Colorectal Cancer

The KRAS, BRAF, PIK3CA Array

Early Multiplex Detection of Colorectal Cancer from a Single Sample

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    Individualised treatment based on mutational profiling for metastatic colorectal cancer (mCRC) patients with the discovery of mutant KRAS status and resistance to EGFR antibodies
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    Detection of BRAF V600E mutation aids targeted drug treatment
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    Innovative PCR priming technology permits high discrimination between multiple wild type and mutant DNA regions in the KRAS, BRAF or PIK3CA genes
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    Combination of multiplex PCR and Biochip array hybridisation to enable enhanced specificity

     

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    Simultaneously detecting 20 point mutations within the KRAS, BRAF and PIK3CA genes for rapid patient profiling

     

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    Suitable for use on the Evidence Investigator, a semi-automated analyser identifying multiple targets in under 3 hours

The Randox KRAS, BRAF, PIK3CA Array is based on a combination of multiplex PCR and biochip array hybridization for high discrimination between multiple wild‑type and mutant DNA regions in the KRAS (mutations in codons 12, 13 and 61), BRAF (V600E mutation) and PIK3CA (mutations in codons 542, 545 and 1,047) genes. Providing there are enough copies of DNA present, ~1% of mutants can readily be detected in a background of wild‑type genomic DNA. A unique primer set is designed for each mutation target (and control), which will hybridize to a complementary discrete test region (DTR) on the biochip array. Each DTR corresponds to a particular mutation target.

Biochip

Mutations Detectable by KRAS/BRAF/PIK3CA Array

BRAF
MutationBase Change
V600EGTG>GAG
KRAS
MutationBase Change
G12A GGT>GCT
G12R GGT>CGT
G12D GGT>GAT
G12C GGT>TGT
G12S GGT>AGT
G12V GGT>GTT
G13DGGC>GAC
G13C GGC>TGC
G13R GGC>CGC
Q61K CAA>AAA
Q61LCAA>CTA
Q61R CAA>CGA
Q61H1 CAA>CAC
Q61H2 CAA>CAT
A146T GCA>ACA
A146PGCA>CCA
PIK3CA
MutationBase Change
E542K GAA>AAA
E545K GAG>AAG
H1047R CAT>CGT

The Evidence Investigator

Meet the Evidence Investigator

The Randox KRAS, BRAF, PIK3CA array has been developed for the Evidence Investigator, a semi-automated benchtop immunoassay analyser.

This array simultaneously detects 20 mutation points within the KRAS, BRAF and PIK3CA genes. This assay may further aid the selection for CRC patients suitable for EGFR monoclonal antibody therapy. Whilst designed for colorectal cancer, the array has implications for mutation screening in other cancer types.

 

Evidence Investigator

Want to know more?

Contact us or visit our Investigator Webpage

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