Randox celebrates British Science Week 2017
Randox celebrates British Science Week 2017
Randox celebrates British Science Week 2017
Last week was British Science Week 2017, an annual campaign that aims to inspire innovation and celebrate science. To mark the occasion, Randox Laboratories got involved by celebrating the innovation of each Randox product group. The product groups within Randox shared a series of posts, videos and blogs showcasing the #ScienceBehindRandox throughout British Science Week.
Randox
To initiate the Randox British Science Week campaign, Randox shared this video, which highlights the company’s dedication to improving health worldwide. The video provides an introduction about each product group, however throughout British Science Week, each product group has gone into further detail about the #ScienceBehindRandox.
Randox Careers, the RX series, Randox Reagents, Randox Quality Control, Randox Toxicology, Randox Biosciences, Randox Testing Services, & Randox Food Diagnostics all got involved in the British Science Week Campaign. You can read a snippet of each product groups post below, with videos and links to the full content also provided. We hope you enjoy learning about the #ScienceBehindRandox.
Randox – Dedicated to improving health wordwide.
Randox Careers
Joanne Darragh spent some time with Randox Careers to discuss her role as R&D Toxicology Manager.
“Working in this area has been both challenging and exciting as we are at the cutting edge of assay development. We work in a great team and we work along very closely alongside other departments such as Marketing & Sales so that we are in close contact with what the customer needs, which means we are producing relevant tests very quickly and effectively. Every day brings a new challenge.”
– Joanne Darragh, R&D Toxicology Manager
Listen to what Joanne had to say on the video above
Randox RX series
As part of British Science Week, the RX series caught up with Daniel Melly, one of our very talented Mechanical Design Engineers based in Randox Teoranta in Dungloe, Ireland.
Daniel was an integral part of the team involved in the design of our new semi-automated analyser, the RX misano. The RX series asked Daniel a few questions about why Randox created this analyser, the design process involved in creating such a unique system, and what his favourite features are.
“Randox set out in creating the RX misano with the philosophy of supplying the customer with a more modern, reliable, and aesthetically pleasing analyser than those that are currently available on the market. Robust part selection was always at the fore of any design decisions, and we feel that we have delivered on all of these requirements.”
– Daniel Melly, Randox Mechanical Design Engineer
Read the full interview the RX series had with Daniel here
The RX misano is currently unavailable to purchase in Germany
Randox Reagents
One unique test by Randox, adiponectin, is becoming an increasingly significant biomarker for health professionals. Low levels have been linked with several illnesses including metabolic syndrome, cancer and cardiovascular disease.
What is adiponectin?
Adiponectin is a protein hormone produced and secreted by fat cells called adipose tissue. Adiponectin is normally found in relatively high concentrations in healthy individuals. Its role in the body is to regulate the metabolism of lipids and glucose, which influences the body’s response to insulin and inflammation.
At Randox, our R&D Scientists are helping to change healthcare. By investing heavily into research and development to develop unique diagnostics tests, such as the adiponectin test, Randox provide doctors with the ability to identify disease risk sooner- offering the opportunity to prevent illness, rather than the need to find a cure.
Read the full Randox Reagents blog entry here
Randox Quality Control
One Simple Change to Randox Quality Control can save your laboratory time and money.
Randox Quality Control are a world leading manufacturer of true third party controls with over 390 analytes covering Antioxidants, Blood Gas, Cardiac Markers, Routine Chemistry, Coagulation, Haematology, Diabetes, Immunoassay, Immunology, Lipids, POCT, Therapeutic Drugs, Toxicology and Urine Chemistry, providing complete test menu consolidation. Randox Quality Control produces the most consistent material available with the most accurate target values.
Randox Quality Control guarantee to simplify QC practice in any laboratory, just ask one of their 60,000 users worldwide.
Find out more information about Randox Quality Control in the video above
Randox Toxicology
Randox Toxicology provides trusted solutions for the screening for drugs of abuse. With significant reinvestment in Research and Development, we persistently stay ahead of this ever challenging market. Being the first to develop New Psychoactive Substances tests such as fentanyl, bath salts and flakka allows us to maintain our position as a global leader.
Our pioneering technology has created a number of advancements in the field of toxicology. In particular, our patented Biochip Array Technology which can simultaneously screen from a multi-analyte testing platform, achieving a complete immunoassay profile from the initial screening phase.
Read the full Randox Toxicology blog post here
Randox Biosciences
During British Science Week, we are delighted to introduce you to our latest development utilising this technology; our Gastropanel Array,* a multiplex test engineered to diagnose those at risk of developing peptic ulcers and gastric cancer using non-invasive methods.
Our Gastropanel Array encompasses two quantitative assays, a H. pylori assay for the detection of antibodies produced in response to a H. pylori infection, a common cause of gastric cancer1 as well as a 3plex Gastropanel assay, for the detection of pepsinogen I (PGI), pepsinogen II (PGII) and gastrin 17 (G17).
Currently recorded as the world’s 5th most common cancer, the majority of gastric cancer cases are diagnosed after presenting as an emergency, when treatment may be less effective due to the cancer being at an advanced stage, highlighting the need for the availability of diagnostics tests like our Gastropanel Array to enable practitioners to administer prompt treatment and ultimately increase survival rates on a global scale.
Read the full Randox Biosciences blog here
Randox Testing Services
Randox Testing Services have shown how they are at the forefront of continually reacting and developing tests for NPS. NPS (formerley known as Legal Highs) have had devastating effects on users since emerging in the UK in 2008. These substances are highly dangerous and have caused unnecessary deaths. This is due to the effects from different elements used in production. Legislation concerning the substances changed in 2016 with the implementation of the Psychoactive Substance Act.
How have Randox Testing Services implemented change? Find out in the video above
Randox Food Diagnostics
Of the 41 antibiotics that are approved for use in food-producing animals by the FDA, 31 are medically important for human health. Randox Food Diagnostics provides advanced screening solutions for 94% of these antibiotics including beta-lactams, quinolones and tetracyclines, allowing you to ensure the integrity of your end product without compromising quality. Randox Food provides multiplex screening solutions validated across a range of matrices including urine, serum, tissue, milk, honey and feed.
The Evidence Investigator matched with Biochip Array Technology (BAT) provide the end user with fast, reliable results to aid in ensuring your produce is antibiotic free. BAT provides a platform for the simultaneous determination of multiple drug residues from a single sample using miniaturised immunoassays with implications in the reduction of sample/reagent consumption and an increase in the output of test results.
To read Randox Food Diagnostics full blog click here
We hope you enjoyed our informative British Science Week content from each of our Product Groups.
Look out for our Quiz later this week to test your knowledge on the #ScienceBehindRandox
Randox Horse Tales | Katie Walsh on the partnership with Seabass that made her the most successful female jockey of all time
With less than three weeks’ to go before the Randox Health Grand National, we’re really starting to feel the excitement!
Those who’ve ridden over the famous fences at Aintree never forget it. The most successful female jockey of all time, Katie Walsh, shares her memories of Seabass in the 2012 Grand National, when she came third.
I remember every single bit of it. You don’t forget things like that.
It was a fantastic time and I had some brilliant months in the lead up to it. I won a couple of good races in the build up to the Grand National.
And for Seabass to be the horse that I rode that day, made it all the more magical. This is definitely at the top of my list.
He’d been trained by my father and we’ve been involved with horses for so long that we know how hard it is to have a horse for the Grand National – things can change every day. It’s like someone saying, “I’m going to be President.” That’s how slim the chances are for it to all work out, so I really appreciate how lucky we were to be there.
Seabass is a gorgeous horse and I absolutely love him.
The biggest difficulty we had was keeping him sound. Seabass was a lovely horse but he wasn’t the easiest to keep sound. You see that a lot in elite athletes – sometimes it’s just incredibly difficult to stay fit. And to be in with a shot of getting into the National, you have to keep a horse high enough in the handicaps so it’s constant work – you’ve got to be really careful what you do and how you treat them.
If you look back at his record, Seabass was off for a couple of seasons simply because he has legs of glass, he’s really fragile. There were many different problems over the years which had to be treated and we did a lot of swimming with him. A lot a lot of work went into minding his legs!
The actual race – I could tell you every moment. It was like a dream, the whole ride was fantastic and everything worked out super! Seabass travelled so well – it was a competitive year that year and on another he might have won.
But I was over the moon when we crossed the line in third.
It meant a lot to people that a female jockey had done so well. It featured heavily in the interviews I did afterwards and still does to be honest.
The whole family were there– Ruby wasn’t actually riding himself that day, he’d had a fall earlier. So they were all watching. We’re a pretty special unit – very close – and they were thrilled for us.
Once it was over though, I went straight into the usual routine. In fact I jumped in the car and went to Newmarket. Life goes on!
But once you’ve achieved something like that in the Grand National life does change. Off the back of it I became an Aintree ambassador which is a huge honour and something that I absolutely love.
I can’t wait for the Randox Health Grand National this year!
For more information about Randox Horse Tales please contact Randox PR on 028 9445 1016 or email RandoxPR@randox.com
Randox Biosciences and Dana-Farber Cancer Institute Celebrate Success of Transatlantic Partnership
Today, Randox Biosciences and Dana Farber Cancer Institute highlighted the milestones achieved during their joint partnership. The collaborative partnership was the focus of the Boston-Ireland Precision Medicine Seminar with partners the City of Boston and the Massachusetts Life Science Center (MLSC).
The City of Boston Office of Economic Development and the Massachusetts Life Science Center are collaborating with Randox Biosciences on an innovative event to discuss the Boston-Ireland linkage in the field of Precision Medicine. The event will build business and science relationships between leading life science organizations. The program will highlight Boston as a global life science hub and illustrate why global leaders like Randox are seeking to build business partnerships in the area.
“Dana-Farber is a world-renowned name in the field of oncology and it is great to be working on this exciting new technology which is being developed in the lab of Dr. Novina.” Marshall Dunlop of Randox Laboratories said.
In the last year, the clinical diagnostics and life sciences provider Randox Laboratories has established a collaborative agreement with Dr. Carl Novina at the Dana-Farber Cancer Institute and Harvard Medical School. The goal of this collaboration is to develop therapeutic antibodies that will be incorporated into a platform technology that can reprogram patients’ immune systems to attack cancers.
“I am excited to work with Randox and use these important antibody technologies to help develop a novel cancer therapy that could potentially make a real difference for cancer patients.” said Dr. Carl Novina, Dana Farber Cancer Institute.
The Randox BioSciences and Dana Farber relationship highlights the close ties between Boston, Massachusetts and Ireland and provides another example of the strengths of Boston and Ireland in the life sciences sector. The life sciences industry continues to thrive all across Boston, from Longwood Medical Area – a world-famous medical campus with over 43,000 scientists, researchers, and staff including over 19,000 students – to the South Boston Waterfront District, the city’s newest cluster of high tech research, development, and manufacturing firms.
The City of Boston Chief of Economic Development John Barros said, “Mayor Martin J. Walsh is proud of Boston’s historic links with Ireland and the diverse economic bridges these links have created today. Within the life sciences alone, our researchers and businesses work together in new ways every day to shape how we treat, cure, and innovate together. By partnering with Randox and other leaders in the field, we continue to tackle global challenges together. Here at the City of Boston, we are committed to maintaining open doors as a global and welcoming city. These international partnerships will continue to play an active role in fostering opportunities for collaboration and growth.”
“Collaboration is the key ingredient that makes Massachusetts the best place in the world to innovate,” said Travis McCready, President & CEO of the MLSC. “It is great to see Randox collaborating with the leading scientists at the Dana-Farber Cancer Institute, toward the development of improved, targeted treatments for cancer patients.”
For more information about the Precision Medicine Seminar in Boston please contact Randox PR on 028 9445 1016 or email RandoxPR@randox.com
Randox Horse Tales | Oliver Sherwood shares his memories of Many Clouds, The People’s Horse
There was only one horse that Oliver Sherwood wanted to write about when he was asked to take part in Horse Tales – his 2015 Grand National winner Many Clouds. He was the horse of a lifetime for the Lambourn-based trainer who was hooked the moment he saw him. Clouds tragically died earlier this year and Sherwood says he misses him every day.
The minute I saw him, I knew there was something special. Of course, we all think that. But there was something about Clouds that I just liked from the start.
I had come to look over Mr Hemmings’ young horses when I first saw Clouds. He was a raw, barely broken three year old, and I saw an individualism about him, a character that appealed. From that moment I wanted to be the one to train him.
I’m sure other trainers saw Clouds’ potential too but every time I went to Mr Hemmings’ place, I’d mention to Mick Meagher, the manager, how much I liked him. However I really didn’t expect to get him, so when Mr Hemmings started allocating his horses and Mick called to say they were sending him to me, I was surprised and delighted.
When we started the serious training, I thought he was above average. You can’t be certain – I’ve seen before how horses show form but then can’t perform on the racecourse. That didn’t happen with Clouds. He won on his debut at Wetherby in February 2012, crossing the line 10-15 lengths in front. Right then I knew my gut had been right – he was going to be special. I started hoping and planning for the Hennessey Gold Cup.
He had a summer holiday after that and thickened out. When he came back, he won a handful of hurdles, and came second in the EDF Final the Saturday before Cheltenham, carrying top weight. We were certain that hurdles would be a stepping stone for him.
He was a natural chaser. In 2014 – 15 he won at Carlisle and then won the Hennessey. The rest is history. He won at Cheltenham in January though disappointed in the Gold Cup. But then he won at Aintree in 2015 and that put him on a different level.
As with so many fairy tales from the National, it was unexpected. I’d thought it was too soon for him, but I was persuaded to give it a go. It was a sensational victory. It was the second fastest time – 8 minutes 56.8 seconds, and he did it with 11 stone 9 pounds – almost the top weight. In fact no other horse had carried a higher weight and won at Aintree since Red Rum in ’74. His jockey – Leighton Aspell – said it was the best ride he’d ever had over the fences.
I was staggered by how worldwide the National is. For many trainers you want to win the Gold Cup, it’s the 100m sprint, but when I was being interviewed for the first time by broadcasters in Australia, the US and Japan after winning in 2015, they saw it as the pinnacle.
One thing is absolutely true though – you’ll never forget it. You try to explain to people who have never had horses – but you simply can’t express the thrill of seeing your horse in your colours pass the finishing post in the lead. It was Sir Fred Pontin trying to get that across to Mr Hemmings that got him into racing in the first place. He’d won with Specify in 1971, and showed Mr Hemmings the trophy. He ended up bequeathing it to him in his will – by which stage Mr Hemmings had already won one himself with Hedgehunter.
God puts you on this planet and you are what you are. Clouds, he was a performer, a competitor. He loved to race. He was a nervous horse, a bit spooky but he got more confident as he grew older. He was the proverbial gentle giant, he always wanted to please. He loved his work, he was always very keen to get out and race. Leighton was the only one who schooled and raced him.
Clouds’ last race was his best ever performance. He won by a head in a photo-finish in the Cotswold Chase at Cheltenham but suddenly suffered a severe pulmonary haemorrhage and despite the best efforts of the team on the course, he died just afterwards.
We’ve been overwhelmed by the reaction from people. There have been over a thousand letters – never mind emails and Facebook messages – from all over the world. My wife has responded to every single one of them. People responded to him- they saw he was a trier and they loved that. People could relate to him – in a way he became the people’s horse.
When he won at Aintree thousands of people came out to see him when he came home. Everyone celebrated his win, and that depth of feeling continues today. Our local open day has been renamed after him, and in the village a bench will be placed in his memory thanks to the local council and the Jockey Club. At a party on Saturday here, we still had kids coming up and asking about Clouds. It’s just staggering the impact he had and the inspiration he gave to so many. I am certain he’s bringing a lot of new people into racing.
He was cremated and his ashes were returned to the Isle of Man where Mr Hemmings lives. His shoes will be mounted on a wooden plaque, and his best races inscribed on it. We’ve still got the plaque which was mounted on his box after the won the Grand National.
I’ll never forget Clouds. He will always be in my memories and those of the whole team here in Rhonehurst. Yet I’m glad he went out on a high. I’d rather that than have him suffer an injury. Death happens to us all – I would love to go as he did.
For more information about Randox Horse Tales please contact Randox PR on 028 9445 1016 or email RandoxPR@randox.com
How Randox R&D Scientists are helping to change healthcare: An introduction to diagnostics for BSW 2017
In celebration of British Science Week 2017, we will be giving you an introduction to diagnostics, and exploring how Randox Scientists are helping to change healthcare.
You may or may not already know that Randox are one of the leading diagnostics companies globally. But what exactly does clinical diagnostics involve? It is one of the fundamental steps of finding out what is wrong with a person when they are ill. Read on to find out a bit more about diagnostics, and how the Randox Reagents R&D Scientists are helping to change healthcare globally!
What is a diagnostic test?
A diagnostic test is any kind of analysis performed on a patient sample (a sample is typically blood, urine or cerebrospinal fluid (CSF)), to aid in the diagnosis or detection of disease. The information found from a test can be used to:
- Diagnose disease
- Assess the extent of damage
- Monitor the effectiveness of treatment
- Confirm a person to be free from disease
Blood flows through all parts of the body, coming into direct contact with every organ and tissue. Therefore a blood sample’s appearance and composition provide important information on what is happening in the various parts of the body!
Examples of substances that may be tested for the blood include proteins, nutrients, waste products, antibodies, hormones, salts, trace elements or vitamins.Ā These are sometimes referred to as āanalytesā, āmarkersā or ābiomarkersā.
This is where reagents come inā¦
A reagent is a substance which is mixed with the patient sample to create a chemical reaction to detect the biomarker.Ā These reactions are analysed by machines known as analysers.
Finallyā¦
Using data gathered from both clinical symptoms and laboratory tests, the doctor will follow a sometimes painstaking process of analysis and elimination to perform a successful diagnosis!
Randox Reagents celebrate World Kidney Day 2017
On 9 March 2017, Randox Reagents are celebrating World Kidney Day! World Kidney Day is a global campaign aimed at raising awareness of the importance of our kidneys to our overall health. It aims to reduce the frequency and impact of kidney disease and its associated health problems worldwide.
This year, the World Kidney Day promotes education on the harmful consequences of obesity and its association with kidney disease, advocating healthy lifestyle and health policy measures that make preventive behaviours an affordable option.
With this in mind, throughout the week we have been sharing on social media some interesting facts on diagnostic tests which can help aid an early risk assessment of kidney disease in obese patients, allowing preventative action to be taken before any serious damage occurs. The tests of focus this week included cystatin C, adiponectin and microalbumin…
Cystatin C
The creatinine test is routinely run for patients who are suspected for deteriorating kidney function, however this test has limitations. Cystatin C is an alternative test, and is particularly useful in patients where creatinine measurements are not suitable e.g. individuals who are obese, malnourished, have liver cirrhosis or reduced muscle mass. Importantly, unlike creatinine, cystatin C does not have a ‘blind area’ – up to 50% of kidney function can be lost before significant creatinine elevation occurs. Cystatin C is extremely sensitive to very small changes in kidney function and is therefore capable of detecting early stage kidney dysfunction. The cystatin C test therefore allows preventative measures to be taken much earlier and before significant kidney function decline.
Adiponectin
There is substantial evidence that excess visceral fat is the main driving force for almost all of the disorders associated with the metabolic syndrome, including CKD.1,2 The adiponectin test from Randox can accurately assess levels of abdominal visceral fat, independent of age, race or fitness level.3,4 Assessing adiponectin, and therefore visceral fat levels, can help assess risk of CKD, as well as a range of other illnesses such as pre-diabetes, CVD and various cancers.
Microalbumin
The microalbumin test detects very low levels of a blood protein called albumin, in urine. The detection of albumin in urine can be an indicator of kidney injury and can result in irreversible damage if left untreated. Low albumin concentrations in the urine are the earliest marker of kidney damage and therefore enable preventative measures to be taken. Microalbumin testing can identify individuals with diabetic nephropathy approximately 5-10 years earlier than proteinuria tests helping reduce the frequency of end stage renal disease.
Both World Kidney Day and Randox are working towards improving healthcare worldwide. With continuous investment in R&D, Randox are helping with the risk assessment and earliest detection of renal function problems. By assessing one’s risk of kidney problems (with the adiponectin test), it can give patients (obese and other) the tools to prevent kidney problems further on down the line. With early diagnosis (through the cystatin C and microalbumin tests) it will be possible to keep kidney problems from getting worse, therefore lowering the number of those diagnosed with CKD worldwide.
For health professionals
If you are a clinician or lab interested in running renal function assays, Randox offers a large range of high quality routine and niche assays including: Cystatin C, Creatinine Enzymatic and Jaffe, Microalbumin, Urinary Protein, Urea, Sodium, Potassium, Albumin, Ammonia, β2- Microglobulin, Calcium, Chloride, Glucose, HbA1c, IgG, LDH, Magnesium, Phosphorus (Inorganic), and Uric Acid. These can be run on most automated biochemistry analysers.
For more information, download our Diabetes Brochure or email reagents@randox.com.
References
- Hall JE, Henegar JR, Dwyer TM, et al. Is obesity a major cause of chronic renal disease?Adv Ren Replace Ther. 2004;11(1):41–54. [PubMed]
- Tchernof A, Després JP. Pathophysiology of human visceral obesity: an update.Physiol Rev. 2013;93(1):359–404. [PubMed]
- Matsuzawa, Y. The role of fat topology in the risk of disease. Int J Obes. 2008;32:s83-s92.
- Frederiksen, L., Nielsen, T. L., Wraae, K., Hagen, C., Frystyk, J., Flyvbjerg, A., Brixen, K. and Andersen, M. Subcutaneous Rather than Visceral Adipose Tissue Is Associated with Adiponectin Levels and Insulin Resistance in Young Men. JCEM, (2009) 94 (10): 4010-4015.
Further reading:
What is Measurement of Uncertainty?
Measurement Uncertainty (MU) relates to the margin of doubt that exists for the result of any measurement, as well as how significant the doubt is. For example, a piece of string may measure 20 cm plus or minus 1 cm, at the 95% confidence level. As a result, this could be written: 20 cm ±1 cm, with a confidence of 95%. Therefore, we are 95% sure that the piece of string is between 19 cm and 21 cm long.
Standards such as ISO 15189 require that the laboratory must determine uncertainty for each test. However, they have not specified how this should be done.
How do we calculate Measurement Uncertainty using QC data?
Employing your QC data to calculate uncertainty makes several assumptions; your test system is under control, the patient samples are treated in the same manner as your controls and gross outliers have been removed. If you choose to use your QC data to calculate this you should ensure that you use a commutable control with a matrix similar to that of a patient sample, with analytes present at clinically relevant levels
To calculate MU, labs must look at the intra-assay precision and inter-assay precision of their test.
Intra-assay precision: Sometimes known as ‘within run’ precision, is where 20 or more replicates of the same sample are run at the same time, under the same conditions (calculated from a single experiment). Intra-assay precision helps to assess systematic uncertainties
Inter-assay precision: Sometimes known as ‘between run’ precision, is where 20 or more replicates are run at different times – e.g. 1 replicate every day for 20 days (can be calculated from routine IQC data). Inter-assay precision can help identify random uncertainties within the test system.
*The Australian Association of Clinical Biochemists (AACB) recommends that at least 6 months’ worth of QC data are used when calculating the inter-assay precision1.
Once the data is collected, you must calculate the standard error of the mean (SEM) of the intra-assay precision (A) and the SD of the inter-assay precision (B) in order to measure the uncertainty (u). Once A and B have been calculated, they need to be squared, added together and the square root of the sum found:
As uncertainty is calculated as SD and 1SD is equal to 68% confidence on a standard Gaussian curve, we can conclude that if we multiply using a coverage factor of 2, we can attain 2SD confidence of 95%. This is known as the Expanded Uncertainty (U):
What is the Advantage of Measurement Uncertainty for a lab?
Labs need to carry out MU as it is a requirement of ISO 15189. It states: “The laboratory shall determine measurement uncertainty for each measurement procedure, in the examination phases used to report measured quantity values on patients’ samples. The laboratory shall define the performance requirements for the measurement uncertainty of each measurement procedure and regularly review estimates of measurement uncertainty”.
MU also helps determine whether the difference between two results is negligible due to uncertainty or significant due to a genuine change in condition of the patient; giving labs a greater confidence in reported results.
How can Randox help?
Our new Acusera 24.7 Live Online software provides automatic calculation of MU, saving valuable time and helping labs meet ISO 15189 requirements with ease.
Contact marketing@randox.com to find out how your lab can benefit from Acusera 24.7 Live Online
Take steps to prevent incorrect patient results by making one simple change
According to the NHS Litigation Authority; in 2015 within the UK alone, £193,680,744.30 was spent on ‘wrong diagnosis’ or ‘failed/delayed diagnosis’ causing huge financial strain and impact on labs.
With approximately 75% of clinical decisions and diagnosis based on laboratory test results. The only way to guarantee a high degree of accuracy is to implement a good Quality Control plan. The importance of this is recognised globally, several bodies exist internationally including ISO (International organisation for standardisation) who have developed a set of guidelines and quality systems to ensure the reliability of laboratory test results.
So what can you do to improve accuracy and reliability?
Choose a third party QC
ISO 151589:2012 Section 5.6.2.2 states that “the use of third party control materials should be considered, either instead of, or in addition to, any control materials supplied by the reagent or instrument manufacturer”.
First Party Controls are those manufactured by the instrument/reagent manufacturer. These controls are optimised specifically for use with the manufacturers test system and therefore will mask a multitude of weaknesses. First Party Controls tend to result in perceived accuracy and a biased assessment of performance.
Third Party Controls on the other hand are designed to be completely independent and are not optimised for use with a specific test or system. Leading manufacturers of third party controls will assign target values based on data collected from thousands of independent laboratories, ensuring the availability of statistically robust multi-method, multi-analyser data. Therefore laboratories using Third Party Controls can be assured of unbiased error detection across multiple platforms.
Randox Acusera is a world leading manufacturer of true third party controls providing a cost effective, high quality solution for any laboratory-regardless of size or budget.
Look out for QC samples with clinically relevant concentrations
ISO 15189:2012 states that ‘The laboratory should choose concentrations of control materials wherever possible, especially at or near clinical decision values, which ensure the validity of decisions made’.
It is important to assess the full clinical range of an assay i.e. the range between the lowest and highest results which can be reliably reported. In order to make sure a laboratory instrument is performing accurately across the full clinical range and in particular at the medical decision level, QC materials that cover low, normal and elevated concentrations should be used.
Due to the superior manufacturing process used by Randox, QC target values consistently cover the MDL of tests. By ensuring the controls in use cover clinical decision levels laboratories can be confident of the reliability and accuracy of the patient results they release.
Opt for a commutable control material
A good QC material has many essential properties but above all, controls must perform consistently and reflect the performance of patient samples – if a control meets these requirements then we can say it is commutable. Having a commutable control would aid in the prevention of incorrect patient results because they replicate the performance of a patient sample and react to the test system in a similar manner. Use of a commutable control will also reduce costly shifts in QC target values when reagent batch is changed.
At Randox we take quality seriously, that’s why all QC products are manufactured to the highest possible standard, delivering controls of unrivalled quality. Designed to be commutable, the Acusera range will ensure accurate and reliable instrument performance while simultaneously helping laboratories to meet ISO 15189:2012 requirements. A good QC process will include the use of Third Party Controls, Clinically Relevant Concentrations and controls which can be described as commutable. By employing Quality Control’s that encompass these traits, a laboratory professional can be certain that they have taken the necessary steps to decrease incorrect results and therefore potential misdiagnosis.
Randox Horse Tales | Mike Hughes and “The Greatest Horse of Aintree”
This week in the third edition of Horse Tales we are thrilled to hear from Mike Hughes, Sports Broadcast Journalist for BBC Radio Merseyside.
Mike talks about Red Rum, “The Greatest Horse of Aintree,” and how the race conditions have changed since the millennium bringing with them the best chasers competing to win the world’s most famous race:
Even a cursory glance down the list of previous Grand National winners will highlight some seriously talented racehorses. Factor in the way the race conditions have changed since the new millennium, not to mention the incredible prize money on offer, then it’s not surprising that the very best chasers around are now competing to win the world’s most famous race.
But whatever the future holds for the race that sits at the centrepiece of the three day Aintree festival, there will only ever be one horse that can lay claim to being “The Greatest” that the famous old course has ever seen.
The Red Rum story is a remarkable one by any sporting standards. His love affair with the Grand National knew no bounds. In 1973 he came from “another parish” to pounce and steal victory on the run-in from Australian wonder horse Crisp. He became a National Hero from that point onwards. He broke the course record that year and the time has only been bettered once since.
Red Rum defended his Grand National title in 1974 with an incredible performance. Under the guidance of Brian Fletcher, he pretty much cruised around Aintree as if he owned the joint. He won the race with a swagger and poise that hasn’t been seen since. It was also an outstanding weight carrying performance. Red Rum was top weight in 1974. No horse carrying top weight has won it since.
In the 1975 & 1975 Grand National’s Red Rum was a gallant second. Firstly running a previous Gold Cup winner L’escargot close and then finishing runner up to the well handicapped Rag Trade.
By the time of the 1977 Grand National surely the passing of the years would diminish the chances of another Aintree ” day to remember” for Red Rum. Despite carrying another welter burden and being now aged 12, he put in yet another display of near faultless jumping over the toughest of fences and delivered another emphatic Grand National success. The only horse to win the race three times.
The courage of the horse is highlighted by the fact that he was engaged to run in the Grand National in 1978, but withdrew on the eve of the race due to a minor injury.
If the romantic notion of a horse who was housed in a stable behind a used car showroom in Southport, isn’t enough to convince you of Red Rum’s place in the pantheon of sporting greats then consider this.
If it wasn’t for Red Rum, then the Grand National as a sporting spectacle beyond compare, would probably not exist.
Red Rum and his loveable and outrageous trainer Ginger McCain began writing folklore history at the very same time that the world’s greatest race was under real threat of losing its Aintree home. The owners of the course in the mid 70’s were The Walton Group, property developers who outlined various proposals for Aintree, none of which would have allowed the Grand National to continue.
Red Rum became the popular galvanising force that made ordinary people take notice of this once a year event again. He was the horse and the story that put the Grand National back on the front pages of the world’s newspapers.
When we remember this year as the fortieth anniversary of Red Rum’s third and final Grand National victory we need also to think back ten years earlier, April 7th 1967. It was the horse’s first ever Aintree appearance, as a two year old in a five furlong flat race. Red Rum was never known for his flat racing pedigree, but this was the day he fell in love with this very special racecourse. He dead-heated for first place.
Red Rum’s record and his place in history means that he really is “The Greatest Horse of Aintree”
For more information about Randox Horse Tales please contact Randox PR on 028 9445 1016 or email RandoxPR@randox.com
We Are Randox | Climbing the career ladder: full time job offer for placement student Glenny
This week we were invited to chat with Glenny Crymble, who works in the purchasing and finance department here in Randox headquarters in Crumlin. Glenny, who came to us last year as a placement student, is now employed by Randox on a part time basis as she works towards her final year studying business studies at Ulster University.
“I first joined Randox in September 2015 when I was looking for a placement opportunity as part of my degree. I heard of Randox through my University and I was able to apply through our careers’ website. It was quite hard to find a placement that was related to what I was studying so I was thrilled when I got an interview for Randox. It’s rare to get such a great opportunity to work within an international company, especially within the diagnostics industry. I know that a lot of my friends were unable to secure a placement which is such a shame because it really gives you a great insight into the working world and is a wonderful opportunity to learn and develop.
“I was a little nervous when I started because it was all quite new to me but I settled in pretty soon. I was originally supposed to be working in the logistics department but I was moved to purchasing which I was really pleased with as this is really where my interests lie. Before I started I was given some training so I was comfortable with what was expected of me. On a day to day basis I was sourcing suppliers, placing orders, putting on invoices, paying invoices, doing stocktakes, forming quotations and responding to email queries and questions.
“I know within some placement opportunities you are mainly shadowing people, but at Randox it’s been really hands on which I have loved and you really get the experience. There is also the opportunity to travel if that interests you. I was offered the opportunity to do a little work in Manchester and other colleagues worked at times in Poland, Korea, India and the USA.
“Purchasing was quite a fast paced environment to be working in especially with the opening of the new state-of-the-art Randox Science Park in the former Massereene Barracks. There were floods of orders coming in from the labs which involved a lot of hard work and great teamwork but it was such a good experience and I really learnt a lot from the people around me. Everybody was really helpful and friendly from the moment I started.
“Now I’m working in the finance department. There is a great atmosphere – everyone gets along with one another and we all have a good sense of humour. It’s an open plan office with lots of windows the whole way around so when I first started they told me they call it the fish bowl office as everyone looks in at us which was quite funny. I am really enjoying it so far and now that I have had experience working in the two different departments I know I prefer the finance side of things. I think it get it from my dad as he’s an accountant and a lot of my family work in finance. My main tasks include working on financial statements, evaluating assets and grant work which involves putting in claims for R&D projects.
“Currently I’m deciding whether or not I want to undertake my accountancy exams to become a chartered accountant. The team have really encouraged me to do so as they have such high aspirations for me so I feel more confident in myself and my manager helped me a lot with my placement report.
“I was delighted when Randox asked me to stay on a part-time basis as an Account Executive after my placement year was up- it was a great surprise. I work two days a week now and Randox are really flexible if there is a day that I can’t work due to university commitments.
“I think my placement year helped confirm that I prefer working in finance and helped me pick my optional modules for final year. I picked accountancy modules including financial sector accountancy and total quality management because I knew from working at Randox that I would enjoy these the most. I think if I hadn’t have got a placement I would have been unsure which avenue of work to go down. My placement also really helped me with my dissertation in terms of financial terminology, balance sheets and financial statements. It was based on the Tesco accountancy scandal which was very interesting.
“I would definitely recommend Randox to other placement students, it’s a great place to work. They also have a graduate program for people who have only just graduated. It is rotational, so if like me, you are unsure which avenue you want to pursue, it allows you to work within the different departments to see which you enjoy the most.
“Each year they hold an awards ceremony for placement students, with the top three placement students from each discipline including science, engineering and business being rewarded for their outstanding contributions. I was lucky enough to be one of the nominees last year. It’s great that the company recognises the work that placement students do and you feel a sense of pride working for Randox.
“Once I graduate in June I am going to continue to work with Randox full time so I am excited to start my career. It’s been a great learning curve, I feel that I have become more confident and I hope that I can continue to learn and develop with Randox throughout my career.”
If you are interested in joining our global team make sure that you check out Randox careers website to see what new opportunities we have for you.
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