore, the signals don’t get passed on. 1
Risk factors
Age is the biggest risk factor. Alzheimer’s disease is more common amongst older adults. In the UK there are over 40,000 people under the age of 65 who suffer with some form of dementia. 2 Studies also state that women over the age of 65 are twice as likely to develop Alzheimer’s disease than men – although there is no clear evidence as to why.
There are two different types of Alzheimer’s. The early on-set variant of the condition is very uncommon but strikes people younger than 65. Often people with early-onset Alzheimer’s develop symptoms in their 40s or 50s. Whereas, late-onset Alzheimers is more common and affects people age 65 and older. 2
Symptoms
The disease slowly destroys memory and thinking skills. The earliest symptoms are memory lapses where they may struggle to remember recent events or learn new information, or even forget important items for day-to-day life for example, their keys, glasses or mobile phone. Memory loss due to the disease can increasingly interfere with their life as often the ability to carry out simple tasks can become a struggle. As a result, the person suffering can become anxious, irritable and can even be depressed.
In the later stages of Alzheimer’s, the symptoms become more severe. The individual will become less aware of what’s happening around them. They may have difficulties eating, walking and will require additional help and support with their daily activities from their loved ones or from a carer.
Unfortunately, there is no cure for Alzheimer’s Disease, although, there is treatment that can help manage the symptoms.
The Randox Apolipoprotein E4 Array
Randox offers The Apolipoprotein E4 (ApoE4) Array.
The Apolipoprotein E4 (ApoE4) Array is a research use-only product developed for the Evidence Investigator, which is a semi-automated benchtop immunoassay analyser which can process up to 2376 test per hour as well as up to 44 analytes screened per biochip.
The ApoE4 Array measures both total ApoE protein levels and ApoE4 protein levels directly from plasma samples and by using a ratio it can classify patients as negative or positive for ApoE4. In turn we can then assess their risk for the development of Alzheimer’s disease.
For further information about the Randox Alzheimer’s Array or our Evidence Investigator, please email info@randoxbiosciences.com
- https://www.alzheimers.org.uk/about-dementia/types-dementia/alzheimers-disease-symptoms
- https://www.nia.nih.gov/health/what-alzheimers-disease
Randox Toxicology: Global drug use trends going into 2019
In the turn of the new year, we look at the current trends in drug abuse in 3 key continents and what their key 2018 figures say about drug use in their countries.
The Americas
New psychoactive substances have been an emerging drug market in the Americas, with a total of 130 different new psychoactive substances being reported in seven South American countries in August 2017. This was more than a 50% increase within the year, as over 60 different substances had been reported in 2016 alone, according to the OAS and CICAD Report on Drug Use in The Americas 2019. Latin America have experienced a surge in LSD, synthetic cannabinoid, plant substance and ketamine use among the general population as well.
Meanwhile, opioids and prescription opioids have been a major cause for concern in the Americas, with opioid analgesics involved in more overdose fatalities than any type of illicit drug, exceeding cocaine and heroin-related fatalities in Canada and USA combined. Users are increasingly turning to street opioids as well, which are often mixed with heroin and other drugs. The major challenge noted in the same report is the complexity of the appearance of NPS and the counterfeit substances it contains.
Europe
Cannabis has had the highest use among males, with most cases being regular patterns of use. Around 1% of European adults are considered daily users according to the European Drug Report 2018. Regarding opioids, heroin is the most common drug of abuse in this category, and prevalence of high risk opioid use among adults is estimated to be at 0.4% of the EU population.
Synthetic opioids, such as fentanyl, are growing in use in Europe. In 2016, over 18 European countries reported more than 10% of all opioid clients entering specialised services suffering from opioid addiction other than heroin.
Asia
Opioids present the largest drug problem in Asia, having the highest proportion of causes of drug users going to treatment centres, followed by amphetamine-type stimulants and cannabis. Production of drug substances in Asia have been significant in the last 3 years, with cocaine and opium production hitting record highs. Methamphetamine is also an emerging threat to Asia, with production of the synthetic drug overtaking heroin.
Our testing solution
Randox Toxicology are first to market when it comes to testing for the latest drugs of abuse and new psychoactive substances in the market. Our revolutionary Biochip Array Technology provides state-of-the-art drug detection, utilizing simultaneous drug detection from a single sample across multiple matrices.
Our ELISA kits provide a comprehensive test menu, covering a broad range of drugs of abuse, stimulants, analgesics and sedatives. Randox Toxicology develop the highest quality 96-well microtitre plates available to the market, with results providing excellent correlation with confirmatory methods.
To find out more email us at: info@randoxtoxicology.com or visit our website: www.randoxtoxicology.com
Getting tested for Genetic Haemochromatosis
“When I reached my mid-fifties, a suffered a lot of fatigue and general body weakness. I worried that I had inherited genetic hemochromatosis from my mum. Randox Health gave me peace of mind that my symptoms were not down to an inherited condition, but dietary issues which were easily corrected.”
Hereditary haemochromatosis, which was discussed this morning on BBC Radio 4, causes your body to absorb too much iron from the food you eat. The BBC News report today said that Exeter University has found the condition could affect up to 20 times more people than earlier figures suggested.
It was believed to seriously affect about one in 100 carriers. But the new research has suggested the true level could be closer to one in 10 among female carriers, and one in five for men. This would make the genetic condition the UK’s most common genetic disorder.
Lead researcher Prof David Melzer commented;
“We’ve shown that hereditary haemochromatosis is actually a much more common and stealth disease, including in older people.”
Excess iron within those suffering from genetic heamochromatosis is stored in the organs, especially the liver, heart and pancreas. Too much iron can lead to life-threatening conditions, such as liver disease, heart problems and diabetes.
Prof Melzer said haemochromatosis was easy to treat if caught early enough, but was “difficult to spot,” with the main reason being that diagnosis is quite often made at a stage when much of the damage from the condition has already been done.
It is clear therefore that early diagnosis is key in successful management of genetic haemochromatosis.
If you are found to have excess levels of iron as a result of genetic haemochromatosis, treatment is relatively simple and consists of venesection (bloodletting.) The body makes more blood to replace that taken, and therefore uses up the excess stored iron.
Randox Health offers a specialised test for detecting genetic hemochromatosis so if you’re worried about developing symptoms, or already think you have developed symptoms – including fatigue, joint disease, skin problems, and sexual health issues – get in touch today.
Early diagnosis and treatment of GH can seriously improve the outcome for individuals with the condition, by preventing any further organ damage. Randox Health not only offers a test to screen for the genetic mutations most commonly associated with GH, we can also check at the same time for damage to other parts of the body as a result of high iron levels (e.g. diabetes, liver damage and heart damage).
Furthermore, if you do have GH, your close family members should also be screened for the condition.
Get in touch today to book your appointment. Phone 0800 2545 130 or email info@randoxhealth.com
We Are Randox | Armagh GAA forward Stefan Campbell
One of our favourite things about our We Are Randox series of staff interviews is the opportunity we are given to find out about the unique and interesting talents of our colleagues.
From creative bakers to melodious musicians, motivated Girl Guide leaders to athletic sportspeople, many of our staff are just as busy outside of the office as they are in it.
Take Tender Coordinator Stefan Campbell for instance. By day Stefan spends time identifying potential business for the company – conducting local and global searches, collating technical specifications and compiling financial information – but in the evenings and weekends he’s impressively one of the forwards for the Armagh Senior Footballers, a Gaelic Football team that competes at an all-Ireland level.
We caught up with Stefan to find out about his intense training regime, his goals for the future of his GAA career, and of course his advice for the newly-formed Randox GAA team!
Here’s Stefan’s story.
I suppose Gaelic Football has always run through the different generations of my family so it was only natural that I began playing at a young age. My brother John played for our local club Clan Na Gael, so after having played for St. Pauls Lurgan, I then moved to Clan Na Gael where he played. I’ve now been a member there for 16 years.
Our County Club, Armagh, then won their first All-Ireland Championship in 2002, with a team that included two players from Clan Na Gael, and so I was inspired to try out for my county myself. The rest as they say, is history.
I’m currently in my 7th season with the Armagh Senior Footballers, after having played for the U18 and U21 squads. My position is usually full forward, alongside two other team mates, however I do often rotate amongst the total line-up of 6 forwards.
Obviously being a forward I am expected to score in each game, and to give you an idea of figures I have had two games in the last week in which I scored 8 points against Antrim and 3 points against Monaghan. I therefore have to make sure to refine my skills in terms of scoring, passing, and timing of the tackle, but there is also quite a lot of emphasis on just simply working hard and putting in the effort to train, as it is an incredibly physical game. Typically, a county team trains 4 nights a week with 2 sessions being in the gym and 2 on the field, at the Callanbridge facility in Armagh.
I’ve played in the opening 3 games of The Dr McKenna Cup (a Gaelic Football competition between counties and universities in Ulster) thus far, and need to make sure I keep up my training so that I remain in the team for the upcoming matches. There is a lot of pressure coming from other very talented squad members, looking for their opportunity to impress, so I have to be on top form.
In the short-term, we have The Dr McKenna Cup Final against Tyrone this Saturday (in which I’m obviously hoping for a win!) and in the longer term I’m really hoping I can win an Armagh Championship with Clan Na Gael. I would also love to secure an Ulster Championship win with Armagh, which is a title I’m still searching for, even though I won the Railway Cup in 2017 playing for Ulster.
The Railway Cup is an annual tournament steeped in history, as it dates back as far as 1927. There is such a large pool of players to choose from when forming an Ulster team, so I know my family was very proud when I was selected, and even more so when we went on to defeat Connaught in the final. I loved the opportunity to play alongside teammates I’m usually competing against.
Another highlight of my GAA career was when I played Gaelic Football in New York, over the course of two summers. Although GAA is an Irish organisation, Gaelic Football is played all over the world in countries such as Dubai, Hong Kong, Australia and the USA, albeit at a lower level than it is played back home. Local players are poached and asked if they would be interested in playing for a particular team in the summer, while they set you up with a job and accommodation. In 2015 I was asked to play for Kerry New York and in 2017 for Westmeath New York, and I found the temptation to spend 3 months abroad, basically free of charge, too good to turn down.
For the record though, GAA is an amateur organisation and therefore as players we don’t get paid to do what we do. Don’t get me wrong, it has its perks, like the unique opportunity to play live on Sky or on the BBC, but ultimately, we play for the love of the sport, while representing our families and communities. It’s this passion that drives me each week to train consistently and improve my skills, even after a day’s work at the Randox office. I do often have long days during which I leave work, go straight to training, and arrive home at about 10.45pm, but it’s something I’m used to and prepare for accordingly. I will say though that it’s extremely difficult to get out of bed on Mondays having played a game the previous day!
As luck will have it, joining Randox means that I now have the opportunity to bring my two careers together, as the company has recently established its own GAA team, which recently competed in the FinTru Ulster Inter-Firms Competition. I don’t see any reason, that with a bit of luck, and the experience we now have from last year, why we can’t get bigger and better and reach this year’s final.
My advice would be to get the squad together as often as our other commitments will allow, to give us more time to polish up our skills, but also, importantly, to become more familiar with our teammates from other departments. I have often found that the most successful teams are not always the most talented, but those with a tighter bond – as they understand their fellow players, can anticipate their game play, and are willing to work that bit harder for one another.
For more We Are Randox stories about our amazing colleagues, make sure to follow us on Facebook, Instagram and Twitter and follow the hashtag #WeAreRandox.
For further information please contact Randox PR by emailing randoxpr@randox.com
Raising awareness of sexual health on National STIQ Day
National STIQ Day
National STIQ day was introduced in 2010 and every year since then the 14th of January has been dedicated to raising awareness for STIQ. The purpose is to emphasize the importance of sexual health and to encourage everyone to get regular health checks.
Sexually Transmissible Infections (STIs) are infections passed from one person to another through unprotected vaginal, oral, or anal sex, or genital contact.
Lack of symptoms
More and more people in the UK are catching STIs and each year the infection rate is rising. According to The World Health Organization (WHO), more than 1 million STIs are acquired every day and the majority of these STIs have no symptoms.1 Therefore you could have an STI and not be aware. 70% of women and 50% of men show no symptoms after contracting Chlamydia which is the most common STI condition in the UK.2
Even though the majority of the time symptoms of STIs aren’t visible, there can be signs of having an STI, including unusual discharge from the vagina, penis or anus, pain when peeing, lumps or skin growth around the genitals, a rash, unusual bleeding, itchiness or blisters around the genitals.3
What to do when you catch an STI
Anyone can catch an STI regardless of what age you are, your sexuality or how many sexual partners you have, as it only takes one sexual encounter to put you at the risk of catching an STI. A shocking fact from Public Health England shows that a case of chlamydia or gonorrhea is diagnosed in a young person every 4 minutes in England, and over 144,000 diagnoses of these sexually transmitted infections are seen in people aged 15 to 24 in 2017. 4
It is extremely important to get routinely tested. The earlier the diagnosis is made and treated the less chance of having long-term effects including infertility.
Randox Biosciences 10-plex STI test
Randox Biosciences would like to take the opportunity to support STIQ day by offering our CE marked 10-plex STI test, a cost-effective solution for accurate STI testing. This test detects the following 10 infections simultaneously from a single patient urine sample.
- Neisseria gonorrhoea (NG)
- Mycoplasma genitalium (MG)
- Ureaplasma urealyticum (UU)
- Chlamydia trachomatis (CT)
- Trichomonas vaginalis (TV)
- Haemophilus ducreyi (HD)
- Mycoplasma hominis (MH)
- Treponema pallidum (TP)
- Herpes simplex virus 1 (HSV-1)
- Herpes simplex virus 2 (HSV-2)
Does your laboratory or clinic carry out STI testing? Our molecular analyser, the Bosch Vivalytic, powered by our award winning Biochip Array Technology, could be the diagnostic solution.
For more information about our STI Arrays or Vivalytic email: info@randoxbiosciences.com
- https://www.who.int/news-room/fact-sheets/detail/sexually-transmitted-infections-(stis)
- http://www.national-awareness-days.com/stiq-day/
- https://www.gov.uk/government/news/an-sti-is-diagnosed-in-a-young-person-every-4-minutes-in-england
- https://www.nhs.uk/conditions/sexually-transmitted-infections-stis/
We Are Randox | Staff Newsletter 2018 Edition
Staff Newsletter 2018 Edition
We are delighted to be able to share with you the bumper 2018 edition of our We Are Randox staff newsletter!
Click here for a range of company and staff news from the past year – including the world’s greatest steeplechase The Randox Health Grand National, Randox Teoranta’s Open Day in Donegal and, of course, our annual Christmas Raffle and Santa Visit– at which we raised an impressive £3,380, taking our fundraising total to £8,846.98 from July to December 2018!
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Meeting Your Drug and Alcohol Testing Needs with RTS
Workplace drug and alcohol testing
At Randox Testing Services, workplace drug and alcohol testing is one part of the services we provide. Our aim is to raise awareness around the dangers of substance misuse and help companies make their workplaces safer. However, our service offering also extends to other sectors.
We provide comprehensive testing for those in the medico-legal market and private individuals. The testing requirements for these markets differ significantly, with unique circumstances that need to be taken into consideration.
Medico-legal testing for drugs and alcohol may be required by various professional bodies involved in child custody cases, care proceedings or child protection cases. In cases regarding divorce and children, a dispute may arise during the process of discussions involving the custody of the child. Drug and alcohol testing may be sought if there has been a substance abuse claim against a parent fighting for custody or visitation.
Drug and alcohol testing is important to ensure child protection from the detrimental effects of parental substance misuse and to ensure they have a quality of life they deserve. In addition, it is also important to enable parents the opportunity to get the help and support they need and begin rehabilitation treatment.
In some cases, customers will require a one-off test as part of a job application, court order or for abstinence monitoring as part of an agreed programme with their employer. These various scenarios highlight the importance that drug and alcohol testing can play on a person’s life.
Our Expertise
At Randox Testing Services we provide drug and alcohol testing services to all professionals within the family law sector and private individuals. Our hair drug testing service utilises fully accredited testing methods and is made more cost effective through the patented testing methods we have developed.
We understand the impact a positive result can have on a parent, child, and extended family and ensure results of the highest accuracy. With over 35 years’ experience in the diagnostic industry, we have gained reputation as a trusted provider.
Randox Testing Services
We can supply individuals with a drug and alcohol service without the need to enter into any contracts. This service is available to anyone and can be facilitated by Randox Testing Services from sample collection to laboratory analysis; or with point of care kits to carry out drug and alcohol testing for instant results.
Visit our website today for more information:
Medico-legal Testing: https://www.randoxtestingservices.com/medico-legal-testing/
Private Individuals: https://www.randoxtestingservices.com/private-individuals/
Contact Us: https://www.randoxtestingservices.com/contact-us/
Phone: +44 (0) 161 741 2760
Randox Toxicology Highly Sensitive ELISA kits
Enzyme-linked immunosorbent assay, or ELISA, has been utilised as a screening tool for some time. The immunoassay technique is a popular choice for the evaluation of various research and diagnostic targets including drugs of abuse testing.
As primary manufacturer of the Biochip Array Technology, Randox Toxicology also provide highly sensitive ELISA kits that are compatible with all microplate processing instruments. Our test menu covers a broad range of drugs of abuse and metabolites including new psychoactive substances, stimulants, analgesics and sedatives. With low specificity, our ELISA kits are available across whole blood, urine and oral fluid matrices. Randox Toxicology develop the highest quality 96-well microtitre plates available on the market, with results providing excellent correlation with confirmatory methods.
Our range of ELISAs are precoated with our own antibodies which are cultivated in the UK. The ready to use reagent format facilitates optimum laboratory efficiency and allows up to 80 samples to be analysed in 2 to 3 hours with ELISA procedures.
* EXCLUSIVE to Randox Toxicology
For more information on our ELISA solutions email info@randoxtoxicology.com to be put in touch with a sales member in your area or visit www.randoxtoxicology.com.
We Are Randox | ‘Tis the Season of Giving at the Christmas Raffle 2018
This year our much-anticipated Christmas Raffle took place on Monday 24th December 2018, in aid of our official charity partners, AWARE NI and Mind Your Mood.
The main depression charity for Northern Ireland, AWARE has an established network of 24 support groups in rural and urban areas across the country, and also delivers mental health and well-being programmes into communities, schools, colleges, universities and workplaces. Mind Your Mood is an initiative designed and managed by students at Ulster University to help break down the stigma of mental health and encourage students to access support.
Did you know that the prevalence of mental health conditions in Northern Ireland is up to 25% higher than in England, with anxiety and depression being the most common mental disorders? We’re proud therefore to be supporting both AWARE and Mind Your Mood with a range of fundraising initiatives this year, including now the Randox Christmas Raffle 2018, at which, we are delighted to announce, we raised more than £2500 – with the official total still to be counted!
Congratulations to all our prize winners from this year’s Christmas Raffle, and in particular to the lucky winners of our most coveted prizes – a 55″ Ultra HD 4K Sony Bravia TV and an extra day of annual leave!
Randox Food Diagnostics Screening for Coccidiostats
Feed additives are important in modern agriculture and a focus of the European Union (EU) framework. Whilst such products are used to improve the characteristics of feed, any company wanting to use feed additives for the EU market must obtain prior authorisation, during which the European Food Safety Authority (EFSA) evaluates the safety and efficacy of each additive. The European legislation on animal feed ensures that feedstuffs are suitable for human and animal consumption, whilst not damaging the environment.
Coccidiosis is a disease caused by coccidian, which multiplies in the intestines. In the acute form death of a bird can occur in five to seven days, whilst the chronic type does not kill immediately but persists for a long period of time. To prevent infection, farmers may administer prophylactic antiprotozoal coccidiostats in feed, which increases the chance that coccidiostat residues are retained in both poultry meat and eggs.
However, coccidiostat levels in poultry have increased significantly over the past 3-4 years, causing concern among various groups including Save Our Antibiotics. To reduce the risk of toxicity to consumers, regulatory authorities have set Maximum Residue Limits (MRLs) recommending an appropriate withdrawal period prior to slaughter.
The Randox Food Diagnostics coccidiostats array utilises Biochip Array Technology to quantitatively test for multiple analytes including lasalocid, nicarbazin and imidocarb simultaneously. Revolutionising screening practices, Biochip Array Technology is designed to work across a wide variety of matrices and provides up to 44 results in under 3 hours, saving the user both time and money compared to other screening methods.
For more information on our extensive test menu and coccidiostats array email us directly at: info@randoxfooddiagnostics.com
