Careers Tips | Don’t Get Stressed… Deskercise!
Careers Tips | Don’t Get Stressed… Deskercise!
Ever wonder how motivated and successful people stay so calm at work? Here at Randox, we know that even the most enjoyable careers can get stressful, even for the most motivated employees!
According to a CIPD Absence Management Survey the number one cause for long term sickness is stress. When the paperwork begins to pile up and to-do lists become longer it can be difficult not to let the mounting pressure get to you. But, there’s good news! Exercise is not only for the body, but the mind too. Exercise at work can improve our mental wellbeing improving our ability to deal with the pressure/stress in our working lives. So, if you want to keep your cool like John from H.R., here’s some tips on how you can make some changes today towards improving your mood (even on Mondays!)
1. Get up a go. We all realise how important exercise is but making the time for it in our busy lives can be difficult. Why not make simple changes increasing the amount of physical activity you can squeeze into your day. Take the stairs whenever you can. Perhaps even park your car in a space further away meaning more time to stretch your legs.
2. Stretch at your desk. Research by the NHS says Adults in the UK are sitting for 7 hours a day! Find yourself staring at your computer screen all day? Alternate your tasks at works. Why not even try the CIPD suggested “chairobics”…stretches you can do without even leaving your chair such as rotating your shoulders. Chairobics is so widely praised there’s even sit-down aerobics classes based on teaching people how to get moving at their desk!
3. Clear your head. Don’t be afraid to take a screen-break every now and again. I know it can seem like you’re wasting your precious work time, but clearing your head of the stresses you accumulate at work will give you a clearer perspective on things ensuring you remain motivated and more productive. There is a long history of research into breaks and the correct amount of time for a computer-break. Employers first began offering the break because of its effects of revival on work quality. Not only does it revive your work, however, it revives you! Physical activity goes a long way contributing to improving your own mental well being. Any activity that makes you feel good does well. Feeling good boosts your productivity in work and as the saying goes “Nothing will work unless you do”.
4. Sit up straight. Good posture at your desk will improve your breathing making you feel calmer and therefore less like likely to get stressed no matter what work related task is thrown your way. Bad posture, on the other hand can cause many problems such as pains, and headaches. Try this. Roll your shoulders back and straighten your spine. Lift you chin up. How much better do you feel? More motivated and ready to take on the world of work? Don’t question the power of good posture on your mood!
In conclusion, we quote Ziggy Marley; “Doing something that is productive is a great way to alleviate emotional stress. Get your mind doing something that is productive.” We all want to be as cool as a cucumber in stressful situations at work so the next time you’re feeling under pressure try some of these tips and smile! It’s Friday, afterall!
For more tips, follow Randox Careers on Facebook, Twitter and Instagram. Take a look at our website to discover the endless job opportunities open to you!
Demand for external support driving growth of EQA
“In Vitro Diagnostics (IVD) Quality Controls Market” recently published by Markets and Markets has highlighted an overall significant growth within the Quality Control Market. Further growth is anticipated in the coming years with the Markets and Markets report estimating that the IVD QC market will be worth $979 million.
One area that is currently experiencing growth within this sector is the EQA segment, which Markets and Markets estimates to command a 6.6% share of the overall IVD market. The report is crediting growth within this segment to you, the customer, stating “…various end users or customers of IVD quality control products mostly prefer external support to run their quality control activities. For this, market players are largely focusing on providing external quality assurance (EQA) support”. As such companies such as Randox are being approached to provide EQA for a range of small, independent laboratories and large laboratory chains alike.
What other factors have contributed to this growth?
The adoption of ISO15189 and other similar standards is becoming mandatory in many countries, as discussed in a previous blog post. Accreditation highlights the accuracy and reliability of the patient results being released. ISO15189 states that “The laboratory shall participate in interlaboratory comparisons such as those organised by external quality assessment or proficiency testing schemes”. Therefore laboratory managers are employing EQA programmes in their laboratory to meet such requirements. EQA also enables laboratories to meet other accreditation requirements such as peer comparison and clinically relevant testing.
Selecting the right EQA for you
When selecting the right EQA scheme for your laboratory there are a number of considerations to be made; sample frequency, peer group numbers, report format, report turnaround and so on. According to a survey conducted by Randox Quality Control 55% of respondents listed sample frequency as the most important feature to be considered when selecting an EQA scheme. Sample frequency is an ongoing debate regarding EQA. However, schemes with frequent reporting will allow you to easily pinpoint when an error occurred and implement corrective actions with minimal disruption. Also making the top three key factors in this survey were; quality samples and peer group numbers.
What can Randox Quality Control offer?
As the largest international EQA scheme available on the market RIQAS offers laboratories around the world assurance that the results they are releasing are accurate and reliable. With more than 40,000 participant in 124 countries and 32 flexible programmes we are certain that the external support we offer for your quality control activities will provide you with the upmost confidence in your laboratory’s performance. Furthermore with our programmes accepted by national and international accreditation bodies worldwide employing RIQAS can help you gain accredited status providing your end users with peace of mind. With other benefits such as programme consolidation, rapid report turnaround, easy to read at-a-glance reporting and the ability to register up to 5 instruments per programme at no extra cost why don’t you contact us today and find out how we can support your quality control activity?
To request a visit from a QC consultant contact us via acusera@randox.com
What is Visceral Fat?
Visceral fat (or abdominal fat) is body fat which is stored within the abdominal cavity. It wraps around your vital organs including the liver, pancreas and intestines, and as a result can have a negative impact on your health. In fact, visceral fat has been linked to increased risk of health problems such as type 2 diabetes, heart disease and some cancers.
It is important to distinguish the difference between subcutaneous fat and visceral fat…
Subcutaneous fat is the fat we store under our skin. It is the tissue that we can feel when we pinch ourselves, and contains blood vessels in addition to fatty tissues. Visceral fat, on the other hand, cannot be felt in such a way as it is the extra fat stored around our organs. It is the most dangerous type of fat as it much harder to identify.
No matter what your shape or size, you may be carrying excess visceral fat!
Regardless of shape or size an individual can be carrying excess visceral fat. This means that whether your doctor tells you that you’re underweight, overweight, obese or of a healthy weight, you may be carrying excess visceral fat within your abdominal cavity.
That is why BMI is an inaccurate measurement of health…
Body Mass Index (BMI) is used by many as an indicator of health. It involves comparing your weight in relation to your height to give an indication of your weight status i.e. whether you are categorised as underweight, overweight, healthy or obese. It doesn’t take into account muscle mass, age, sex, ethnicity, general level of fitness or visceral fat. Therefore, even if you have a ‘healthy’ BMI you may still be carrying excessive visceral fat, and could still be at risk of the health complications associated with it.
As a result, relying on BMI could put you at risk of countless diseases…
Visceral fat is often referred to as ‘active fat’ due to the effect it has on our hormones and body functions. It can interrupt normal hormone communications between your vital organs, and can lead to insulin resistance and eventually type 2 diabetes. Additionally, it can affect the functions of your organs and puts you at higher risk of developing heart disease or cancers including breast cancer or colorectal cancer.
So, what can you do to protect yourself?
Factors which contribute to visceral fat levels include stress, diet and exercise habits in addition to age, ethnicity and gender. Living a healthy lifestyle will therefore reduce your chances of visceral fat accumulating in your abdominal cavity.
If you are worried about your visceral fat levels the waist-to-hip ratio (found by dividing waist width by hip width) can give an indication of total fat as well as the level of visceral fat, however the most accurate measurement of visceral fat is to measure adiponectin levels in the blood.
Adiponectin (a blood analyte) is closely linked with visceral fat; low levels of adiponectin indicate high levels of visceral fat. The Adiponectin test enables true measurement of visceral fat levels and allows for more accurate measurement of health than traditional BMI; if you have been diagnosed with unhealthy BMI and believe this to be an inaccurate diagnosis, testing your adiponectin levels can help determine your true measurement of health. Simply ask your doctor for the Adiponectin test!
Further reading:
For health professionals:
The adiponectin test from Randox can accurately assess levels of abdominal visceral fat, independent of age, race or fitness level. Assessing adiponectin, and therefore visceral fat levels, can help assess risk of CKD, as well as a range of other illnesses such as pre-diabetes, CVD and various cancers. Contact us now for further information.
The Secrets of the Aging Process
Age is associated with increases in body weight, body fat, abdominal fat, deterioration of muscles, and arthritis. However, everything in the body happens at the cellular level. Outward signs of aging that you may see, such as wrinkles and grey hair, are only symptoms of what is happening on a microscopic scale.
A study carried out by Raul A Martins, using the RX imola, outlined an experiment, investigating how we can affect our own inner-biological make-up, on a much deeper scale than muscle build-up, through exercise and activity:
“To investigate the training effect of sixteen weeks of moderate intensity, progressive aerobic and strength-based training on metabolic health of old women and men. Sixty three sedentary individuals were randomly assigned to control or exercising groups. The training group was separated to aerobic or strength-based. Training took place 3 times a week. Subjects agreed not to change their diet or lifestyle over the experimental period. Exercising group attained after treatment significant differences on body weight, waist circumference, body mass index, diastolic blood pressure, triglycerides, total cholesterol, HDL cholesterol, LDL-cholesterol, total cholesterol/HDL-cholesterol relationship, high sensitivity C-reaction protein and 6 minute walk distance. The control group only had significant differences on waist circumference” wrote R.A. Martins and colleagues, university of Coimbra.”
As shown in the experiment, exercising does not only affect our muscle mass and body fat index. It does, in fact, affect us on a cellular level.
Before outward aging symptoms are expressed, your cells, your DNA, and everything that makes up you is reacting to your lifestyle and responding appropriately. A particularly lifestyle-sensitive part of your DNA associated with aging are telomeres.
Telomeres are caps at the ends of DNA strands, made up of a combination of DNA and protein. They protect the ends of the chromosome and keep them stable. Telomeres, however, are incredibly sensitive and have a tendency to become damaged and unravel, prompting a process called “telomere shortening”. Telomeres are associated with the changing nature of our bodies, and therefore, are classed as important aging biomarkers – with their length indicating lifespan. Each time our cells divide, our telomeres shorten. After many dozens of years of cell division, these biomarkers have reached a point where they can longer become any shorter. At this point, cell division discontinues and this is where aging will occur, as cells begin to die faster than they are created. Our body begins to break down. Effects such as hair falling out and skin sagging, are all symptoms of telomere damage or shortening. Telomere shortening has not only been associated with aging, but also age-related diseases such as Parkinson’s disease, Alzheimers, cardiovascular disease, Diabetes, and some forms of cancer.
There is good news, Martins noted in his experiment that exercise appears to keep telomeres from unravelling, shortening and becoming damaged, and therefore, can be classed as a natural anti-aging activity.
Through examining white blood cells, scientists can monitor telomere shortening (and damaging) whilst monitoring exercise and lifestyle of subjects. Another group of scientists in Germany conducted a similar experiment, gathering women and men of different ages to examine their lifespans relative to exercising, they noted:
The sedentary older subjects had telomeres that were on average 40 percent shorter than in the sedentary young subjects, suggesting that the older subjects’ cells were, like them, aging. The runners, on the other hand, had remarkably youthful telomeres, a bit shorter than those in the young runners, but only by about 10 percent. In general, telomere loss was reduced by approximately 75 percent in the aging runners. Or, to put it more succinctly, exercise, Dr. Werner says, ‘‘at the molecular level has an anti-aging effect.’’
(Gretchen Reynolds, 2010)
So, to put a number on it, studies show, exercise can reduce the aging process by up to a whopping 75%.
As well as it’s anti-aging properties, there are a surplus of other benefits of exercising, such as increased release of endorphins and relieving of muscular pain. Currently, there’s a good deal of research being conducted into potential drug based approaches for telomere shortening, yet these drugs are still years away. So, for now, exercise and healthy eating is the only known way to stave off aging… As if we needed another healthy reason to get active!
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Read more about the experiment conducted on the RX imola:
Microalbumin shifts when changing reagent batch
A laboratory running a competitors 3rd party Microalbumin QC noticed shifts in their QC values whenever they changed reagent batch.
They tested two levels of quality control over three different batches of reagent the results can be seen in the table below.
| Competitor Control – Microalbumin | ||
| Reagent Batch |
QC Level One |
QC Level Two |
| 1 | 19.9 | 81.0 |
| 2 | 29.7 | 90.5 |
| 3 | 50.4 | 122.4 |
As can be seen from the findings above, Microalbumin results shifted significantly each time they changed reagent batch. This was the case for both the level one and level two control however when the lab tested the same set of patient samples across the three reagent batches results were consistent and did not show the same shifts.
The laboratory decided to contact Randox and ask about our Microalbumin controls. They were concerned about the shifts seen with their current supplier and highlighted the fact they were no longer confident in the results they were releasing. This led to them trialling the Randox liquid ready-to-use Microalbumin control with the same three reagent batches they tested previously.
Having tested two levels of the Randox quality control over the same three reagent batches the laboratory reported to us that their results were back on track and they were delighted with the outcome! The results of the Randox control can be seen in the table below.
| Randox Control – Microalbumin | ||
| Reagent Batch |
QC Level One |
QC Level Two |
| 1 | 33.5 | 158.8 |
| 2 | 34.9 | 164.9 |
| 3 | 34.8 | 168.0 |
The difference seen with the Randox control across the three reagent batches was much smaller than that of their previous control and was in line with the changes seen with their patient samples.
This case study highlights the commutability of the Randox QC range. By using a control with a matrix that reacts to the test system in the same manner as the patient sample the laboratory was confident in the patient test results produced and were able to meet ISO 15189:2012 requirements.
Serving Up Accurate Test Results
Today, June 27th, sees the beginning of one of the four tennis majors – Wimbledon. Basking in the summer sun while lying on ‘Henman Hill’, this yearly tournament attracts spectators from all over the globe who want to watch the world’s best tennis players ply their skills on the revered centre court over the course of a two week period. But what exactly is the most important skill a tennis player can utilise? Well, many players have different strengths but the one skill that all of them must possess is the ability to serve – and accurately.
The ability to serve is vitally important as it allows the point to begin, serving accurately however allows the player to set the pace and ensure they are on the front foot. By making sure they serve more accurately, the player can be confident in their ability to win the point and the match.
Just like tennis, laboratories will aim to be accurate when ‘serving’ up their test results. Achieving accurate test results is what every lab strives for. With patient results on the line it is important for labs to use QC material that will assist them in obtaining the correct results, therefore keeping them clear of causing a ‘racquet’.
Randox Acusera is world renowned for delivering unbiased performance assessment. Our range of true third party controls are manufactured to the highest standard ensuring commutable samples that react to the test system in the same manner as a patient sample, ultimately allowing labs to be confident in the results they produce. Much like the serve in tennis that needs to fall within a target area, QC results should be as close as possible to the target and ideally should fall within +/- 2 SD from the mean. By falling within these limits a lab can be sure of accurate results and an acceptable performance.
Employ Acusera quality controls in your laboratory today and experience unrivaled confidence in your test results.
Get your slice of our control range here by contacting us at acusera@randox.com. We guarantee you will love us!
Randox celebrates women in engineering
Thurs 23rd June 2016 marks National Women in Engineering Day, an annual campaign that aims to highlight the role of women in engineering, and focus attention on the array of career opportunities available for women in this rewarding industry. The campaign is run by the Women’s Engineering Society (WES) whose goal is to ‘encourage women to participate and achieve as engineers, scientists and as leaders’. As a company who aim to inspire, and actively encourage women to enter careers in the areas of Science, Technology, Engineering and Maths (STEM), this resonates with us.
To show our appreciation of this campaign, we interviewed Randox Engineer, Maryrose McLoone from our Randox Teoranta team. Maryrose shared with us her journey into the industry of engineering…
How long have you worked in engineering?
I began working in Randox Teoranta after completing my undergraduate studies in Mechanical Engineering, and have been working here for the past year. Prior to this, as part of my undergraduate studies, I took a five month work placement as a Quality Intern at a medical device company.
How did you know a career in engineering was for you?
I have always been interested in maths and science, and the general STEM subjects. Engineering had been suggested to me by our Career Guidance Counsellor in secondary school due to my interest in maths. I hadn’t much experience with engineering related subjects prior to starting college but my undergraduate studies began with the basics, so everybody started on the same level.
How did you decide which area of engineering you wanted to pursue?
I chose Mechanical Engineering as it is a versatile form of engineering that would allow me to work in both the mechanical and biomedical engineering industries. My interest in working with medical devices came about during my college work placement. Through my placement I gained a great appreciation of engineering and the benefits it can have in the medical device industry.
Tell us about your role within the Randox Engineering team?
I work as a Mechanical Design Engineer. This involves designing and testing components and modules for clinical chemistry analysers. At the minute I am working alongside other Engineers from mechanical, electrical, and embedded systems, as well as Software Developers in the development of the RX misano test jigs which will be used for troubleshooting and to aid in QC procedures.
What skills have you gained with your career experience?
My role as a Design Engineer has allowed me to improve my skills in many areas such as design and testing, communication, organisation and time management skills, as well as gaining an understanding of the relevant medical device quality standards. My position involves working with a team of engineers from various engineering backgrounds, as well as working closely with quality and manufacturing to ensure the smooth transition from prototype to production.
What do you enjoy most about your job?
As a Design Engineer you are constantly coming up with new and creative solutions to problems. You can see your designs evolve from prototypes to completed projects. I find working in medical devices in particular to be a very fulfilling and highly rewarding job. You can be assured that your hard work is for a good purpose as it results in the creation of analysers which are used to conduct a wide variety of tests and perform important diagnoses. The design of clinical chemistry analysers involves careful consideration and attention to detail, an aspect which I enjoy.
My skills in the structure and organisation of tasks have developed from working in a highly regulated environment; such traits are extremely important when designing medical devices to ensure the production of quality products. As a Design Engineer working for Randox it is rewarding to be part of team that work together to improve healthcare through the development of clinical diagnostic solutions.
Do you work alongside any other women in the engineering department?
Yes, our R&D team comprises of Engineers in the areas of Mechanical, Electrical, and Embedded systems Engineering as well as Software Developers and Scientists. In our team there are women working in Embedded Systems, Software, and Science. Each team member has an important role in the design, development, and testing of our analysers. Embedded Systems Engineers and Software Developers work on developing and testing the software for our analysers. We also have a Scientist in our team who ensures our analysers can accurately run chemistry and helps in the verification and validation processes.
Proud to work as part of such a united team, Maryrose gives great insight into the role of a Design Engineer, and really highlights the depth of roles within the engineering industry; from System Engineers to Mechanical and Electrical Engineers. It is clear that women play a pivotal role in the Randox Engineering team, working together to design, develop and test our clinical diagnostic solutions.
Maryrose discussed her work as a Design Engineer within the RX series Engineering team. Her work on the RX misano has been crucial in the development of this new semi-automated analyser, details for which can be found below:
The RX misano is the newest analyser in the RX series of clinical chemistry analysers, and will be available for purchase soon. It is a semi-automated analyser designed with usability in mind; the screen has been positioned at an optimal viewing angle for the user, a touch button has been incorporated into the design to allow for the easy aspiration of sample, and, a 7” touch screen has also made the RX misano more user friendly than previous designs. The analyser software, developed by Randox, provides easy-to-use test screens and highlights any analytical problems to the user.
For more information, and to register your interest in the RX misano, please visit: therxseries.com/rx-altona
The RX misano is currently unavailable to purchase in Germany
MYTH: Only overweight people get type 2 diabetes, right?
The answer to this common myth is no. Let us tell you why…
As a condition that usually manifests later in life, type 2 diabetes is viewed by many as a self-inflicted disease caused by eating too much sugar and being overweight. Although obesity is strongly associated with type 2 diabetes it isn’t the only cause. In fact, many people of a healthy weight have type 2 diabetes, and similarly many overweight people do not. This is because an individual’s metabolic health can be affected by factors other than their weight.
Firstly, let’s define metabolic health; metabolic health refers to the body’s health at a cellular function, and one aspect of this is the body’s ability to utilise nutrients for energy. Within this insulin has an important function; insulin is a hormone produced by the pancreas and used by the body to regulate how glucose is used and stored. In some individuals, however, this is not the case; their pancreas may either not produce enough insulin, or may not be able to effectively use the insulin it produces, known as insulin sensitivity. High blood sugar level and type 2 diabetes is the effect of this.
Whilst obesity and lack of exercise are 2 of the most common reasons affecting metabolic state and causing type 2 diabetes, it is important to note that approximately 1 in 3 type 2 diabetics are undiagnosed. Therefore the causal factors of these individuals are not included in the statistics and therefore not accounted for in this statement. Other causal factors include family history, ethnicity, age, stress, inflammation, poor diet and visceral fat.
Let’s talk about a few of these factors…
Family history & ethnicity – Do genetics play a role?
Risk factors of type 2 diabetes includes family history and ethnicity; research(1) has found that there is a 1 in 7 risk of type 2 diabetes for children whose parents were diagnosed before the age of 50, and 1 in 2 risk for children if both parents have type 2 diabetes. Furthermore, research(2) has linked genetic mutation of the HMGA1 gene to an increased risk of type 2 diabetes in white Europeans; the study found that defects in the HMGA1 gene led to a drop in the body’s ability to make insulin receptors, thus leading to insulin resistance. In fact, 1 in 10 study participants with type 2 diabetes had a genetic mutation of the gene. Furthermore certain ethnic groups have been linked to increased risk of type 2 diabetes i.e. African Americans, Native Americans, Hispanic Americans and Asian Americans; some believe this may be due to genetics.
Chronic Stress
When the body is under stress, stress hormones such as cortisol are released. These hormones can affect the body’s blood glucose levels; for example, one of the primary functions of cortisol is to provide an immediate source of energy for the body, resulting in an increase of glucose supply to the blood. Individuals suffering chronic stress therefore have a constant production of cortisol, and chronically increased blood glucose levels as a result. This increases the risk of type 2 diabetes.
Chronic stress can lead to inflammation, which is another risk factor in the development of type 2 diabetes.
Inflammation
As the body’s natural response to injury, inflammation is the initial step in the healing process. Opening the blood vessels to allow free movement of the body’s natural healing substances to the affected site, it offers the body protection and fights off foreign substances such as germs and toxins. Inflammation is necessary to rid infections and heal wounds, however if the body suffers a chronic state of inflammation it can have damaging effects; chronic inflammation is caused by autoimmune conditions, allergies, chronic stress and conditions such as Crohn’s disease, and is linked to major diseases such as heart disease, arthritis and certain cancers. The link with type 2 diabetes is a result of inflammation causing insulin resistance, increasing the risk of type 2 diabetes.
Abdominal visceral fat
Abdominal visceral fat is the fat which surrounds the internal organs in the abdominal cavity. High levels of abdominal visceral fat are associated with insulin resistance and therefore, high risk of diabetes. Abdominal visceral fat can be found in individuals of all shapes and sizes, and regardless of ‘healthy’ BMI high visceral fat levels can still occur. This is because BMI doesn’t take into account muscle mass or other factors including gender and ethnicity. This presents an issue as those with a ‘healthy’ BMI may unknowingly still be at risk of diabetes. Similarly those with high muscle mass, who are determined ‘overweight’ based on BMI, may worry that they are at risk of diabetes, when in fact their weight isn’t putting them at risk. Determining levels of abdominal visceral fat is a much better indication of health than BMI.
Overall risk of type 2 diabetes is correlated with genetic, environmental and lifestyle factors. Whilst some impact more than others, it is important to recognise that there are numerous factors related to type 2 diabetes, and rid the myth that obesity and a high sugar diet high are the only causal factors.
Help set the record straight by sharing this article:
References:
(1) American Diabetes Association (2014) Genetics of Diabetes. Found online at diabetes.org/diabetes-basics/genetics-of-diabetes.html
(2) Brunetti et al (2011) Functional Variants of the HMGA1 Gene and Type 2 Diabetes Mellitus. Journal of the American Medical Association (JAMA); 305 (9):903-912.
If you are worried about your blood glucose levels, or risk of diabetes, ask your doctor for these tests:
- Glucose, HbA1c and Fructosamine to assess your blood glucose levels
- CRP to determine chronic inflammation with additional testing of SPLA2-IIA levels to determine vascular inflammation
- Adiponectin to assess your level of abdominal visceral fat. High levels of abdominal visceral fat can indicate metabolic syndrome and pre-diabetes.
For more information on diabetes testing visit our dedicated diabetes reagents page.
For health professionals:
Adiponectin is a protein which regulates the metabolism of lipids and glucose and influences the body’s response to insulin. Low levels of Adiponectin are correlated with increased CRP (increased inflammation), higher levels of triglycerides and insulin resistance. As a result of increased insulin resistance and inflammation, low levels of Adiponectin can indicate metabolic syndrome.
For more information please visit our dedicated Adiponectin page or view our full range of diabetes tests.
SPLA2-IIA is a highly specific marker of atherosclerotic plaque inflammation, and has a direct role in the formation of rupture-prone atherosclerotic plaque. Increased concentrations of SPLA2-IIA have been linked with increased risk of cardiocerebrovascular events. As a highly specific marker of vascular inflammation, it complements tests such as hsCRP, and can be used to improve the risk assessment of patients with moderate to high risk of CVD, in particular those with metabolic syndrome such as insulin resistance.
Further reading: Sertić et al (2010) Does Lp-PLA2 determination help predict atherosclerosis and cardiocerebrovascular disease? Acta Med Croatica. 64(4):237-45
Randox SPLA2-IIA will be available soon. To register your interest please view our dedicated SPLA2-IIA page.
Measurement of Uncertainty Educational Guide
Measurement of Uncertainty relates to the doubt that exists for the result of any measurement. For every measurement there is always a margin of doubt and therefore we need to ask ‘How big is the margin?’ and ‘How significant is the doubt?’.
In a hospital or healthcare environment, the clinician must be certain that any change identified in a patient’s test results is not a change to the laboratory test system but a change to the patient’s status. This is especially critical at clinical decision levels. Randox Quality Control has developed a guide to Measurement of Uncertainty in response to the demand for more information on the topic within the industry. This guide outlines what Measurement of Uncertainty is, how to measure uncertainty, factors which affect uncertainty and it’s sources.
Request your copy today!
Hearing Loss Linked with Common Household Products, Study Finds
Hearing loss is often associated with old age, tinnitus or balance disorders. However, studies show that anyone can be affected by hearing loss, at any age if exposed to a chemical present in many common household products.
Chances are, you take your senses for granted. Associated generally with deterioration in old age, we never assume we will go deaf or blind in our younger years. Nevertheless, approximately 3 million children in the USA suffer from hearing loss and this number is on the rise. (CHC, 2016)
In 2006, a study was released detailing the mysterious premature hearing loss of a collection of employees in a manufacturing site in Taiwan, specialising in adhesive materials. Chang, Chen, Lien, and Sung narrowed the phenomenon that was the loss of the worker’s auditory sense down to the responsibility of one chemical: Toluene.
Chemical-induced hearing loss, also known as “ototoxicity”, can affect anyone of any age and today, there are over 200 known ototoxic medications on the market known to cause damage to the inner ear containing chemicals largely known to induce ototoxicity such as Syrene and Xylene.
However, sold in many high-street shops, you’ll find the biggest player in the cause of ototoxicity: Toluene. Toluene is a major component of paints, varnishes, petroleum, printing inks, degreasers, adhesives, cigarette smoke, glues, thinners, and plastics. Exposure to Toluene, such as inhalation, ingestion or skin contact, is known to cause not only hearing loss, but commonly can be a factor in causing Tinnitus, Dermatitis, and vision impairment. In general, the component can wreak havoc for the central nervous system and prolonged exposure to high concentrations of the colourless liquid may result in loss of consciousness, and may even be fatal.
Wanisiusiow, whose findings were conducted using the RX series’ RX daytona and a Randox creatinine kit stated, “Toluene is undoubtedly one of the most widely used organic solvents in industry.” But how does Toluene do it? Wanisusiow goes on to state, “As far as we know, there are two major mechanisms which might explain toluene-induced hearing loss. Firstly, a poisoning of Deiters and Hensen’s cells, which are both important to maintain the K+ homeostasis in the vicinity of outer hair cells. Secondly, an oxidative cell injury, such as lipid peroxidation.”
An interesting point uncovered in this study is that suffering the severe side-effect of Toluene seems to be species-specific. The original experiment, carried out on rats, displayed expected symptoms of ototoxicity. However, guinea pigs reacted differently. The study speculates: The half-life of toluene is longer in the rat than in the guinea pig. This might be one way to explain the difference in cochlear sensitivity to toluene between rats and guinea pigs but likely not the only one.
So, what is it in the genetic makeup of guinea pigs, that rats do not possess, that could fight the negative effects of Toluene? Could learning what causes guinea pigs immunity be beneficial to our research into hearing loss?
For more, follow the RX series on Facebook, Twitter, Instagram and LinkedIn.
