RTS: The Dangers of Psychoactive Substances
RTS: The Dangers of Psychoactive Substances
Psychoactive substances, formerly known as legal highs, are substances which produce the same or similar effects as many illegal drugs such as cannabis, ecstasy and cocaine. With many psychoactive substances it is extremely difficult to know their potency and therefore how they will affect the user.
They are divided into four main groups:
Sedatives – Cause reduced concentration and slowing of reactions, leading user to feel physically unsteady and lethargic.
Hallucinogenic – These substances cause psychedelic reactions which can lead the user to act erratically, putting their own safety at risk.
Stimulants – Substance temporarily causes increase in alertness and energy, while also putting a strain on the nervous system.
Synthetic Cannabinoids – Large doses can lead to life-threatening intoxication. Also effects the central nervous system causing seizures, high blood pressure, rapid heart rate and increased body temperature.
Incidents
Last month two men were arrested and jailed for four and a half years for selling psychoactive substances. The offences were committed in Scotland and eight of the men’s customers needed hospital treatment after taking the substances.
Free samples and loyalty cards were used by the men selling the psychoactive substances and two users were left in comas after taking a substance known as Psyclone. Court was told that the shops took in as much as £2,500 in sales every day.
The sister of a man who died from taking psychoactive substances said it changed her brother “mentally and physically.” BBC Scotland was told that he started dabbling with psychoactive substances because he believed they were legal. “Some of them were a substitute of heroin, others to mimic the effects of cannabis. He became very withdrawn with the family and just wanted to stay away.”
Randox Testing Services
At Randox Testing Services we reacted to the issues caused by psychoactive substances by releasing the world’s first Synthetic Cannabinoids (JWH/AM) and ‘Bath Salt’s’ (MPDV) tests in 2012. This enables companies to test for popular types of psychoactive substances and showed that it was possible to detect these substances.
However as new psychoactive substances emerged new tests also had to be created and next generation Synthetic Cannabinoids tests (UR144 and JWH250) were released in 2013. These tests represented a milestone in the fight against the highly dangerous psychoactive substances and provided a way for laboratories and companies to stay on top of the developing drug trends.
Psychoactive Substances we currently screen for;
Today, in the endless pursuit of creating innovative tests for new and emerging psychoactive substances, our expertise sets us apart from the rest of the industry. We will continue to develop our test menus and grow our range of tests.
For more information contact us today at testingservices@randox.com.
We Are Randox | Christopher McNally climbs the career leader from Placement to PhD
The name Christopher McNally may be one that you already recognise. In 2016 he earned 1st place in the Science category of the Randox Pinnacle Placement Awards, having caught the attention of Senior Management for his pioneering work developing a new diagnostic for pancreatic cancer.
Fast-forward two years and Christopher is now back at Randox as a PhD student, conducting research in prostate cancer as part of the recently-announced Randox-Ulster University PhD Academy.
We sat down with Chris to hear all about his revolutionary prostate cancer project, what motivated him to sign up to our PhD Academy and what it’s like to be back in the place where his scientific career began.
Here’s Chris’ story.
I came into Randox when I was just 19 years old for my third year at university as part of the company’s year-long placement programme. It was a great way to truly experience a working laboratory outside of the classroom and really cemented my desire to work in biomedical science.
I was lucky enough to be placed in the company’s Donegal branch, Randox Teoranta, which is close to where I grew up in Gartan, and offered me the opportunity to carry out ground-breaking medical research surrounded by my home of Donegal.
I would highly recommend the opportunity to perform an industrial placement to anyone. It helps you to prepare for what comes after university, develops your skills in the area in which you are interested, and refines your laboratory techniques. I was delighted to hear I won in the Science Category of the Randox Pinnacle Placement Awards during my time there as well, and this really inspired a confidence in me that I had become a talented scientist even before I graduated.
When I completed my fourth year of studies at Ulster University, I graduated with a degree in Biomedical Science and Professional Practice, and returned to work for Randox. The traits and qualities I learned during my placement had subsequently brought me to post-graduate employment, and I was thrilled. I was lucky enough to be able to walk straight back into the lab knowing exactly what to do and how to do it.
Despite becoming employed within Randox straight out of university however, I had this feeling that I was not finished with regards to academic study. I knew I wanted to do more, to perform more research. So, when I heard about the Randox-Ulster University PhD Academy I really was intrigued. It was the perfect platform to further my studies and be able to give more to the scientific community.
When choosing the area of research for my PhD I was keen to hear more about a collaborative prostate cancer project led by two of Northern Ireland’s leading cancer researchers Dr Mark Ruddock (Randox) and Dr Declan McKenna (Ulster University). From my time at university and my time spent at Randox, I thought I could bring my experience and knowledge in cancer research into this project, so I thought, let’s go for it.
Ultimately, the project involves looking at prostate cancer patients as well as patients who have other non-serious prostate conditions, and recognising any potential differences in the two. We can then develop a clinical diagnostic test that can identify the men at the highest risk of prostate cancer and stratify the patients accordingly.
The earlier we can do this, the quicker a patient can be treated, or not treated as the case may be. Overdiagnosis is a significant problem in prostate cancer care and many men, who do not have prostate cancer, but present with prostate cancer-like symptoms, unfortunately go through invasive, uncomfortable and most importantly, unnecessary procedures.
This work therefore has real potential to improve the management of prostate cancer, which is currently the most common cancer in males within the UK. It’s a very rewarding field to be working in and I thoroughly enjoy the work I’m doing knowing that it will have a real-life impact on many men. I’m very proud to be able to say that my PhD research will really make a difference and I now know for certain that I will continue working in cancer research after my project is complete.
Knowing that I’m helping to improve the quality of patient’s lives brings a great deal of satisfaction that few jobs can replicate and I’m excited to see what the next three years will bring.
We’re very proud of Christopher and the amazing work he is doing in prostate cancer research, and are delighted that he has made the decision to join the Randox-Ulster University PhD Academy.
For more We Are Randox stories about our amazing colleagues, make sure to follow us on Facebook, Instagram and Twitter and follow the hashtag #WeAreRandox.
For current vacancies in our team, visit careers.randox.com
To find out more about the Randox-Ulster University PhD Academy, please email randoxpr@randox.com
June focus: Women’s Health
Randox is dedicated to improving health worldwide. Throughout the month of June we hope to highlight how the Randox clinical product range can ensure accurate and swift diagnosis and, by doing so, improve women’s health. We can do this by allowing for necessary steps to be taken post-diagnosis. A common-held misconception is that breast cancer is the biggest threat to a woman’s health, however, the biggest health risk to women statistically is heart disease which accounts for roughly 27% of female deaths. The Randox clinical product range offers a wide range of products to combat heart issues including the RX series extensive cardiac testing panel, reagents such as H-FABP, Adiponectin an TxB Cardio and an extensive cardiac QC range available in both liquid & lyophilised format.
Randox Reagents
Randox Reagents have the highest quality reagents on the market and a test menu comprising of over 118 assays covering over 100 disease markers. Several of these reagents will play a key role in diagnosis in women such as Randox’s Lipoprotein (a) – Lp(a) test, The Randox Lp(a) offers swift and accurate diagnosis of elevated circulation Lp(a) levels which is significant for women as they have an increased risk of CVD due to elevated levels of Lp(a). Several traditional CVD risk markers, including elevated LDL may be absent in some women, elevated Lp(a) levels may identify women at high risk of developing CVD.
RX Series
The RX series range of clinical chemistry analysers offers the most comprehensive testing profile for assessing health in males and females. Urinary tract infections are more commonly found in women and the RX series extensive renal function panel will provide clarity in terms of a woman’s urological health by testing for 19 separate analytes, including microalbumin. The RX series microalbumin test can detect very low levels of albumin in urine and if albumin is detected it can be an indicator of kidney injury and can result in irreversible damage. To view the full RX series test menu click here.
Quality Control
The Randox Acusera Maternal Screening quality control is the only commercially available control which covers all six analytes used during first and second trimester screening of Down’s syndrome and Spina Bifida. Instrument-specific target values and ranges are provided for AFP, Inhibin A, PAPP-A, β hCG, Total hCG and Unconjugated Estriol. The inclusion of PAPP-A and Inhibin A eliminates the need to purchase additional controls at extra expense.
RIQAS
The RIQAS Maternal Screening EQA programme is designed to monitor the performance of screening tests used during the first and second trimester of pregnancy to assess the risk of Down’s syndrome, Spina Bifida and Trisomy 18. 100% human serum ensures commutability while the lyophilised material allows for enhanced stability. Monthly reporting allows laboratories to become aware of issues and remedy them early.
Discussing Companion Diagnostics with Dr Miguel Quesada-González
You may have heard of Companion Diagnostics. This type of diagnostic provides information that is essential for the safe and effective use of a corresponding drug or biological product. It can help to stratify groups of patients which will respond safely to a clinical drug trial, and those who may suffer undesirable side effects.
But why are Companion Diagnostics useful?
Randox Biosciences Pharma Relationship Manager Dr Miguel Quesada-González, PhD has the answer.
“As part of my new role, I’ll be supporting drug development and clinical trials. So as a scientist by background (the nature of the beast) I’ve been reading into and researching this incredibly interesting area of science.
“Since Day 1, Companion Diagnostics (CDx) especially caught my eye.
“When it comes to new drug development, either for Pharma or Biotech, there are many benefits of running a CDx. Based on well-acknowledged scientific papers that I have read, and my own personal perception of the current situation, I’d like to summarise and simplify in just 2 bullet points, what I personally believe to be the most important benefits of running a CDx.
“(a) Delivering the right treatment to the right patient at the right time.
“We should never forget that our priority is the health and integrity of patients. It’s been proven that patients who have similar diagnoses very often respond differently to the same treatment. This variability presents a risk in both the efficacy of the treatment and the safety of the patient.
“The development of a drug is already a risky, long and costly process, so wouldn’t you like to avoid the initial high risk by having a good defined target initially?
“(b) Saving time.
“Money is valuable but time even more so. Time is precious and priceless. Once it’s gone, there’s nothing we can do about it!
“The smaller and more targeted the clinical trials are, the less time and resources you’ll be spending. Normally, the CDx is not initiated until a drug has reached the later stages of development, but, actually, if you put the CDx in place at early development stages (preclinical) it presents many advantages because it enables the selected biomarker to be validated and determined before large amounts of resources have been put in place.
“The faster a potential treatment is developed and approved, the more people you can save, cure or simply improve their quality of life.”
For further information on Companion Diagnostics from Randox Biosciences please email us at info@randoxbiosciences.com
Randox and Ulster University to invest £5m in new Industrial PhD Academy
Randox Laboratories and Ulster University have launched a £5 million skills development initiative to support up to 10 individuals annually through PhD level study in the Life Sciences sector.
The Randox-Ulster University-Industrial PhD Academy, which aims to encourage the development of advanced, higher level skills in key industry sectors, will further reinforce Ulster University’s position as one of the top universities for biomedical related research impact and, enhance Randox’s competitiveness in the growing global healthcare sector.
Up to ten PhD researchers will be supported annually, including Randox employees and individuals from the wider sector, who are working on a range of scientific projects, with the ultimate goal of new product development. They will have the opportunity to work on new research projects, driven by industry and jointly supervised by Ulster University and Randox, to enhance their own individual skill sets whilst delivering groundbreaking advances in the life sciences sector. Ulster University and Randox will each fully fund up to five PhD researchers annually.
To date PhD researchers enrolled in this new programme of Industrial Research have started exciting projects in areas of medicine including mental health, diabetes and cancer, with more projects being developed. All projects share the common goal of delivering new diagnostic approaches for early detection of disease and earlier intervention where possible.
Professor Alastair Adair Deputy Vice-Chancellor Ulster University said:
“Ulster University is renowned globally for research in personalised medicine, cancer, diabetes and mental health and this makes us the perfect fit for a global industry leader like Randox. Ulster University and Randox have a longstanding partnership built around research, knowledge sharing and collaboration which has placed both organisations at the forefront of diagnostics and health research globally.”
Ulster University Professor of Personalised Medicine Tara Moore, said:
“The life sciences sector is of critical importance to our economy and health. To truly maximise our contribution to the economy and to fully exploit new advances in science and technology we must focus on advancing the skills of our workforce, ensuring the most talented people reach their full potential by working with partners to tackle new challenges and drive new discoveries. A strong and growing life sciences sector ensures patients will continue to benefit from new technologies which will help to improve diagnosis getting them the treatment they need quickly.”
“This new Industrial PhD Academy is a further step forward in our commitment to respond to national priorities such as the Industrial Strategy, aligning the research community with industry to drive innovation, building on the world-leading reputation of Randox and supporting a new generation of researchers in this strategically important sector.”
Dr Peter FitzGerald, Managing Director of Randox Laboratories, said;
“At this time of rapid and significant change in the UK, it is critical that the next-generation can meet industry’s ever-changing demands. The current STEM skills shortage costs the economy £1.5bn/year and will only be resolved if all companies in the sector recognise they have a role to play now too.
“In the last 4 months, we have made significant investments within Northern Ireland, in both R&D infrastructure and now in helping aspirational scientists at Ulster University to develop the critical skills to make a positive difference to patient healthcare around the world. We are unapologetically ambitious in our determination to cement Northern Ireland’s reputation as a global hub for life sciences and our own position as a worldwide leader.”
For further information about the Randox UU PhD Academy please contact Randox PR by email: randoxpr@randox.com or by phone: 028 9442 2413
The Evidence Evolution – The newest member of the Evidence series
Launched in 2016, the Evidence Evolution has set new standards in the world of clinical, forensic and food testing.
With the most extensive test menu on offer, we can provide more tests than any other supplier and we are continually investing in R&D to keep up with industry developments and challenges, such as our extensive clinical test menu with a range of routine and novel tests including our CKD panel which detects the early stages of Chronic Kidney Disease.
The Evidence Evolution utilises Randox’s cutting-edge Biochip Array Technology, offering diagnostic testing from a single sample. The Evidence Evolution boasts 2640 tests per hour and when put to the test against our competitor machines, the Evidence Evolution gives a true walk away time of up to 2 hours, meaning staff can fully load the machine and get up to 44 results from each sample every minute, while they get on with important laboratory tasks.
The Evidence Evolution has been designed to meet the needs of a variety of laboratories. Delivering quality results, efficiently and economically in forensic and clinical immunoassay locations.
The Evidence Evolution is the latest development in our Evidence Series range, which was first launched in 2002. This trusted technology is powered by Biochip and is used throughout the world in a range of different sites for clinical, toxicology and food testing. The Evidence Series has a range of analysers that can meet the need of any laboratory.
For more information on any of the Evidence Series analysers, please visit https://www.randox.com/evidence-series/ or contact us evidenceseries@randox.com.
We Are Randox | Digital tourism to sheep dipping – secret of success at Randox Placement Awards
An Ulster University marketing student has won the top spot in global healthcare manufacturer Randox Laboratories’ annual Student Placement Awards.
Matthew Steele from Bushmills fought off stiff competition from fellow placement students in science and engineering programmes by attracting the judges’ attention for the work he carried out within two new and novel ventures taken on by the company.
In recent years, the founder of Randox Laboratories, Dr Peter FitzGerald, has extended his business portfolio to include the Bushmills-based Dundarave Estate and Cherryvalley Farm in Crumlin. Matthew’s focus has been to develop and promote tourism activities at the Estate, such as clay pigeon shooting, as well as Cherryvalley Farm produce. He worked with the company’s IT department and Finance team to complete various projects and created a digital communications strategy.
Additionally, when Matthew was faced with the familiar catch-all that employees may find themselves asked to carry out additional tasks, he won plaudits within the company for stepping in to dip sheep on one occasion!
Speaking after the awards ceremony Matthew commented;
“Placement has been amazing for me and I would encourage everyone to do it. The year has gone so quickly, because you get thrown in straightaway. You’re not seen as a placement student – you’re a member of staff right from the start. This experience has given me so much, widening my business knowledge and teaching me so many new skills. It’s been great.”
Department winners in the engineering and science placement programmes are respectively Ulster University student Dale Love from Ballymena and Jamie Boyd, a Queen’s University Belfast student from Cookstown.
Across the company, 39 university students took part in this year’s placement programme. Lasting 50 weeks, the initiative provides young people with the experience needed to pursue a career in their chosen field.
Linda Magee, Head of Randox Human Resources, commented;
“We are delighted for all our winners in this year’s placement awards. Matthew, in particular, impressed us with creative and successful strategies, and the wholehearted approach he brings to working with us. The Randox Placement Programme is one of our most important initiatives, because gaining industry-experience is now critical for young people. Randox is committed to developing meaningful ways of supporting them, and we are encouraged year after year by the calibre of students who apply to join us.”
For further information about the Randox Placement Awards please contact Randox PR by email: randoxpr@randox.com or by phone: 028 9442 2413
Biochip vs ELISA: Which testing platform is right for me?
Biochip Vs ELISA
Randox Toxicology’s latest video series, ‘Biochip Vs ELISA’, highlights our routine and novel ELISA products and how they differ from Biochip Array Technology.
Showcasing the journey and ongoing brand evolution of Randox Toxicology, these videos will help you to discover which method is right for you!
Episode 1: Meet ELISA
Episode 1 “Meet ELISA” uses speed reading to showcase Randox Toxicology’s extensive and ever-expanding ELISA test menu, including our range of New Psychoactive Substances, drugs of abuse, stimulants, analgesics and sedatives. Manufactured in the United Kingdom, our continuous reinvestment in research and development has enabled us to develop a range of exclusive ELISA kits such as, Mitragynine, MT-45, and U-47700 which was involved in the death of the famous singer Prince.
Our cost effective ELISA kits are the highest quality on the market and results provide excellent correlation with confirmatory methods, typically <10% CV.
Episode 2: Meet Biochip
Based on ELISA principles, Episode 2 “Meet Biochip” illustrates Biochip Array Technology as a solid-state device with discrete test sites onto which antibodies specific to different drug compounds are immobilised and stabilised. Moving away from traditional single analyte assays, Biochip Array Technology boasts cutting-edge multiplex testing capabilities for rapid and accurate drug detection from a single sample.
As the primary manufacturers of Biochip Array Technology, Randox Toxicology offer the most advanced screening technology on the market. With the world’s largest test menu capable of detecting over 500 drugs, Randox Toxicology are changing the landscape of drugs of abuse testing.
Episode 3: Biochip Vs ELISA
Episode 3 “Biochip Vs ELISA” gives you the opportunity to hear from a professional! Laura Keery our Senior Research and Development Team Leader gives you a behind the scenes look at our Biochip Array Technology and ELISA products in action at our new Science Park, answering some of those must know questions.
Episode 4: Biochip Vs ELISA 360-Degrees
If you missed it at SOFT-TIAFT 2017, our Biochip Vs ELISA 360-degree video allows you to experience Biochip and ELISA in action.
Discover which method is right for you! #biochipvselisa
For more information about our revolutionary Biochip Array Technology and ELISA kits, email info@randoxtoxicology.com or visit www.randoxtoxicology.com
Contaminated Cereal Products Rejected at EU Borders
In the month of May alone, over 20 cases of feed and cereal based products have been rejected at EU borders after testing positive for aflatoxins with a risk decision level marking of ‘serious’, countries of origin include; Turkey, Egypt, Gambia, U.S, Indonesia, India, Azerbaijan and Spain.
The European Union have set tolerance levels for Aflatoxin B1 at 2 parts per billion (ppb) and total aflatoxins at 4ppb for nuts, cereals and dried fruits.
Aflatoxins are a mycotoxin produced by a fungus and thrive in hot and humid climates. Aflatoxin B1 is the most prevalent among food products and commonly occur among cereals (including wheat, barley, rice and corn) oilseeds (peanuts, almonds, pistachios and other nuts) spices, fruits, vegetables, milk and dairy products.
Screening for Mycotoxins
There are various screening methods available for mycotoxins in food, but few offer the choice of screening for multiple mycotoxins from one sample. Randox Food Diagnostics has created patented Biochip Array Technology (BAT), an immunoassay ELISA based method, to save the feed and cereal industry time and money on testing.
The Myco Array kit range can screen for 3-10 mycotoxins simultaneously from a single sample and depending on the users testing requirements, customisable kits are available.
For more information on mycotoxin screening with Randox Food Diagnostics contact info@randoxfooddiagnostics.com
Randox-sponsored WAAR a roaring success as over 600 take part
The Wild Atlantic Adventure Race (WAAR) boasted another successful competition on Saturday 12th May 2018 as over 600 competitors braved the challenging but exhilarating course.
The event, sponsored by Randox Teoranta for a fourth year and hosted by Naomh Mura GAA club, gave competitors a choice of two courses that included cycling, running and kayaking.
As promised, this year’s Wild Atlantic Adventure Race delivered an incredible display of stamina, strength and perseverance as outdoor pursuit enthusiasts once again completed the demanding 55.5km course or 39km sprint.
The full Wild Atlantic Adventure Race features a 10km run, 42.5km cycle, 2km hike and 1km kayak, starting and finishing at CLG Naomh Muire, Mullaghderg, Co. Donegal. Set along one of the most beautiful natural coastlines in the world, the west coast of Ireland was once again proud to play host to one of the most challenging yet enjoyable races in Ireland, featuring both novice and elite individuals, as well as several relay teams.
Congratulations to Marty Lynch who won the mens’ solo race with a time of 2hrs 22mins 33seconds and to Sonia Knox who won the womens’ solo race in a time of 2hrs 51mins and 11 seconds.
Dr. Ciaran Richardson, Head of Research & Development at Randox Teoranta in Dungloe, said:
“We are delighted to, once again, partner with WAAR. The event is a real test of physical wellbeing and here at Randox, we take our on-going work to promote positive physical and mental health very seriously. In the last few years, our labs in Dungloe have led the way in world-leading diagnostic research in a wide range of areas including Alzheimer’s disease, kidney disease, cancer, gastrointestinal disorders and stroke.
The Wild Atlantic Adventure Race was a great success and we congratulate all the enthusiastic competitors who took part.”
The full list of WAAR 2018 results can be viewed here.
For more information on Randox Teoranta, please contact the Randox PR team at RandoxPR@randox.com or phone (+44) 28 9442 2413.
