Randox Equine Health Programmes: Keeping racehorses healthy from the paddock to the podium
Randox Equine Health Programmes: Keeping racehorses healthy from the paddock to the podium
As sponsors of the Randox Health Grand National, the welfare of horses is of paramount importance to us and is a cause very close to our own hearts.
Did you know that one of the reasons we entered into partnership with the Jockey Club is because we are experts in the field of Equine Health?
Well now you do!
Not only do we have a history of being involved in equestrian events, (we host the Randox Point-to-Point event for our local community every year, and International Polo Tournaments in both Scotland and Bushmills, on the Causeway Coast of Northern Ireland), but we also have over 34 years’ experience in the diagnostics industry, during which we have developed innovative and accurate diagnostic products for Equine Health.
That may sound complicated but vets, trainers and owners have been working with us for years so that we can help them better understand their horses’ health and wellbeing.
To recognise the importance of what we do, you must know that more than 70% of all medical decisions are based on an analysis of your blood.
Using our innovative blood-science technology we can obtain a comprehensive profile of not only your body’s current health, but also your future health. This is the same for horses!
In the development of our own dedicated Equine Health Programme, we’ve learnt a thing or two. We know that endurance racehorses require extra attention as a result of intense physical exercise, and therefore monitoring what’s going on in their blood is vitally important.
To give an example, monitoring the Total Antioxidant Status of your horse is a sure-fire way to detect whether he or she has suffered muscle cell injury or trauma.
A reduction in the overall antioxidant status of your horse inhibits its body’s defence and monitoring the TAS is therefore an efficient way to identify risk of injury, determine the levels of training required and establish appropriate recovery times to maintain their wellbeing.
If your horse is often transported between locations it’s also important to monitor his or her TAS. The Total Antioxidant Status of a horse may increase after long-haul road transportation, indicating that your horse is stressed.
So, as you can see, you can tell a lot about the health of your horse by looking at what’s going on in their blood. We’re the experts in this area so we can share our knowledge with you, explain the importance of particular biomarkers in observing the health of your horse, and advise you what areas of your horse’s health you should be monitoring if you have particular concerns.
Let’s say for example your horse is undergoing intense training.
We would recommend that you monitor their levels of Superoxide Dismutase. This enzyme can let you know whether they are suffering from any muscle pain, stiffness, joint weakness, loss of muscle strength, stamina and flexibility, amongst other issues. It is important to know whether their current training is regime is benefitting them, or encumbering them.
If injury is suspected, we then advise that you monitor your horse’s levels of Creatine Kinase.
Any damage to your horse’s heart, skeletal muscle or brain tissue will result in a spike of Creatine Kinase in the blood. By monitoring CK, you can determine any muscle trauma, bruising, wasting, abscesses, inflammation, infection and recurring muscle damage.
Laminitis, a painful inflammatory condition of the tissue, is often one of the most concerning conditions for any horse, as historically there has been minimal opportunity to detect the risk or early stages of the disease. Randox Adiponectin, a protein hormone, is now being used in conjunction with other current biomarkers to successfully detect the risk of this disease and allow earlier management of the condition in the aim to remove the risk completely or reduce its life-altering impact.
The importance in monitoring these biomarkers is of course that it enables early treatment, which greatly improves your horse’s prognosis and chances of recovery.
Swift treatment upon diagnosis of trauma ensures that your horse is kept healthy and happy, and our customers agree! We work with a number of key Veterinary Hospitals around the world, including Rood and Riddle Equine Hospital, the Official Equine Hospital of the Breeders’ Cup in Lexington, Kentucky, (known as ‘The Horse Capital of the World!), and The Irish Equine Centre in Kildare, Ireland.
Jean Hearn, Biochemistry Lab Manager at The Irish Equine Centre, commented;
“As a long time customer of Randox Laboratories, over thirty years, I feel I am in a good position to offer an opinion on the company. Initially we dealt with Randox for Chemistry Reagents and ELISA kits, as they offered a very good range for us working in the veterinary field. However when they launched their Randox Daytona, we found it to be an essential additional analyser in our laboratory, due to the fact that it was capable of running tests that prior to that we were running with very labour intensive methods. eg various minerals and it also broadened the range of tests we could offer to our customers ,eg. acute phase proteins.
“Support has always been good from Randox and the staff always very pleasant and helpful.”
Of course what your horse eats plays a huge role in their health too.
High quality horse feed is paramount for race horses in particular whose speed, agility and most importantly, health, is dependent on them receiving all the nutrients they require.
Our Randox Food Diagnostics ensures the safety of horse feed by screening the food for harmful mycotoxins which can grow on a variety of different crops including cereals, grains and fruits, and can cause a number of health issues for horses, including problems with fertility, sports performance and malnutrition.
And our work in the racing industry doesn’t stop there.
Our Randox Toxicology division creates custom testing panels for the screening of drugs of abuse, on our patented Randox Biochip Array Technology, which has revolutionised the diagnostics industry by allowing multiple tests to be run simultaneously on a single, undivided patient sample.
Screening for drug abuse amongst jockeys in this way (we currently work with Jockey Clubs around the world including Sha Tin racecourse in Hong Kong) protects the safety of the horses and ensures races are won on the jockeys’ and the animals’ natural abilities.
Hopefully you now have a flavour for the work that we do in the racing and veterinary industries to ensure the health and wellbeing of horses. We hope that through our sponsorship of the Randox Health Grand National we can share our knowledge and expertise in the field of Equine Health, Horse Feed Screening and Jockey Toxicology with the racing fraternity.
Just as we promote a message of preventive health to racing fans, the same applies to the horses we love.
For further information on how we work to keep horses healthy, please contact our Randox PR Team.
E: nicola.mchugh@randox.com or amy.mcilwaine@randox.com
T: 028 9445 1016
We Are Randox | Charlie Graham tells us about her time spent volunteering in Ethiopia
Here at Randox we are celebrating our creative and talented work force whose fresh perspectives and world experience help Randox operate on such a global scale.
Recently, Charlie Graham, a member of the Randox Food Diagnostics Marketing team told us about her time spent in Ethiopia, volunteering with Volunteer Service overseas (VSO) as part of the International Citizenship Service (ICS) Programme.
Charlie sat down with us to tell us her story.
“I first heard about the ICS program when I was studying at Glasgow Caledonian University. My friend who was also studying Business Management with Marketing alongside me, had pre-warned me about the intense application process, and although it seemed quite daunting at the time, I have always been interested in volunteer work and international travel so I felt up for the challenge.
To be considered for a place on the program I had to firstly complete an online application. Then if you passed this initial stage you were invited to attend a group interview that took place in London. Here I undertook both group and individual assessments throughout the day that tested my knowledge of international development, conflict resolution and team work skills. Surprisingly, I found the interview process extremely rewarding as there was a strong focus on personal development and feedback. It was also interesting to learn about the possible charities that we could be placed with based on our skill sets.
I was excited when I finally received the news eight weeks later that I been matched with VSO and would be placed in a livelihoods development programme in Addis Ababa. To finalise my place I had to raise £800 that would go towards the work that I would be doing when I arrived in Ethiopia. I decided to host a bake sale in the foyer of Caledonian University and also compete a 5KM run to help raise the money.
As a group, we underwent pre-departure training before our flight from London. Once I landed there was a week of in-country training where I met up with the Ethiopian volunteers that I would be working alongside for the next three months. We also met our new families that we would be staying with throughout the duration of the program.
One of the first projects that I worked on was with the Women’s Income Generating Activity Groups. This Government funded program provided both training and guidance for local women who had received a small loan which enabled them to start up their own business ideas. One memory that has stuck with me from working with this group was the power of knowledge. Almaz, the project leader, highlighted that for many of the women learning how to read and being able to sign their own names was truly empowering and allowed them to become financially independent for the first time in their lives. This really brought home to me how valuable the work of ISC is, and how much I as a volunteer was able to impact the lives of these women by teaching them this simple act.
I also organised community action days during my time in Ethiopia. I visited a rehabilitation centre called Mecadonia that housed 170 people aged between 10 – 94 who are bed ridden or elderly. As this centre runs solely on donations we provided meals and clothing for all the residents. I even got a local newspaper to come and write about the centre to help raise awareness and potentially generate new sponsorship for the future.
One of the residents of Mecadonia was called Addis, he was 26 and was in desperate need of a kidney transplant. He had been suffering from kidney problems for five years and his family could only afford to treat him with traditional remedies – nothing had worked. As his health deteriorated he was unable to live with his family as he needed to attend the hospital for weekly dialysis. The evening that I met him, he was trying to fundraise 1 million birr which is the equivalent of £25,000 to secure a kidney transplant. His story really opened my eyes and put into perspective how blessed we are in the UK to have the NHS. After meeting Addis I felt very fortunate for the health of my family and myself.
During the time I spent in Addis Ababa one of the other projects I worked on was capacity building for a charity called Redeem the Generation which focused on the potential of young people and women. I worked on developing and improving their facilities to ensure they were providing a good service for the local community. One of my biggest achievements during the project was organising ICT training programme for women which was attended by 15 women and several community elders.
The three months I spent in Addis Ababa were truly unforgettable: I learnt a new language, experienced a new culture and made life-long friends. What’s more I got the opportunity to make a tangible difference in the lives of others.
Since my trip I have become a real advocate for international development and female entrepreneurship. My experience has not only helped cement the importance of being a team player but also developed my leadership skills – which has really helped me here at Randox.”
We hope Charlie’s story has inspired you to grab new international opportunities that will help improve the wellbeing of others. Randox is committed to revolutionising healthcare through its diverse and multi-talented team.
Make sure to follow Randox Careers on Facebook, Twitter and Instagram to stay up-to-date with the hashtag #WeAreRandox
What is Six Sigma?
Six Sigma is a method of process improvement which focuses on minimizing variability in process outputs. The Six Sigma model was developed by Motorola in 1986, and Motorola have reportedly saved over $17 Billion due to its successful implementation.
The model looks at the number of standard deviations (SD) or ‘sigmas’ that fit within the quality specifications of the process. In the laboratory, the quality specifications relate to the Total Allowable Error (TEa). The higher the number of standard deviations that fit between these limits, the higher the sigma score and the more robust the process or method is. As sources of error or variation are removed from a process, the SD becomes smaller and therefore the number of deviations that can fit between the allowable limits is greater; ultimately resulting in a higher sigma score.
A process with a sigma score of six is considered to be a high quality process, making six the target for many industries including the clinical laboratory.
In order to achieve Six Sigma, a process must not produce more than 3.4 defects per million opportunities. In a Laboratory context, this would equate to 3.4 failed QC results per million QC runs.
Sigma is calculated using the following equation:
Sigma = (TEa – %Bias) / %CV
TEa – Total Allowable Error
%Bias – Deviation from the target or peer group mean
%CV – Imprecision of the data
Why is Six Sigma useful in the laboratory?
Six Sigma can be used to help answer one of the most commonly asked questions in laboratory quality control. How often should I run QC?
The Six Sigma model allows laboratories to evaluate the effectiveness of their current QC processes. Its most common use is to help implement a risk-based approach to QC, where an optimum QC frequency and multi-rule procedure can be based on the sigma score of the test in question. The performance of tests or methods with a high sigma score of six or more may be evaluated with one QC run (of each level) and a single 1:3s warning rule. On the other hand, tests or methods with a lower sigma score should be evaluated more frequently with multiple levels of QC and a multi-rule strategy designed to increase identification of errors and reduce false rejections.
The below table shows how multi-rules and QC frequency can be applied according to Sigma Metrics:
| Sigma Score | QC Frequency | Number of QC Samples | QC Rules |
| 6 or more | Once per day | Each level of QC | 1:3s |
| 5 | Once per day | Each level of QC | Multi-rule strategy |
| 4 | At least twice per day | Each level of QC | Multi-rule strategy |
| < 4 | At least four times per day | Each level of QC | Multi-rule strategy |
It is important to note that this is just an example and it may be necessary to run QC samples more often than three times per day. Some high throughput laboratories prefer to run QC samples before and after a set number of patient samples, while others opt to run QC samples after a set period of time. Whatever frequency you choose it is vital that the frequency is appropriate for the test in use. Download our guide ‘How often is right for QC’ to find out more.
What can Randox offer?
Randox’s Acusera 24.7 Live Online is a peer group reporting software application designed to complement the Acusera QC range. The intuitive and user-friendly software boasts some of the most advanced features on the market, and Version 1.6 provides automatic calculation of sigma scores for individual assays, giving the user an at-a-glance overview of assay performance.
Peer group reporting software is an integral part of any modern laboratory seeking to streamline their QC processes and reduce costs. With Acusera 24.7 Live Online, there has never been a better time to implement, save and succeed.
Contact us today to find out how Randox can help your laboratory achieve its goals.
Maintaining optimal brain health
Do you want to have optimal brain function later in life? We do. The majority of people focus on keeping their bodies in optimal condition but often forget about the most important organ, the brain. With more of us living until we’re much older, reduced brain function and Alzheimer’s are becoming increasingly more common; it is one of the most feared consequences of aging. We expect our bodies to age due to wear and tear; however there are easy ways to slow it, you will be glad to hear. Here are some top tips to keep your brain health at its peak.
- Get physical exercise
It is becoming an increasingly well-known fact by scientists that regular exercise may be the single most important thing you can do to ensure optimum brain health. The reason for this is that exercise increases the blood supply to your brain so therefore increases your brain capacity. Experts advise 30 minutes of exercise every other day to ensure good mental health. Exercise also helps with cholesterol levels, mental stress and diabetes.
- Eat, eat, eat
Good nutrition is also essential for good brain health. Your brain is no different to any other organ: the better the fuel it receives; the better it works, simple. As with everything it is important to keep your calories in check as it has been proven to reduce mental illness. We aim to reduce the consumption of saturated fats and cholesterol as these can decrease brain function. No matter who you are, vitamins are also very important to ensure not only a healthy brain, but a healthy body. Vitamins of particular importance are folic acid, B6 and B12 which it is well-known can help lower your homocysteine levels. There is an ever-growing body of research which suggests that homocysteine levels have a strong correlation with Alzheimer’s and dementia. If you would like to read more about the link between homocysteine and Alzheimer’s, check out our previous blog post ‘How important is homocysteine research for Alzheimer’s disease?’
- Get enough sleep
Recent studies have suggested that a poor sleeping pattern is linked with cognitive decline in old age. A good night’s rest can actually double the chances of finding creative solutions to problems faced in everyday life! It has been proven that when we don’t sleep, proteins build up on the brain. These proteins build on the synapses, making it hard to think and learn new information; which is not conducive to good brain health.
- De-stress
Relaxation is key in a healthy lifestyle. Stress has a negative impact on the brain. It creates harmful chemicals to flow over areas of the brain that are in control of memory. Too much of these chemicals can lead to dementia and other memory loss related diseases, so maybe it’s not such a bad idea that you take that trip to the Bahamas you were thinking about!
- Improve you cholesterol
Cholesterol is commonly split up into good cholesterol (HDL) and bad cholesterol (LDL). There are loads of ways to improve your cholesterol levels such as exercise, weight control, dieting and avoiding tobacco. It is very important to keep you levels of LDL down as high levels can increase the risk of Alzheimer’s, dementia and cardiac problems in old age. At Randox we are constantly coming up with new and exciting ways of monitoring your cholesterol and the launch of our new HDL3 test is coming soon. For more information on HDL3, check it out here!
- Brain exercises
Challenging your mind from time to time is important for good brain health; it keeps your brain active and uses cognitive thought to try and learn or solve a problem. It is thought that a lack of education is a strong influence in cognitive decline. Challenging your brain improves memory, develops critical thinking and stimulates the whole brain ensuring brain health is kept to a maximum. It can often be done in fun ways like brain teasers, puzzles and jigsaws. Check out our recent brain teaser here!
These are only some of the ways in which to keep your brain in peak condition. Aging will take a toll on everyone and it is impossible to avoid; however these 6 techniques can help maintain optimal brain function! We have been keeping up to date with Alzheimer’s in celebration of World Alzheimer’s Month. Remember a healthy brain is the key to success!
For health professionals
Randox Laboratories manufacture a wide range of routine and niche biochemistry reagents suitable for both research and clinical use. These include an automated homocysteine test and our new HDL3 cholesterol assay. Please contact reagents@randox.com for further information.
Randox and Chan Zuckerberg Initiative share common goal
You may have read in the news this week that the Chan Zuckerberg Initiative co-founded by Mark Zuckerberg has pledged to invest $3 billion over the next decade to help further and advance medical research. Investments will go towards a research facility, named the Biohub, which will focus on developing new tools to research, understand and treat diseases, and of particular interest to us here at Randox, on creating a chip to diagnose disease.
Here at Randox we fully support this drive to further research that is devoted to revolutionising healthcare. We commit up to 16% of turnover to research and development each year and currently over 20% of the world’s major laboratories are using Randox products.
In particular, we invested £220 million into the development of our Biochip Array Technology (BAT). The Randox biochip has revolutionised the diagnostics industry by facilitating the detection of a wide range of markers of disease from a single undivided sample. This not only enhances patient diagnosis but reduces the amount of time spent on individual tests and associated laboratory costs.
Our expertise, highly specialised scientists and world-class ISO accredited manufacturing facilities enables early, accurate, informed clinical decisions in the areas of veterinary testing, molecular research and diagnostics, drug development, food safety and forensic and clinical toxicology.
Our Randox Health clinics use our Biochip to allow people to avail of the complete portfolio of Randox routine and novel tests to empower their health decisions. This new and exciting service provides personalised and preventive health profiling for each individual.
Speaking about the biochip Dr. Peter FitzGerald, Founder and Managing Director of Randox said,
“Many years of development and the expertise of our highly qualified scientists have gone into the creation of Randox Biochip Array Technology. This scientific development will facilitate the simultaneous quantitative or qualitative detection of a wide range of analytes from a single undivided sample. This approach both proteomic and genomic enables an enhanced patient diagnosis, optimum efficiency and consolidation of cost. Our arrays are suitable for use in a wide range of settings including clinical and research laboratories, biopharmaceutical organisations, forensic and clinical toxicology, hospital laboratories, food testing and veterinary laboratories.”
We are delighted that Chan Zuckerberg’s interest in this area brings to the forefront the importance of improving healthcare through innovative diagnostics. It is clear that Randox and the Chan Zuckerberg Initiative share a common goal to revolutionise healthcare worldwide and we believe that the Randox Biochip can play an important role in realising this vision.
For further information please contact our Randox Comms Team on 028 9445 1016 or email amy.mcilwaine@randox.com
Liquid Controls vs Lyophilised Controls
Results of our Liquid vs Lyophilised Poll
Having conducted a recent poll on our Social Media platforms (Facebook, LinkedIn & Twitter) asking our customers what format they preferred their quality control material in – liquid or lyophilised – we saw a large preference for liquid controls.
What does this poll result really tell us?
That most people prefer Liquid controls? Yes.
Lyophilised controls are not as popular amongst our social following? Yes.
However, it also tells us that even though most people chose a liquid format there was still almost a quarter of people who prefer to use lyophilised controls. Liquid and lyophilised controls both have their advantages and disadvantages, this blog is designed to help you decide which is the best fit for your lab.
Liquid Controls
Firstly, it is important to note that there are two distinct types of liquid control available on the market;Liquid ready-to-use and Liquid for ease-of-use, better known as Liquid Frozen. Both types of liquid controls reduce the potential for reconstitution errors and prevent contamination from poor quality water.
Liquid frozen controls must be thawed in a refrigerator before use, making them a little less convenient than the liquid ready-to-use alternative. They require no reconstitution so associated errors are removed. Due to the frozen nature of these controls, they are often shipped on dry ice to prevent thawing in transit, as such transportation costs can be significant.
Liquid ready-to-use controls are arguably the most favoured of the three formats and it is easy to understand why. The controls are simple to use, they require no preparation and there is no need to thaw before use.– With zero preparation required, these controls can be removed from the packaging and used right away! What’s more, they can be conveniently stored at 2-8oC minimising expensive shipping costs.
Another major benefit of using a liquid ready-to-use control is the fact that they are ideal for POCT (Point of Care Testing). The ability to use these controls on the spot is extremely beneficial to POC providers.
Lyophilised Controls
Lastly, the choice of 22% of respondents – lyophilised. This is freeze dried material which requires the laboratory professional to reconstitute the sample using sterilised water and mixing before use. Although this format is not as easy to use as either liquid control it does come with benefits. The enhanced stability of this control sees a shelf life of almost double the two years that is normal with a liquid control, however, the potential for reconstitution errors and the fact it is not as simple to use lead to the majority of people opting for a more convenient liquid control.
Randox Quality Control Range
With Randox QC there are a vast array of controls available in liquid ready-to-use and liquid frozen formats. Areas we have liquid frozen formats available in, include; Clinical Chemistry and Immunoassay.
Liquid ready-to-use controls can be found in the following; Liquid Cardiac, Blood Gas, Liquid Urine, Urinalysis, Specific Protein, Ammonia Ethanol, Haematology, Liquid HbA1c and Liquid Tumour Markers.
Lyophilised controls available with Randox QC can be found within; Chemistry, Immunoassay, Cardiac, Coagulation, HbA1c, Lipids and Therapeutic Drug Monitoring.
To register an interest in any of our controls simply contact us at acusera@Randox.com and let us know how we can help and support you or alternatively click here – where you will be redirected to our contact page.
ISO 22870:2006 in the Point-of-Care Testing (POCT) Market
Point-of-Care Testing (POCT)
The Point-of-Care testing market, better known as POCT, is growing rapidly as the demand for faster patient testing increases. This point is fully backed up through the results of the recent BIVDA (British IN-Vitro Diagnostics Association) survey of 2016. This survey focuses primarily on Point-of-Care Testing and there were a few questions asked that sparked an interest amongst us. The questions can be seen below;
“What are the challenges you face regarding POCT?”
“What do you see in the future for POCT?” (BIVDA, 2016)
Although many answers were put forward there was one (answer) that appeared for both questions. Accreditation. We found this intriguing yet far from surprising. POCT and accreditation go hand-in-hand, with laboratories striving to achieve ISO accreditation with the ultimate aim of allowing patients to have peace of mind that they are being tested properly and effectively.
ISO 22870:2006
The ISO standard that relates to POCT is ISO 22870:2006 Point of Care Testing- Requirements for quality and competence. This standard gives specific requirements applicable to POCT testing and apply when POCT is carried out in a hospital, clinic or a healthcare organisation providing ambulatory care. However, it is important to note and remember that ISO 22870 is not to be seen as a separate, standalone document, in fact, it is to be used in conjunction with ISO 15189:2012 (medical laboratories – particular requirements for quality & competence).
With accreditation in POCT becoming a major factor to laboratories, it is no surprise to see accreditation as one of the top answers to the two questions asked in the survey.
For laboratories looking to participate in point-of-care testing there are other factors of ISO 22870 that they must be aware of, one of the major factors is as follows;
“ISO 22870:2006 advises that where available, Internal Quality Control and participation in an External Quality Assessment (EQA) scheme is required in the point-of-care setting.”
How can Randox help?
Fortunately for laboratories, Randox are able to help out here. With a vast range of true third party controls and 32 comprehensive RIQAS (EQA) programmes, Randox can aid laboratories as they aim for ISO accreditation.
We have multiple products particularly suited to the POCT market including, Liquid Cardiac, Blood Gas and Urinalysis. These products are available both as internal quality controls and as EQA programmes.
Our Acusera range of true third party controls are conveniently supplied liquid ready-to-use, therefore requiring no preparation. This is a particular advantage in the POC environment were test results are required quickly and also were testing is not always performed by laboratory personnel. Supplied with assayed target values and manufactured from 100% human material, ensuring they act in the same manner as a patient sample, our Acusera controls are ideal for use at the point of care and will therefore aid a laboratory in gaining ISO accreditation.
Similarly, participation in our RIQAS EQA programme will also assist laboratories to meet regulatory requirements and achieve ISO accreditation. With over 40,000 laboratory participants in 123 countries, RIQAS is the largest international EQA scheme worldwide! Our Liquid Cardiac, Blood Gas and Urinalysis programmes are all supplied liquid ready-to-use, complementing their Acusera counterparts perfectly!
By using our Acusera controls and RIQAS EQA programmes side by side, a laboratory can confidently aim for ISO accreditation in the knowledge that they are meeting criteria.
Randox Reagents: Solving the Problem of Heart Attack Misdiagnosis
A report has today revealed that almost a third of patients in England and Wales are being given a misdiagnosis following a heart attack, following a study of 243 NHS hospitals, conducted by researchers at Leeds University.
Timely evaluation of patients with chest pain and subsequently suspected heart attack is a major challenge for hospitals around the world, with chest pain typically representing around 5% of all visits to the Emergency Department (ED) and 25% of ED admissions. One of the biggest challenges facing emergency doctors now is how to prioritise people presenting with chest pain – to primarily deal with those suffering from a heart attack, and to be able to move those who are not, to a different ward, to alleviate the pressures of the overrun A&E departments.
Responding to the escalating misdiagnosis crisis in emergency hospitals across the globe, scientists at Randox Laboratories in the UK have developed a test which could help clinicians rule out heart attacks in patients immediately upon arrival at hospital; allowing clinicians to accurately prioritise those who have truly suffered heart attacks.
This Randox test, for Heart-type fatty acid-binding protein (H-FABP), is a highly sensitive biomarker for use in the earlier diagnosis of patients with suspected Acute Myocardial Infarction (AMI), enabling faster “rule-in” and “rule-out”. H-FABP is detectable as early as 30 minutes after chest pain onset, significantly earlier than traditionally used biomarkers such as Troponin or CK-MB , which typically require 6-12 hours to reach detectable concentrations.
Put simply, given that H-FABP is released earlier than traditional biomarkers used in diagnosing a heart attack, an earlier diagnosis is achievable.
A succession of recent international clinical trials have demonstrated that by combining H-FABP, via this new laboratory assay, with the existing tests already used in hospitals for for Troponin I or Troponin T, the sensitivity and negative predictive value for ruling out AMIs is significantly improved.
Growing evidence indicates that even when one of the newer generation of “highly sensitive” Troponin assays is used, utilising the combination of Troponin and H-FABP is superior to Troponin alone.
The value of H-FABP is not just in positive diagnosis – but doctors are beginning to see it as a means of ‘ruling out heart attack’ when a patient presents at A&E with chest pain.
Please do get in touch if you would like to find out more about our H-FABP test, and how this can go a long way in solving the heart attack misdiagnosis crisis, by emailing reagents@randox.com
How frequently should you run EQA?
There is much debate among clinical laboratories when discussing this common question. With some schemes offering testing as little as 2 times per year, it raises the question, is this really enough?
How frequently an EQA scheme is run will often be dependent on several aspects. Factors such as the diagnostic error rate, number of tests undertaken, experience and turnover of technical staff, and the known stability/instability of the analyte in question should be considered and will all contribute to determine the desired frequency of EQA.
Each EQA programme will vary, where one area, for instance Chemistry, may require bi-weekly testing, another, such as Serology, may only need to be tested every 3 months. Although there is variation between schemes, the benefits of testing more frequently unquestionably outweighs the costs of not testing frequently enough.
Issues with infrequent testing?
If your EQA provider offers infrequent testing, there is likely to be a lengthy period of uncertainty where errors could be happening in the laboratory and consequently incorrect results being released. The outcome of this could be damaging to both patients and laboratories, with credibility and trust in results likely to come under scrutiny. For these reasons, having an infrequent EQA scheme could cause harm to your laboratory and reduce confidence in your test results.
Why should you use a frequent EQA scheme?
To ensure the previously mentioned errors do not occur, laboratories should participate in frequent EQA schemes to guarantee that if incorrect test results do arise, then they will be detected and rectified immediately.
As preventative/corrective actions can be taken sooner through frequent EQA schemes, you will have increased confidence in your test systems performance and may reduce the need for expensive retests. Being able to pinpoint when an error occurred will be much simpler if you are only looking back a matter of weeks or a couple months, as opposed to if you are looking back over a longer period such as 4 to 6 months.
The ability to implement corrective actions sooner and with less disruptions to the lab will help lead to both time and cost savings in the future.
What can Randox Quality Control offer?
Randox International Quality Assessment Scheme (RIQAS), offers bi-weekly, monthly and quarterly reporting options* designed to assist with the early identification of laboratory errors. Not only will RIQAS provide you with extra confidence in test system accuracy, but with 32 flexible programmes you could also make significant cost and time savings through consolidation.
With more than 40,000 participants in 124 countries, RIQAS is the largest international EQA scheme on the market and offers laboratories around the world assurances that the results they are releasing are accurate and reliable. Our many features include; the ability to register up to 5 instruments per programme at no extra cost, easy to read reports, internationally accredited programmes and rapid report turnaround. Why don’t you contact us today and find out how we can support you in maintaining quality control in your laboratory?
*Programme Specific
We Are Randox | Randox Rugby Team Promote Healthy Work-Life Balance at Randox
As a global healthcare diagnostics company, we know a thing or two about health. And we know that taking time out from our busy lives to relax and unwind is important to stay healthy. Whether that’s taking your dog for a walk, meeting up with friends, getting lost in a good book, or playing your favourite sport.
Playing a competitive sport brings a wealth of benefits – it’s the perfect way to socialise and look after your health at the same time! Not only is it good for your physical health, but can go a long way in maintaining your mental wellbeing too.
There is great value in exercise and fresh air. However, it’s an unfortunate fact of life that most 9-5ers just don’t have the opportunity to indulge in this pleasure very often.
Randox, being a company serious about health and wellbeing, like to know we’re giving our employees the best opportunities to be as healthy as they can, and live their lives as fulfilled as possible.
Amongst many sports in which Randox encourages employees to take part, we encourage our employees to regularly take the time to engage in some friendly competition of 5-a-side rugby against each other. The County Antrim countryside, in which our Randox headquarters are located, is the perfect setting for an informal game of rugby – our rugby players can let off some steam and take in the scenery at the same time!
The team was banded together by Randox Founder and Managing Director, Dr. Peter FitzGerald, who occasionally joins in on the games himself! Dr. FitzGerald is a strong advocate of teamwork and camaraderie in the workplace.
Jonathan Acheson, Randox Health Sales Executive, who plays for our Randox Rugby Team, commented;
“At Randox we work hard but we play hard too! Our work can often be very fast-paced and Randox is expanding phenomenally – for example we’re all working towards our 5 year sponsorship of the Randox Health Grand National, beginning in 2017, which is keeping us all very busy. So it’s important that we take time to unwind and recharge our batteries. We’re lucky that we’re able to take advantage of being in such a lovely area of Northern Ireland – right beside Lough Neagh – and so we can get outside after work and have a good run-about!”
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