New findings show antimicrobial resistance on the rise
New findings show antimicrobial resistance on the rise
New antimicrobial resistance findings released by the European Centre for Disease Prevention and Control (ECDC) and the European Food Safety Authority (EFSA) have reported that antimicrobials used to treat diseases can be transmitted between animals and humans. The report presents data from 28 European Union (EU) Member States on humans, pigs, and calves under one year old.
Discussing the report, Poultry World documented that resistance to fluoroquinolones is now so high in Campylobacter bacteria that these antimicrobials no longer work for treatment of severe cases. Studies found that in Campylobacter, extremely high proportions of bacteria were resistant to ciprofloxacin and tetracyclines.
Despite the increase of antimicrobial resistance, Member States that have implemented stringent policies are noteworthy examples for other countries. Broiler farms in the United Kingdom (UK) reduced their antibiotic use by 82% between 2012 and 2017, producing half the meat eaten in the UK and using less than 9.7% of the total antibiotics licensed for food-producing animals.
In the UK, the poultry industry set up the Antibiotic Stewardship group in 2011 to tackle antimicrobial resistance and pre-empt the need for new laws. Coordinated by the British Poultry Council (BPC), participants worked together, shared industry data, and managed a 40% reduction of antibiotic use between 2016-2017. Fluoroquinolone use alone reduced by 91% in the UK. On-going work is to continue in order to improve antimicrobial use, with better data collection and advanced rapid testing methods for antimicrobial sensitivity.
Randox Food Diagnostics recognise the need for antimicrobial detection by providing reliable and economical testing methods to monitor multiple residues from a single sample with Biochip Array Technology. With the Antimicrobial II Array Plus, Randox Food Diagnostic’s offer the detection of 6 classes of antimicrobial compounds including quinolones and tetracycline from urine and tissue samples. Additionally, our tetracycline sensitive and quinolones ELISA kits rapidly uncover additional analytes, with excellent sensitivity levels.
For more information please contact us at info@randoxfooddiagnostics.com
Or visit the meat and seafood section of our website at www.randoxfood.com
Randox Careers Launch Brand New Email Newsletter
Randox Careers has launched a brand new email newsletter for prospective placement students and employees.
The new service will provide subscribers with the latest career roles at Randox in a variety of fields – from science, IT and engineering to manufacturing and marketing. It will also highlight new opportunities in Randox globally – in the UK, Ireland and the rest of world.
Also featured will be the latest news stories from the company, along with Randox’s We Are Randox articles which highlight the personal milestones and professional achievements of current employees.
Click here to sign up to the brand new Careers email newsletter and stay up-to-date with all our Careers news!
Or for further information please email the Randox PR team by emailing randoxpr@randox.com, or phoning 028 9442 2413
Tim Cogley Foundation and Randox Health partner with Liverpool universities to bring cardiac health awareness to the city
An event on preventative healthcare and cardiac screening is being delivered in Liverpool this week by a wealth of world-leading industry and academic speakers.
Hosted by the sponsor of the Randox Health Grand National, in association with Liverpool John Moores University, Liverpool Hope University and the Tim Cogley Cardiac Screening Foundation, the event, entitled the Preventative Cardiac and Metabolic Health Seminar, runs on Wednesday 3rd April and is open to the public.
It follows a morning of engaging fitness programmes, including boxing, taekwondo and indoor cycling, for local pupils and teachers from across Merseyside and Cheshire. During these exercises, which will also include the opportunity to experience life as a jockey by having a go on a horse simulator, the children will also have some physiological measurements taken, including their heart rate.
“Prevention is always better than cure”, says Managing Director Dr Peter FitzGerald. “Our aim is to empower people to take control of their health, to live longer and more healthy lives.
“We are delighted to be teaming up with Liverpool John Moores, Liverpool Hope and the Tim Cogley Cardiac Screening Foundation ahead of the Randox Health Grand National. The world’s greatest race offers us the perfect platform to spread our message of preventative health, and we look forward to sharing our knowledge with the audiences at this exciting event.”
This is the third year that the educational event from Randox Health has been held in the city, and for the second time will be championed by Frank Cogley of the Tim Cardiac Screening Foundation, whose son suffered a fatal heart attack due to a genetic condition. Frank is now working to raise the profile of cardiac health checks for young people.
He commented;
“It’s been recently reported that at least 12 under-35s die from undiagnosed heart conditions every week in the UK. The current lack of routine screening of 18 to 40-year-olds leaves a gaping chasm in our healthcare provision.
“With our highly motivated partners, through events like this, we hope to redress this through lifestyle changes and preventative medical programmes.
“The Tim Cogley Cardiac Screening Foundation is committed to delivery positive, action-focused and life-changing programmes. I can’t imagine a legacy more in tune with the generous, kind and supportive person that was Tim.”
Tickets for the Randox Health seminar, which focuses on health screening and how the right approach can deliver significant benefits, are priced at £3 and are available at https://www.eventbrite.co.uk/e/preventative-cardiac-and-metabolic-health-seminar-tickets-59041545853?aff=ebdshpsearchautocomplete
£2.27 of each ticket payment will go towards the ‘Tim Cogley Cardiac Screening Foundation’ charity. Each attendee at the event will also be entered into a raffle on the day, with the winning prize being general admission tickets for the Randox Health Grand National on Saturday 6th April.
For further information please contact the Randox PR team by emailing randoxpr@randox.com or phoning 028 9442 2413
Randox Sepsis innovation hailed by Health Secretary Matt Hancock
An innovative new tool for quickly diagnosing the often deadly infection Sepsis, will save lives, the Health Secretary has said.
The bedside test, being developed by healthcare diagnostics company Randox, will slash the 24 hours usually taken to identify the correct antibiotic for sepsis treatment. Currently, more than a third of those with sepsis die. Every hour that patients are not diagnosed increases the chance of death by 8%.
Health Secretary Matt Hancock said: “Instead of having to give people huge amounts of antibiotics across the board, which causes other problems, both medical and problems with resistance and super bugs, instead we will be able to work out exactly what the right treatment is for that individual person and do it fast enough to get the treatment in to save lives.”
He paid a visit to Randox’s new headquarters, the Randox Science Park, in Antrim, Northern Ireland on Thursday 21st March.
He added: “I can see a very clear application across the health service for how we can use the technology that is being developed here in Northern Ireland, both across the UK and indeed around the world.”
Sepsis can develop from infections caused by a simple cut or minor medical procedure. The body’s white blood cells fight the infection but the reaction can escalate and also damage healthy tissue.
Many who survive face amputations because of this tissue damage, Randox’s Molecular Diagnostics Manager Dr Martin Crockard said.
Dr Crockard highlighted that the traditional sepsis testing method, which involves sending blood samples to laboratories, takes too long. The problem is worsened by the fact that doctors are then forced to initially prescribe broad spectrum antibiotics which are not specific enough for individual patients. This encourages resistant strains.
To speed up the process, the new technology from Randox’s Biosciences division will allow clinicians in hospital emergency departments to check multiple samples simultaneously, at the press of a few buttons on a smart pad.
Dr Crockard said it is imperative that appropriate antibiotic treatment is administered as quickly as possible.
He said: “We can deal with the exact organism causing the problem in less than four hours, allowing you to tailor the treatment for that individual patient very quickly.”
The UK Sepsis Trust’s Chief Executive Ron Daniels said: “Randox is leading the way around molecular technologies.
“No other system brings this so close to the clinician on the shop floor.”
For further information please contact the Randox PR team by emailing randoxpr@randox.com or phoning 028 9442 2413
Kidney Testing on the Randox Biosciences Evidence Series
March is National Kidney Month, a full month dedicated to raising awareness about kidney disease.
There are two kinds of kidney disease; Chronic Kidney Disease (CKD) and Acute Kidney Injury (AKI).
Chronic Kidney Disease (CKD) affects 3 million people in the UK1. Chronic Kidney is defined as a condition that causes damage and stress on the kidneys, therefore decreasing the ability to keep your body healthy.
The kidneys play a vital role of removing any waste and extra water from the blood to form urine. The kidneys also make hormones that help control your blood pressure, make red blood cells, and keep your bones strong and healthy.2
It is crucial to look after your kidneys. If kidney disease gets worse, the excess waste can build to high levels in your blood, resulting in complications such as high blood pressure, anemia, weak bones, poor nutritional health and nerve damage, as well as increasing the risk of developing heart and blood vessel disease.
Chronic Kidney Disease if often caused by diabetes or having a high blood pressure, which can both be prevented by early detection and treatment. Without treatment the kidney disease will worsen resulting in kidney failure which requires dialysis or a kidney transplant to maintain life.
Chronic Kidney Disease I:
- Fatty Acid Binding Protein I – FABPI
- Soluble Tumour Necrosis Factor Receptor I – sTNFR I
- Soluble Tumour Necrosis Factor Receptor II – sTNFR II
- Macrophage Inflammatory Protein Iα – MIP-Iα
- Interleukin-8 – IL-8
- Epidermal Growth Factor – EGF
- D-Dimer
Chronic Kidney Disease II:
- Complement C3a Des Arginine – C3a des Arg
- C-Reactive Protein – CRP
- Neutrophil Gelatinase Associated Lipocalin – NGAL
- Cystatin C
Acute Kidney Injury (AKI) is when your kidneys stop working properly. This is caused by reduced blood flow to the kidneys, which often happens as a complication of another serious disease.3 AKI affects one in five people admitted to hospital as an emergency, and is considered deadlier than a heart attack 2.
AKI can be reversible if found and treated quickly. Therefore, it is important, if someone has signs of having AKI, to get it treated promptly. Abnormal levels of salt and chemicals can build up in our bodies which causes organs to fail, resulting in the need for dialysis, or can even cause death. 3
- Osteopontin – OPN
- Serum creatinine – Creatinine
- Serum cystatin-C – Cystatin-C
- Kidney injury Molecule-I – KIM-I
- Urinary neutrophil gelatinase associated lipocalin – NGAL
The Evidence Series of Immunoassay analysers contains four revolutionary Biochip Array Technology platforms including the Evidence, Evolution, MultiSTAT and the Investigator.
Randox’s renal panel is available on our Evidence Investigator Immunoassay Analyser, which is a multiplex testing platform allowing for the simultaneous quantitative or qualitative detection of a wide range of analytes from a single sample. It provides a unique platform for assessment of biological samples in a rapid, accurate and easy-to-use format.
For more information on any of the Evidence Series analysers, please visit https://www.randoxbiosciences.com/ or contact us at info@randoxbiosciences.com
- https://www.kidneycareuk.org/news-and-campaigns/facts-and-stats/
- https://www.niddk.nih.gov/health-information/kidney-disease/kidneys-how-they-work
- https://www.nhs.uk/conditions/acute-kidney-injury/
National Brain Awareness Week 11th – 15th March 2019
This year, National Brain Awareness Week runs from the 11th onto the 15th March 2019; a full week dedicated to brain health to increase public awareness of the progress and research of brain health.
Every single brain is unique and therefore, there are no two brains that are alike. The brain is an incredible and powerful organ which works throughout your life – starting from the womb to the end. It controls your body functioning in response to processing new information, developing new experiences and allowing you to understand and interact with the world. It contains one hundred billion nerve cells or neurons and each of the neurons can contact thousands of other cells via tiny structures called synapses. Our brains form a million new connections for every second of our lives.1
There are many conditions which can affect the brain including brain injuries, cerebrovascular injuries such as strokes or brain tumors, neurodegenerative disorders such as dementia or Parkinson’s disease, or even psychological conditions.
There is increasing evidence that the choices we make in life can have significant impacts on the health of our brain and bodies as we grow older. Doctors and scientific researchers have discovered that it’s possible to improve brain health and reduce the risk of dementia and age-related cognitive decline by making simple yet small lifestyle changes – for example, improving your physical exercise.
Physical experience is not only good for the heart but also has a positive impact on the brain as well. People who exercise regularly have a lower risk of developing Alzheimer’s disease as exercise improves blood flow and memory. Another way to improve your brain health is to get your eight hours of sleep. Poor sleeping patterns can increase your chances of developing the brain conditions highlighted above. Also, eating well and eating foods that improve brain function will go a long way – for example, berries, fish, turmeric, green tea, avocado, walnuts and even dark chocolate.
Caroline Abrahams, Director of Age UK said: ‘The changes that we need to make to keep our brains healthy are already proven to be good for the heart and overall health, so it’s common sense for us all to try to build them into our lives.’ 3
Randox Biosciences offers the Apolipoprotein E4 (ApoE4) Array. The Apolipoprotein E4 (ApoE4) Array is a research use-only product developed for the Evidence Investigator. The ApoE4 Array measures both total ApoE protein levels and ApoE4 protein levels directly from plasma samples and by using a ratio it can classify patients as negative or positive for ApoE4. In turn we can then assess their risk for the development of Alzheimer’s disease.
For further information about the Randox Alzheimer’s Array or our Evidence Investigator, please email info@randoxbiosciences.com
We Are Randox | Lauren Todd shortlisted in Ulster University Placement Awards
Randox is a placement-friendly business and we’re proud to be a top employer when it comes to students searching for their perfect placement opportunity before final year. Ulster University Business Studies student Lauren Todd joined the Randox sales team in September 2017 as a placement student, finishing with us in June 2018.
We were delighted to attend a ceremony at Ulster University’s Jordanstown campus last week where Lauren was shortlisted for a UU Placement Award. We caught up with her after the ceremony;
Lauren, congratulations on your award! Can you tell us about your university and career path to date?
During my first two years of university, I worked in retail as a cash office supervisor before leaving in the summer of 2017 to start into my placement year at Randox. I am now in my final year at UUJ and working as a private tutor to A-Level Business Studies students.
Why Randox and how did you find your placement year?
Randox is a globally recognised company with a very close links with Ulster University, and I wanted to complete my placement year with a company that would help me develop my skills outside of the classroom. I thoroughly enjoyed my placement year at Randox and it has allowed me to improve my ‘soft’ skills such as communication, teamwork and problem solving.
What was a typical day like for you at Randox?
A typical day at Randox consisted of daily communication with the global sales team, continual analysis of CRM data and the teams sales figures, compiling reports and providing feedback to the team.
How are you finding being back in university for final year?
Final year has been tough, but it’s scary that we only have six weeks left! My placement year at Randox has enabled me to become a more confident individual, and this has helped with final year projects such as group tasks and class presentations.
What was the award that you were presented with today and how are you feeling about it?
I was commended in the Excellence in Employability Awards from the Ulster University Business School. I am proud to have been shortlisted for this award as Randox have allowed me to develop my skills and helped me to work to my full potential. It feels amazing to gain this recognition from Ulster and that my contribution to the company has been beneficial.
What are your plans for after you leave university?
After graduation, I am looking forward to a few weeks off – and a much-needed two week holiday to Portugal – before starting into a full time graduate job.
To find out more about placement opportunities with Randox, please contact recruitment@randox.com.
How can a policy form the basis of workplace drug & alcohol testing?
If you work in a company with safety-critical roles it is more than likely that you have some sort of workplace drug and alcohol testing policy in place. Even companies without safety-critical roles are implementing these policies to further ensure the health, safety and well-being of their staff.
Employers hold the responsibility to ensure employees are fully aware of the company’s rules, regulations, testing and disciplinary procedures. The policy itself holds vital importance, providing employees with the knowledge of the standards expected of them, whilst educating themselves with information provided in a written comprehensive manner.
The importance of implementing a policy
The most important element of a workplace drug and alcohol testing policy is SAFETY. Drug and alcohol use increases the probability of workplace accidents occurring. Studies have found that employees who have alcohol problems are 2.7 times more likely to have an accident whilst at work. The main issues associated with substance misuse relate to:
- Absenteeism – it’s estimated that 17 million days of work are lost per year due to substance misuse.
- Low productivity levels – employees may reduce output in different tasks and become demotivated.
- Inappropriate behaviour – some cases of substance abuse may lead to crime.
- Aggressive behaviour towards others – resulting in loss of employment / convictions.
It’s evident that many who suffer from drug & alcohol abuse are in employment. Studies show 25% of those in employment were registered drug addicts with 3.3% of all adults aged 16-59 classified as frequent users.
Significant issues such as these provide growing concerns for employers to implement a workplace drug and alcohol policy, to ensure the welfare of each member of staff is considered. Under the Health & Safety Act 1974, employers have a responsibility to ensure the safety of their employees is fully met in order to maintain standards.
The importance of a workplace policy for drugs and alcohol can benefit employers by:
- Building relationships with employees by showing there is help and support available.
- Policies can raise awareness of issues in the business and can encourage staff members to take action if needed.
- It can reduce the number of sick employees, reduce staff turnover and increase productivity levels.
New Donegal Connect launched
A new and ambitious initiative to reach out to all Donegal people and all those who have a love and an affinity for Donegal was launched on Friday 1st March at Donegal Airport.
Donegal Connect is a 10 day event which will take place this autumn from 27th Sept to 6th Oct and aims to continue to strengthen links with Donegal people both on the island of Ireland and across the world by reaching out to them and inviting them to come home and connect again with the county.
There will be something for everyone including events focussed on culture and heritage, sport, and music, genealogy, employment and business development opportunities, education and career opportunities, networking events and workshops on the practicalities of relocating or returning to Donegal.
Cathaoirleach of Donegal County Council Cllr. Seamus O’Domhnaill believes that this initiative will be a celebration of all things Donegal saying:
”We in Donegal are very fortunate to live in a county of outstanding beauty and one that offers a unique family friendly lifestyle, a fantastic quality of life, a place where investment and employment opportunities exist and where businesses and employees can successfully operate and compete on a global stage through many of our locally based worldwide employers. Through connecting with our diaspora we want to create mutually beneficial opportunities that build on the success of the work of our Diaspora office”.
Donegal Connect is about enticing people to make the journey back to Donegal to explore the county and find out why it is a great place to visit, to relocate to, to grow up in, to be educated in, to work in, to invest in or to retire in.
An important element of the initiative is the creation of new opportunities for investment, business development and employment. Donegal Connect wants to communicate the message that Donegal is open for business, has lots of employment opportunities and offers a great quality of life.
Donegal has received some impressive accolades over the last few years including being named as the ‘coolest place on the planet’ in 2017 by National Geographic and more recently Donegal Airport being voted the most scenic landing strip in the world. This along with the filming of Star Wars at Malin Head – Ireland’s most northerly point – and the hosting of the Dubai Duty Free Irish Open in Ballyliffin last summer has showcased the splendour of Donegal to the world and putting it most definitely on the map.
Speaking at the launch event, Breid Gallagher of Randox Teoranta in Dungloe, Donegal, said:
“We are tremendously excited for Donegal Connect and to showcase the very best Donegal has to offer. There are certainly fantastic opportunities available here, as evidenced at our state-of-the-art global diagnostic facility at Randox Teoranta. There are amazing career opportunities right on the doorstep here in Donegal and, being in the most beautiful part of the world with quality of life like no other, you couldn’t ask for a better place to ‘live the journey’!”
For more information on Donegal Connect, please visit https://www.donegalconnect.com/ or email RandoxPR@randox.com.
Rare Disease Day: 28th February 2019
28th February 2019
Rare Disease Day: 28th February 2019
Rare Disease Day raises awareness of rare diseases and how patients’ lives are affected. Many rare diseases remain incurable and many go undiagnosed. 1 in 20 people will live with a rare disease at some point in their life and this is why it is so important to raise awareness.1
What is a rare disease?
There is no single definition for a rare disease, as many countries identify them differently. In the United States, the Rare Diseases Act of 2002 defines a rare disease by its prevalence: “any disease or condition that affects fewer than 200,000 people in the United States”. However, the EU defines a rare disease as a condition that affects less than 5 in 10,000 of the population. There are approximately 7000 rare diseases and disorders and 50% of people affected by rare diseases are children.2,3
Hyperlipoproteinemia type III
This rare disease day, Randox will be raising awareness of hyperlipoproteinemia type III. Hyperlipoproteinemia type III, also known as dysbetalipoproteinemia or broad beta disease, is a rare genetic disorder characterised by improper breakdown of lipids, specifically cholesterol and triglycerides. The condition is caused by mutations in the Apo-E gene, however the inheritance of this condition is complicated due to the development of symptoms having to be triggered by a secondary factor to raise lipid levels. These factors include diabetes, obesity or hypothyroidism.
It is unknown exactly what the prevalence of the condition is, but it is estimated to affect approximately 1 in 5,000 – 10,000 of the general population and it has been found that it affects males more often than females, with women rarely being affected until after menopause.4,5
Figure A. Example of cholesterol and lipid build-up [6]
Symptoms
Symptoms for hyperlipoproteinemia type III will vary for each individual and some people may even be asymptomatic. The most common symptom is the development of xanthomas which are deposits of fatty material, the lipids, in the skin and underlying tissue. Xanthomas may appear on the palms of the hands, eyelids, soles of the feet or on the tendons of the knees and elbows.
> Chest pain or other signs of coronary artery disease
> Cramps in the calves when walking
> Sores on toes
> Stroke-like symptoms such as trouble speaking, dropping on one side of the face, weakness in an arm or a leg and a loss of balance6
Complications can arise if the condition is left untreated and these can include: myocardial infarction, ischemic stroke, peripheral vascular disease, intermittent claudication and gangrene of the lower extremities.7
Diagnosis
Although there is no specific diagnostic test for hyperlipoproteinemia type III, diagnosis is based on clinical evaluation and identification of symptoms. Research has indicated that an algorithm comprising a number of dysbetalipoproteinemia indices may be helpful in the diagnosis of the disease. These include:
> Low apolipoprotein B to total cholesterol ratio
> Elevated levels of triglycerides
> Elevated levels of total cholesterol8
Managing the condition
The condition cannot be cured but treatment is to control conditions such as obesity, hypothyroidism and diabetes. Most patients will go through dietary therapy to control their intake of cholesterol and saturated fat. This prevents xanthomas, high levels of lipids in the blood, exercise will also help to lower lipid levels. However, dietary changes may not be effective for some individuals and this is where drugs may be used to lower lipid levels instead.
How Randox can Help
Randox offer a range of routine and niche assays within the lipid testing panel to monitor lipid levels and to identify associated complications. Some of these tests include:
Apolipoprotein B
The Randox Apolipoprotein B tests utilises an immunoturbidimetric method, offers a wide measuring range and is available liquid ready-to-use for convenience and ease of use.
Total Cholesterol
The Randox Total Cholesterol test utilises the CHOD-PAP method and offers an extensive measuring range with a wide range of kits available to suit a wide range of laboratory sizes.
Triglycerides
The Randox Triglycerides test utilises the GPO-PAP method while offering an extensive measuring range with both liquid and lyophilised formats available offering choice and flexibility.
Want to know more?
Contact us or download our Cardiology and Lipid Testing brochure to learn more.
Related Products
Randox Reagents
Resource Hub
Lipid Panel Page
References
[1] Rare Disease Day. What is Rare Disease Day? Rare Disease Day. [Online] 2019. [Cited: February 21, 2019.] https://www.rarediseaseday.org/article/what-is-rare-disease-day
[2] Genetic Alliance UK. What is a Rare Disease? Rare Disease UK. [Online] 2018. [Cited: February 21, 2019.] https://www.raredisease.org.uk/what-is-a-rare-disease/
[3] NZORD. Rare Disease Facts and Figures. NZORD. [Online] 2019. [Cited: February 21, 2019.] https://www.nzord.org.nz/helpful-information/rare-disease-facts-and-figures.
[4] NORD. Hyperlipoproteinemia Type III. NORD. [Online] 2019. [Cited: February 21, 2019.] https://rarediseases.org/rare-diseases/hyperlipoproteinemia-type-iii/
[5] GARD. Hyperlipidemia Type 3. National Centre for Advanciing Translational Sciences. [Online] December 29, 2016. [Cited: February 21, 2019.] https://rarediseases.info.nih.gov/diseases/6703/hyperlipidemia-type-3
[6] Falck, Suzanne. Everything you need to know about hyperlipidemia. Medical News Today. [Online] December 21, 2017. [Cited: February 21, 2019.] https://www.medicalnewstoday.com/articles/295385.php
[7] Medline Plus. Familial Dysbetalipoproteinemia. Medline Plus. [Online] May 16, 2018. [Cited: February 21, 2019.] https://medlineplus.gov/ency/article/000402.htm.
[8] Dysbetalipoproteinemia: Two cases report and a diagnostic algorithm. Kei, Anastazia, et al. 4, s.l. : World Journal of Clinical Cases, 2015, Vol. 3.