We Are Randox | Carole Smythās Girl Guides Adventures
We Are Randox | Carole Smythās Girl Guides Adventures
We’re passionate about celebrating the kindness and generosity of our Randox employees. Each have their own unique and interesting story to tell and many give up their spare time to support their local community and help those in need.
Their compassion and commitment is what makes Randox the successful company it is today, and nobody demonstrates this better than our Logistics Team Leader, Carole Smyth.
Carole volunteers her time as Unit Leader of 2nd Antrim Girl Guides, a group of girls and young women who together, take part in activities designed to help them reach their potential and take an active and responsible role in the world around them.
As we continue our #WeAreRandox series of staff stories, we are delighted to have found out about the work Carole does with the Girl Guides.
We love getting to know the hobbies and interests that make our colleagues who they are, and hope that Carole’s story encourages other members of our team to consider some voluntary work in their local community.
By the sounds of it, Carole thinks it is an incredibly rewarding experience. Here’s her story.
I’ve been involved in the Girl Guides for 11 years now, having been encouraged to join by my sister-in-law Donna.
The organisation is entirely led by volunteers and therefore reliant on people signing up to commit to a few hours a week delivering Girl Guide activities.
My role as Unit Leader of 2nd Antrim Guides, along with two other leaders, is to ensure the girls have a varied programme and can gain access to activities they wouldn’t normally have access to. This can vary from arts and crafts to science workshops, cooking to camping, and dancing to orienteering.
Each activity aims to promote skills in the likes of leadership, listening, sharing and above all, developing the courage to take on new adventures and exciting challenges.
And it’s not just the girls who get the chance to embark on these adventures. Given my fear of heights, zip lining wasn’t exactly high up on my to do list, but when you have a group of Guides giving you “gentle” encouragement, what can you do?
Another highlight with the Girl Guides for me was June last year when I attended the Trooping of the Colour for the Queen’s birthday. Along with a few other leaders and girls, we were given access to the Youth Enclosure at the entrance to the Horse Guards Parade – a prime viewing spot to see the Royal Family. Then we were escorted to Buckingham Palace up the Mall, and even made it on to TV (if you don’t blink at that specific 0.1 second moment!)
The whole procession was just amazing and it was so special to be able to share this memory with my two daughters, one of whom is a Rainbow (ages 4-7) and the other a Brownie (ages 7-10). As a parent, I love that through Girl Guiding they have the opportunity to meet girls from other backgrounds and beliefs, and as I mentioned before, learn new skills and take part in lots of different activities, as well as earn Guiding-specific awards. From First Aid and World Cultures to Singing and Chocolate (yes you can gain a Chocolate badge – what’s not to love?), all of these awards look great on the girls’ CVs or university application forms.
And if you volunteer to be a leader, you can also study for new qualifications – in first response, hiking, catering or Duke of Edinburgh, to name but a few. Personally though, my favourite thing about being a Girl Guides leader is the opportunity to see the girls grow and develop during their time with us. I am able to witness shy girls gaining more confidence, girls with learning difficulties or health complications taking part in different activities that they would normally shy away from, and in general, just seeing all our girls enjoying their time together and making lasting friendships.
It sounds corny but I myself have also met lots of fantastic leaders during the last 11 years who I can now call lifelong friends. The bonds we as leaders, and the girls, make when we go away on our annual day trips, overnight stays, and camping adventures are quite unique.
This year our unit is attending an outdoor camp (our first overnight outdoor experience!) along with other units from our county. Last year, we took our Guides to Dunluce Guide House for our unit holiday and enjoyed a spot of horse riding, and last November we took part in UK Parliament Week by attending an evening at Stormont, where we met Arlene Foster. A few of our girls also took part in an activity day organised by Ulster Rugby at which they learned some basic rugby skills and had the opportunity to interact with Guides from all over Ulster.
The activities we offer to our Girl Guides are truly once-in-a-lifetime opportunities and I am proud that I am part of such a special organisation.
We’re very proud of Carole and the amazing work she does with Girl Guides, and are delighted that she has taken the time to share her story with us.
If you would like some further information on Girl Guiding, you can visit www.girlguiding.co.uk to register your interest.
For more We Are Randox stories about our amazing colleagues, make sure to follow us on Facebook, Instagram and Twitter and follow the hashtag #WeAreRandox.
For current vacancies in our team, visit careers.randox.com
Randox Testing Services: The difference between CBD Oil, Cannabis Oil and Hemp Oil
CBD Oil, Cannabis Oil and Hemp Oil are naturally produced from the plant Cannabis Sativa. This article will aim to distinguish between the different variations, and highlights differences in their use, abuse and legal standing.
Cannabis is the name given to the common drug of abuse, made from various parts of the Cannabis Sativa plant that contain a high level of a chemical called THC (tetrahydrocannabinol). THC is the chemical responsible for most of cannabis’s psychological effects. It stimulates cells in the brain to release dopamine and interferes with how information is processed in the hippocampus, the part of the brain responsible for forming new memories. Strains of Cannabis Sativa are specifically bred for their high THC content in resinous glands on their flowers and some leaves.
Cannabis Oil contains a high level of THC and if administered can result in psychoactive effects. There is a growing movement to legalise THC in the form of oils or capsules for medicinal use (pain relief), however, like cannabis itself, it is currently illegal to possess, or supply cannabis oil in the UK.
CBD (or cannabidiol), like THC, is another chemical component extracted from the Cannabis Sativa plant. Unlike THC, CBD is not psychoactive and does not produce a ‘high’. CBD is derived from a specific hemp strain that is high in CBD and low in THC and is extracted from the whole plant (and not just the seed like hemp seed oil). The use of CBD oil is becoming widespread for its reported health-giving benefits. It is perfectly legal to use (because it contains negligible amounts of THC) and can be purchased from health food shops and on-line.
However, it is also sometimes (mistakenly) referred to as ‘cannabis oil’ which causes confusion.
Hemp is a fast-growing strain of Cannabis Sativa specifically bred for its fibre (for textile use), oils (including CBD oil) and nutritional benefits among its ever-expanding range of uses. However, hemp is bred to be low in THC. Hemp seed oil is acquired by pressing the hemp seeds only and contains neither THC nor CBD. Hemp oil is perfectly legal and you may find it in some health food products or even beauty products.
Effects of Cannabis
Cannabis is the most commonly abused drug in the UK and can produce a range of side-effects including an increased risk of developing a psychotic illness. For an extensive list of the side-effects of regular cannabis use download our free educational resource: http://www.randoxtestingservices.com/download/Effects-of-Cannabis-Poster.pdf
About Randox Testing Services
Randox Testing Services is a market leader in the drug and alcohol testing industry. Our expertise is relied upon by a range of leading safety-critical companies across the world.
We pride ourselves on helping our customers improve the health and safety of their working environment through helping them implement a comprehensive substance misuse policy. As experts in our field we ensure that we are aware of current drug trends and issues that are affecting society.
Contact us today at testingservices@randox.com or call 028 9445 1011 to speak with one of our experts.
The Importance of Equine Health
With the Grand National around the corner, Randox Reagents have investigated the importance of equine health, focusing on racehorses.
Maintaining good health in racehorses is vital as proper management can reduce the incidence of many disease conditions. Racehorses are bred, raised, and trained to perform as athletes. Therefore, it is vital that the performance health of racehorses is continually assessed to ensure that they are physically fit, happy and healthy.
Racehorse’s have a busy life. They are broken in from 18 months of age, usually using traditional methods such as long reining, followed by accepting a rider and training alongside other horses. At 2 years of age, the real training begins which focuses on fitness and speed rather than ‘schooling’ the horse in the conventional way. This training is undertaken alongside another horse to teach the trainee horse how to race but at the same time, it is taught to settle and listen to the jockey.
In peak season, the horse’s weekly exercise regime consists of: two days of fast gallop work with steady trotting or cantering the rest of the week, with a rest day on Sunday’s (depending on races scheduled for the horse).
The most important bodily systems for top athletic performance in racehorses include:
Skeletal system (including bone, tendons and ligaments) problems such as torn or stretched ligaments or tendons or a broken bone will be very painful, inducing lameness and prohibiting performance
Muscles enable the horse to perform. Fatigued or damaged muscles will result in poor performance as the horse cannot generate enough energy and strength to maintain its high performance
Respiratory system (nasal passages, throat and lungs) problems prohibits the normal flow of oxygen through the body, which prohibits the energy required for exercise
Cardiovascular system (heart, blood vessels, volume of blood and red blood cells) problems prohibits the movement of oxygen from the lungs to the muscles, again prohibiting the generation of energy required for exercise.
Central nervous system (CNS) problems can result in the loss of coordination and the fine control that accompanies minor problems to the CNS can significantly prohibit exercise performance
Due to the intense training that racehorses undergo, it is vitally important that their health is continually assessed to diagnose and treat injuries and the jockey allows the horse time to recover from the injury. The most common sites of injury include: forelegs, back and pelvis such as bowed tendon (tendonitis), strained suspensory ligaments, splints, osselets, sesamoid fractures, condylar fractures, knee fractures, bone chips, bucked skins and pin firing. It is vitally important that racehorses are allowed time to rest and heal after an injury. Training or racing a horse whilst injured can be detrimental.
Randox Equine Panel
Randox offer 10 scientifically proven assays for equine health which are made from the same high-quality material as our human assays, providing accurate and precise results. These assays have extensive measuring ranges for the accurate detection of disease or inflammation which are suitable for use with serum, plasma and whole blood. Instrument specific applications (ISA’s) are available for an extensive range of biochemistry analysers suitable for use with manual, semi-automated and fully automated analysers.
The Randox range of assays, suitable for equine use, cover a range of biomarkers:
Adiponectin is used to assess equine metabolic syndrome (EMS) which is characterised by obesity, regional adiposity, insulin resistance, and susceptibility to laminitis. Laminitis is one of the most common causes of lameness in horses. It is a painful and potentially crippling condition, which in severe cases usually results in the horse being humanely euthanised.
Aspartate Aminotransferase (AST) levels directly correlate with the severity of muscle inflammation or damage, or liver damage. The highest levels of AST will be seen around 24hours after muscle injury and persist for 2-3 weeks.
CK-NAC is a sensitive marker for the detection of musculoskeletal diseases; and is useful to assess the extent of severe muscle trauma, crush injuries, and burns and the likelihood of developing rhabdomyolysis.
For health professionals
If you are a veterinarian or laboratory who are interested in running equine assays, Randox offer a wide range of high-quality routine and niche assays including: albumin, alkaline phosphatase, bilirubin, calcium, GLDH, glucose and urea. These can be run on most automated biochemistry analysers.
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
For more information, email reagents@randox.com
How Randox is helping to diagnose metabolic conditions
Metabolic health is a term used to describe a collection of required chemical reactions that take place in all living organisms. A metabolic disorder develops when an abnormal chemical reaction occurs which alters the normal metabolic process.
A common misconception surrounding metabolic health is that it refers solely to your weight, and if you are overweight you are considered to be unhealthy. But in actual fact this may not be entirely true. Good metabolism means that your body is in good overall health, which doesn’t account for just your weight! Common metabolic disorders include genetic metabolic disorders, diabetes and metabolic syndrome. Understanding and testing to see how well your metabolism is functioning is key to ensuring long lasting health.
Genetics
There are a number of genetic metabolic disorders caused by mutations of single genes. Examples of common disorders include Gaucher’s disease, hemochromatosis and cystic fibrosis. Gaucher’s disease is a genetic disorder that affects the body’s ability to break down fat that can accumulate in the liver/spleen and bone marrow. Hemochromatosis is a condition that is caused by the over-absorption and build-up of iron while cystic fibrosis is a metabolic disorder that appears as a result of a build-up of mucus in lungs/liver and intestines. Each of these metabolic disorders affect certain organs from functioning properly and therefore your overall healthiness.
Diabetes
Type 2 diabetes is one of the most common types of metabolic disorders in the world that is expected to affect 592 million people by 2035. It is characterised by high blood sugar, insulin resistance or a lack of insulin being produced by the pancreas. Insulin resistance occurs when the body isn’t able to use insulin the right way which increases blood glucose levels. Insulin is needed for cells to take in glucose (sugar) from the bloodstream and convert it into energy. Over time this lack of insulin can damage the organs in your body.
Metabolic Syndrome
Metabolic syndrome (also known as syndrome X, Reaven’s syndrome, and CHAOS) is not a disease but a collection of risk factors that affect your health; these include high blood pressure, high blood sugar/cholesterol and abdominal fat. Left untreated, these risk factors, together, can lead to long term serious problems including an increased risk of heart disease, stroke and developing type 2 diabetes.
Can you improve your metabolic health?
Yes! The good news is that if you discover that your metabolic health is not up to scratch you can improve it through a combination of diet, exercise and lifestyle adjustments such as:
- 30 minutes of moderate to intense exercise 5-7 times a week
- Low-dose aspirin to reduce your risk of stroke or heart attack
- Quit smoking
- Medication for blood pressure/cholesterol/ blood sugar
- Limit alcohol intake
- Eat a healthy balanced diet
Related Products
Randox has developed the RX series of clinical chemistry analysers for superior semi-automated and fully automated testing. The RX series extensive dedicated test menu goes beyond routine testing and has many unique and high-performance tests available. Our range of tests covers several parameters to assess your overall metabolic health.
Metabolic Health Profile
| Albumin | Chloride | Potassium |
| Alkaline Phosphatase | C02 Total | Sodium |
| ALT | Creatinine | Total Bilirubin |
| AST (GOT) | Glucose | Total Protein |
| Direct Bilirubin | Lactate | Urea |
| Calcium |
The RX series clinical chemistry analysers provide laboratories with a robust and smart solution ensuring you maintain a consistent workflow and can provide accurate results first time, every time. Offering excellent customer support services, our trained engineers are on hand to work with you in preserving the continuity of your operations while maximising the potential of your RX series instrument. Our world-famous test menu of high quality reagents ensures excellence in patient care, guaranteeing unrivalled precision and accuracy reducing costly test re-runs or misdiagnosis and offering complete confidence in results.
For more information visit: https://www.randox.com/clinical-chemistry-analysers/
Benefits of High-Sensitivity Troponin I (hs-TnI)
Benefits of High-Sensitivity Troponin I (hs-TnI)
Chest pain is a common symptom; 20% to 40% of the population will experience chest pain during their lifetime. There are many causes of chest pain, some of which are benign, while others are potentially life threatening. Importantly, in patients with chest pain caused by an acute coronary syndrome (ACS) or angina, there are effective treatments to improve symptoms and prolong life, emphasising the importance of early diagnosis in patients where chest pain may be of cardiac origin (Skinner et al, 2010). Chest pain is one of the most common reasons for emergency admission to hospital and is a heavy burden on health-care resources. A strategy to identify low-risk patients suitable for immediate discharge would have major benefits (Shah et al., 2015).
RIQAS Liquid Cardiac Programme
Interlaboratory data Management
Ford, C. (2017). Benefits of High Sensitivity Cardiac Troponin I at Admission. Clinical Laboratory Management Association, (July/August 2017), 22-24.
Shah, A., Anand, A., Sandoval, Y., Lee, K., Smith, S., & Adamson, P. et al. (2015). High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study. The Lancet, 386(10012), 2481-2488. http://dx.doi.org/10.1016/s0140-6736(15)00391-8
Skinner, J., Smeeth, L., Kendall, J., Adams, P., & Timmis, A. (2010). NICE guidance. Chest pain of recent onset: assessment and diagnosis of recent onset chest pain or discomfort of suspected cardiac origin. Heart, 96(12), 974-978. http://dx.doi.org/10.1136/hrt.2009.190066
Determining your True Body Age with Randox Health
How much do you know about metabolic syndrome?
It is often mistaken for diabetes, but the truth is, metabolic syndrome is a cluster of conditions – including increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol. When these occur together, your risk of heart disease, stroke and diabetes is increased.
Determining whether or not a patient has metabolic syndrome is a complex process, with basic measurements including height and weight, as well as tests for insulin, leptin (a hunger-suppressing hormone) and adiponectin (a hormone inversely related to dangerous internal fat) factoring in to a comprehensive scientific investigation.
The first step in this investigation is often a test for Basal Metabolic Rate (BMR), which is the rate at which the body consumes calories for basic bodily processes – eg. maintaining internal temperature, repairing cells, pumping blood and powering muscles.
With the results of your Basal Metabolic Rate at hand, the scientific team at Randox Health can then present you with your Metabolic Age, or True Body Age as it is often known, by comparing your best Basal Metabolic Rate to other age groups.
The result is relative to gender, age, height and weight and other lifestyle factors. Increased BMR can be the result of frequent physical exercise, stress, illness, diabetes or hyperthyroidism (an overactive thyroid gland), whereas decreased BMR can be associated with old age, loss of lean body mass or hypothyroidism (an underactive thyroid gland). Certain drugs, for example antidepressants, and menopause, can also affect BMR.
If the age indicated is lower than your actual age, then congratulations! With your healthy living habits, you have managed to shave years off your age. If the result is higher than your actual age, then you may need to increase your exercise levels or review your diet to improve your results.
And therein lies the good news. With changes to diet and exercise, you can prevent or even reverse metabolic syndrome.
And that’s why it’s so important to find out the status of your health at the earliest possible stage – so that you can make the necessary changes to your lifestyle before you develop a more serious condition.
At Randox Health events across the country, including this year’s Randox Health Grand National, our team of scientists are offering free ‘True Body Age’ results on their Body Composition Analysis machine, which assesses 25 different areas of your body. It takes measurements including ratio of muscle to fat, bone density, hidden visceral fat and cellular hydration levels.
In its measurement of Basal Metabolic Rate the BCA machine will give challengers their True Body Age, which can be a great way to kickstart your health improvement journey.
It is however, only the first step in obtaining a comprehensive understanding of your current health, and determining the conditions of which you are personally at risk of developing in the future.
Randox Health goes beyond standard testing – offering the world’s most comprehensive and personalised health check. Following your initial Body Composition Analysis and True Body Age reading, our scientific experts will then analyse up to 350 different results from a blood sample you provide. Armed with the knowledge of your results, you can truly take control of your health and make a change to improve your future wellbeing.
Phone the Randox Health team today to make a booking: 0800 2545 130
Or join us at the Randox Health Grand National for a FREE Body Composition Analysis which will tell you your True Body Age.
Extreme Weather Results in High Risk of Mycotoxin Contamination
Mycotoxin contamination is a real and constant threat for feed and animal compound producers globally. Recently the University of Guelph, Guelph, Ontairo stated that the different geographical locations of cattle mean between 10 and 20 mycotoxins can be present at once. This is a result of extreme weather patterns across the US with excess moisture and drought in different areas causing an increase in the frequency of mycotoxins, creating challenges in protecting livestock from ingesting contaminated feed.
The most common mycotoxins found are Aflatoxin, Fusarium, Deoxynivalenol and Zearalenone. Aflatoxin is produced by Aspergillus flavus, a tropical fungus that thrives in high humidity and affects an animal’s liver, causing cancer in more extreme cases. Fusarium can develop in most temperate climates across the U.S and Canada. Fusarium poses a higher threat than other toxins as there are hundreds of different chemical structures to analyse to enable identification of the Fusarium.
Difficulties also arise in finding an analytical method sensitive enough to detect mycotoxins at low levels of contamination as small amounts can still lead to fatal results in horses, dogs and cats.
To prevent mycotoxin infection in feed, processors can implement a routine screening procedure with the help of Randox Food Diagnostics. Randox Food offer a multiplex screening system for the simultaneous detection of up to 10 of the world’s most prevalent mycotoxins including: Paxilline, Fumonisins (part of the Fusarium group), Ochratoxin A, Aflatoxin G1/G2, Aflatoxin B1/B2, Ergot Alkaloids, Diacetoxyscirpenol, Deoxynivalenol, T2 Toxin and Zearalenone. All compounds are screened at low limits of detection using Biochip Array Technology.
Biochip Array Technology is a patented technology created by Randox to facilitate the detection of contaminants and drug residues with over 20 evaluated matrices in feed (see full list below).
| Animal Feed (Complete) | Millet | Sunflower |
| Barley | Mustard Seed | Wheat |
| Beet | Palm Kernel | Grass |
| Buckwheat | Rapeseed | Whey |
| Corn/Maize | Rice | Linseed |
| Cotton Seed | Rye | Feed Pea |
| Distillers Grain | Silage | Vetches (Vica) |
| Hay | Soya | Oat |
To learn more about Mycotoxin testing with Randox Food Diagnostics email, info@randoxfooddiagnostics.com
Study by Center for Disease Dynamics finds dramatic rise in global antibiotic consumption
A dramatic increase in global consumption of antibiotics has led public health experts to call for innovative new ways to rein in excessive use of the drugs, following a study by the Centre for Disease Dynamics, Economics and Policy, in Washington DC.
The study found a 65% rise in worldwide consumption of antibiotics from 2000 to 2015, despite efforts to encourage more prudent use of the drugs. The unrestrained use of antibiotics is the main cause of the increasing appearance of drug-resistant infections, which now kill more than half a million people worldwide. A report in 2014 predicted that the spread of drug resistance could claim millions of lives per year by 2050.
Eili Klein, an author of the study, which was published in Proceedings of the National Academy of Science, criticised the global response to the global antibiotic resistance crisis as “slow and inadequate” and called for a “radical thinking” of antibiotic consumption.
At Randox, our pioneering R&D teams have developed a revolutionary swab test for respiratory infections which will help to reduce the unnecessary prescription of antibiotics. Earlier this year, Public Health England reported that 59% of people who visited their GP with a sore throat were prescribed antibiotics, in spite of only 13% actually needing them.
The new Randox swab test indicates the cause of the infection and whether a patient needs antibiotics or not, by rapidly detecting and identifying the cause of 21 respiratory infections in just 5 hours
The test assists the clinician in prescribing the appropriate antibiotic.
John Lamont, Lead Scientist at Randox Laboratories, said;
“Current diagnostic testing for respiratory infections takes at least 36 hours to confirm the nature of an infection, and they cannot name and categorise infections as bacterial or viral in the way our new respiratory test can.”
This test, if widely adopted, could allow medical practitioners to make the correct treatment choice on the same day as examination and before patients have already begun a precautionary course of inefficient antibiotics. It would also have additional efficiency savings for the NHS, by eliminating the need for lengthy microbiology lab tests and unnecessarily prescribing drugs which are not needed.
This new rapid and accurate test will give clinicians confidence in their diagnosis of respiratory infections and will allow for quicker treatment if necessary, which benefits patient outcomes. By reducing the prescription of unnecessary antibiotics, we can limit their use only for when they are truly needed.
The test is also available as a Randox Health Cough, Cold & Flu offering, and can be carried out by booking an appointment with Randox Health at our clinics in Crumlin, Holywood or London, or by arranging the mobile clinic to visit you at your home or place of work.
Book an appointment with one of our clinics, or arrange the mobile clinic, by phoning 0800 2545 130 or by clicking here.
For further information about the Randox Respiratory Infection Array please contact the Randox PR team by email: randoxpr@randox.com or phone 028 9442 2413
Complement C4 – Biomarker for Systemic Lupus Erythematosus (SLE)
Systemic Lupus Erythematosus (SLE) is an autoimmune disorder associated with a deficiency in complement C4. Complement C4 is one of nine components of the complement system which is an integral part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from the host, promote inflammation, and attack the cell membrane of pathogens.
Complement C4 is a vital component of two immunology pathways: Classical pathway and Mannrose Binding Lectin (MBL) pathway.
The classical pathway is triggered by antibody-antigen complexes which induces a conformational change in the C1 complex. The activated C1 complex cleaves the C4 component, resulting in a reactive C4b which covalently binds to proteins or polysaccharides at the surface in close proximity of the C1 component. The bound C4b complexes binds to the C2 component rendering C2 for proteolysis by C1.
The MBL pathway is activated through the binding of MBL to mannose residues on the pathogen surface. This in turn activates the MBL-associated serine proteases, MASP-1 and MASP-2, which activates the C4 and C2 components, to form the C3 convertase, C4b2a. The C4b2a complex splits C3 into two fragments which causes the release of vasoactive mediators such as histamine.
Complement C4 deficiency is commonly associated with systemic lupus erythematosus (SLE).
According to lupus.org, 16,000 new cases of lupus are reported each year. Approximately 1 in 250 people may end up developing SLE at some point with 90% of SLE patients being female aged between 15-44 years. The causes of SLE are unknown, but are believed to be linked to environmental, genetic, and hormonal factors. 1.5 million Americans are living with diagnosed lupus.
There are four forms of lupus:
- Systemic – accounts for approximately 70% of all lupus cases. In half of these cases, a major organ or tissue in the body, such as the heart, lungs, kidneys, or brain will be affected.
- Cutaneous lupus – accounts for approximately 10% of all lupus cases and only affects the skin.
- Drug-induced lupus accounts for approximately 10% of all lupus cases and is caused by high doses of certain medications.
- Neonatal lupus is a rare condition in which the mother’s antibodies affect the fetus. At birth, the baby may have a skin rash, liver problems, or low blood cell counts, but these symptoms typically disappear completely after six months with no lasting effects.
The Randox Complement C4 assay
The Randox Complement C4 assay is used for the quantitative in vitro determination of complement C4 concentration in serum. The Randox Complement C4 assay can be used as a biomarker in the diagnosis and monitoring of SLE. It is the cell-bound levels of processed complement activation products, especially E-C4d (erythrocyte-bound C4) that makes the complement C4 assay a biomarker for SLE.
Key Features of the Randox Complement C4 assay
Liquid ready-to-use reagents – The Randox reagent comes in a convenient liquid format requiring minimal preparation thus reducing the risk of errors.
Exceptional correlation with standard methods – The Randox methodology was compared against other commercially available methods and the Randox Complement C4 assay showed a correlation coefficient of r=0.98.
Wide measuring range – The healthy range for Complement C4 is 7 -49 mg/dl. The Randox Complement C4 assay can comfortably detect levels outside of the healthy range measuring between 2.90 – 152 mg/dl.
Excellent stability – Stable until expiry date when stored at +2 to +8°C.
For health professionals
If you are a clinician or laboratory who are interested in running specific protein assays, Randox offer a wide range of high-quality routine and niche assays including: Cystatin C, Complement C3, CRP, Lipoprotein (a), Apolipoprotein C-II, Apolipoprotein C-III and Apolipoprotein E. These can be run on most automated biochemistry analysers.
Instrument Specific Application (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
For more information, download our Specific Proteins Brochure email reagents@randox.com
Sir AP McCoy and father of late āKing of Heswallā team up for Randox Health Week
Almost a year to the day of the tragic death of the “King of Heswall” Tim Cogley, his father will be joined by some of the UK’s best-known sports stars at an event in Liverpool to raise awareness of how lives can be saved through improving access to earlier routine health screening.
On April 9th 2017 Tim, who was only 34-years old, suffered a fatal heart attack due to a genetic condition which could have been managed had it been diagnosed earlier. It spurred his father, Frank Cogley, to set up a charity to raise awareness of the importance of health checks for young people.
He’ll be joined at the free Randox Health Week event in Exchange Station on 11th April by legendary jockey Sir AP McCoy, champion boxer Paul Smith and Olympic sailor Matt McGovern. The public will be invited to join the discussions as well.
Frank said: “It’s been recently reported that at least 12 under-35s die from undiagnosed heart conditions every week in the UK. The current lack of routine screening of 18-40-year olds leaves a gaping chasm in our healthcare provision. With our highly motivated partners, through events like this, we hope to redress this through lifestyle changes and preventative medical programmes. The ‘Tim Cogley Cardiac Screening Foundation’ is committed to delivering positive, action-focused and life-changing programmes. I can’t imagine a legacy more in tune with the generous, kind and supportive person that was Tim!”
This is the second year that Randox Health Week has been held in the city. The areas of mental health and active cities will be explored on days one and two – the 9th and 10th respectively. On each of the mornings, local athletes Franny Norton and Derry Mathews will be putting pupils to the test with a range of sporting activities at LJMU’s Byrom Street campus.
By working with the city’s leading universities – Liverpool John Moores and Liverpool Hope – cutting-edge innovations in healthcare and emerging trends are being shared with a global audience. One such ground-breaking development is a test for prediabetes which is key to tackling the worldwide threat of preventable cases of Type-2 diabetes. It’s something that legendary jockey Sir Anthony McCoy, also taking part in Wednesday’s talk, has first-hand experience of:
“When I got my first test results back that said I had prediabetes, it floored me. I had never imagined that I, someone who had been a professional athlete all of my life, could develop it. It just goes to show that we’re all vulnerable. I only wish it had been around when it could have helped my mum who lived with Type-2 diabetes for many years. As daunting as it was getting the diagnosis, it’s been empowering to very simply make lifestyle changes to reverse it. This needs to be accessible to everyone – it needs to be on the national diabetes screening programme.”
Dr Peter FitzGerald, Managing Director of Randox Health, commented: “The themes we’re focusing on this week are some of the most important global concerns facing us today – mental health, physical activity and showing people the benefits to being proactive about their health, rather than facing the consequences of preventable sickness. You need look no further than Frank Cogley who is working tirelessly to turn his son’s tragic death into a force for good to see how important this is. With the support from AP McCoy and Paul Smith, we hope this event will inspire many people in the city and beyond.”
Tickets are free and can be reserved at www.eventbrite.co.uk/e/randox-health-week-2018-tickets-43648350391
For further information about Randox Health Week, please contact the Randox PR team by email: randoxpr@randox.com or by phone: 028 9442 2413
