Colorectal Cancer

–

The KRAS, BRAF, PIK3CA Array

Early Multiplex Detection of Colorectal Cancer from a Single Sample

Individualised treatment based on mutational profiling for metastatic colorectal cancer (mCRC) patients with the discovery of mutant KRAS status and resistance to EGFR antibodies

Detection of BRAF V600E mutation aids targeted drug treatment

Innovative PCR priming technology permits high discrimination between multiple wild type and mutant DNA regions in the KRAS, BRAF or PIK3CA genes

Combination of multiplex PCR and Biochip array hybridisation to enable enhanced specificity

Simultaneously detecting 20 point mutations within the KRAS, BRAF and PIK3CA genes for rapid patient profiling

Suitable for use on the Evidence Investigator, a semi-automated analyser identifying multiple targets in under 3 hours

The Randox KRAS, BRAF, PIK3CA Array is based on a combination of multiplex PCR and biochip array hybridization for high discrimination between multiple wild‑type and mutant DNA regions in the KRAS (mutations in codons 12, 13 and 61), BRAF (V600E mutation) and PIK3CA (mutations in codons 542, 545 and 1,047) genes. Providing there are enough copies of DNA present, ~1% of mutants can readily be detected in a background of wild‑type genomic DNA. A unique primer set is designed for each mutation target (and control), which will hybridize to a complementary discrete test region (DTR) on the biochip array. Each DTR corresponds to a particular mutation target.

Mutations Detectable by KRAS/BRAF/PIK3CA Array

BRAF
Mutation	Base Change
V600E	GTG>GAG

KRAS
Mutation	Base Change
G12A	GGT>GCT
G12R	GGT>CGT
G12D	GGT>GAT
G12C	GGT>TGT
G12S	GGT>AGT
G12V	GGT>GTT
G13D	GGC>GAC
G13C	GGC>TGC
G13R	GGC>CGC
Q61K	CAA>AAA
Q61L	CAA>CTA
Q61R	CAA>CGA
Q61H1	CAA>CAC
Q61H2	CAA>CAT
A146T	GCA>ACA
A146P	GCA>CCA

PIK3CA
Mutation	Base Change
E542K	GAA>AAA
E545K	GAG>AAG
H1047R	CAT>CGT

The Evidence Investigator

Meet the Evidence Investigator

The Randox KRAS, BRAF, PIK3CA array has been developed for the Evidence Investigator, a semi-automated benchtop immunoassay analyser.

This array simultaneously detects 20 mutation points within the KRAS, BRAF and PIK3CA genes. This assay may further aid the selection for CRC patients suitable for EGFR monoclonal antibody therapy. Whilst designed for colorectal cancer, the array has implications for mutation screening in other cancer types.

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Evidence Investigator

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Colorectal Cancer

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The KRAS, BRAF, PIK3CA Array

Early Multiplex Detection of Colorectal Cancer from a Single Sample

Mutations Detectable by KRAS/BRAF/PIK3CA Array

The Evidence Investigator

Meet the Evidence Investigator

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