High Sensitivity CRP
High Sensitivity CRP
Reagent | High Sensitivity CRP
Powered by BiozKey Benefits of the Randox High Sensitivity CRP
Limited Interference
From Conjugate and Free Bilirubin, Haemoglobin, Intralipid and Triglycerides
Wide measuring range
High Sensitivity CRP assay has a wide measuring range of 0.270 – 10 mg/l which will comfortably detect levels outside of the healthy range
Excellent stability
Stable to expiry when stored at 2-8⁰C
Randox High Sensitivity CRP (Latex Enhanced Immunoturbidimetric)
- Latex Enhanced Immunoturbidimetric method
- Liquid ready-to-use reagents
- Stable to expiry when stored at 2-8⁰C
- Measuring range 0.270-10 mg/l
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| CP3885 | R1 2 x 11ml(L) R2 2 x 11ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is High Sensitivity CRP assay used for?
C-reactive protein is present in serum of normal individuals at levels between 0-5mg/l. Research has indicated that CRP levels, which are within the normal range, can be used in a variety of different population subgroups for the assessment of cardiovascular risk for developing a fatal myocardial infarction. CRP levels within the normal range have been associated with coronary heart disease mortality in high-risk individuals. Elevated serum cholesterol levels, elevated diastolic blood pressure and cigarette smoking indicate high-risk.
A complete clinical history is required for accurate interpretation of CRP levels. CRP levels within the normal range may be affected by a number of different factors and should always be compared to previous values.
Publications
Cardiology Panel
For more information or to view more reagents within the cardiology panel, please click here
HDL Cholesterol
Reagent | HDL Cholesterol
Key Benefits
There are several methods available for measurement of HDL Cholesterol
Including Direct Clearance and Phosphotungstic Acid
Exceptional correlation with standard methods
A correlation coefficient of r=0.99 for the Precipitation and Ultracentrifugation methods, was verified against the CDC reference method
Excellent stability
Stable to expiry date when stored at +2 to +8ºC
HDL Cholesterol-Direct Clearance Method
- Direct Clearance Method
- Liquid ready-to-use reagents
- Stable to expiry when stored at 2-8°C
| Cat No | Size | ||||
|---|---|---|---|---|---|
| CH2655 | R1 6 x 78ml (L) R2 3 x 52ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| CH3811 | R1 3 x 51ml (L) R2 3 x 20ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| CH8033 | R1 4 x 38.2ml (L) R2 4 x 18.2ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| CH8311 | R1 4 x 20ml (L) R2 4 x 9ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Randox HDL Cholesterol Precipitant-Phosphotungstic Acid
- AMP method
- Liquid and lyophilised reagents available
- Stable to expiry when stored at +15 to +25°C
- Wide measuring range of 0.071-23.7 mmol/l
| Cat No | Size | ||||
|---|---|---|---|---|---|
| CH203 * | 4 x 80ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| * CH203 is a precipitant product which can be used alongside the CHOD PAP assays (L) Indicates liquid option |
|||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is the HDL Cholesterol assay used for?
High-density lipoproteins (HDL) are one of the major classes of plasma lipoproteins. They are composed of a number of heterogeneous particles, including cholesterol and vary with respect to size and content of lipid and Apolipoprotein. HDL serves to remove cholesterol from the peripheral cells to the liver, where the cholesterol is converted to bile acids and excreted into the intestine.
Accurate measurement of HDL-C is of vital importance when assessing patient risk from CHD. Direct measurement gives improved accuracy and reproducibility when compared to precipitation methods.
HDL is usually requested with other tests, either with cholesterol or as part of a lipid profile, including LDL and triglycerides. The combination of total cholesterol and HDL is very useful for screening for the risk of heart disease.
Patients at risk include:
-
- Smokers
- Men over 45 years and women over 55 years
- Those with Hypertension (blood pressure 140/90 or higher or if taking medications for high blood pressure)
Publications
- Wallace, J.M.W., et al. Boron supplementation and activated factor VII in healthy men. EJCN 2002, 56(11): 1102-1107
- Joshi, S., et al. Fish oil supplementation of rats during pregnancy reduces adult disease in their offspring. J. Nutr., 2003, 133: 3170-3174
- Ghorbanihaghjo, A., et al. Effect of nandrolone decanoate on serum lipoprotein (a) and its isoforms in hemodialysis patients. Lipids Health Dis. 2004, 3: 16
- Saeed, B.O., et al. Comparison of three homogeneous methods for measuring high-density lipoprotein cholesterol with a precipitation method in diabetic and non-diabetic subjects. Br. J. Biomed. Sci., 2004, 61(4): 194-199
- Nowak, M., et al. Changes in lipid metabolism in women with age-related macular degeneration. Clin. Exp. Med., 2005, 4(4): 183-187
- Moreira Lima, L., et al. Níveis Plasmàticos Elevados de Lipoproteína(a) Correlacionados com a Gravidade da Doenca Arterial Coronariana em Pacientes Submetidos à Angiografia (Increased Serum Levels of Lipoprotein(a) Correlated with the Severity of Coronary Artery Disease in Patients Submitted to Angiography. Arquivos Brasileiros de Cardiologia. 2006, 87(3): 260-266
- Mineo, D., et al. Effects of lung volume reduction surgery for emphysema on glycolipidic hormones. Chest. 2008, 134(1): 30-37
- Bajaj, S., et al. A case-control study on insulin resistance, metabolic co-variates and prediction score in non-alcoholic fatty liver disease. Indian J. Med. Res. 2009, 129: 285-292
- Hossein-nezhad, A., et al. Association of VDR gene polymorphism with insulin resistance in diabetic patients. Iranian Journal of Diabetes and Lipid Disorders. 2009, 143-150
- Komolafe, O.A., et al. Streptozotocin-induced diabetes alters the serum lipid profiles of adult Wistar rats. The internet Journal of Cardiovascular Research 2009, 7(1) doi: 10.5580/2251
- Lim, W,Y.A., et al. Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally administered glycyrrhizic acid-treated rats. Lipids in Health and Disease, 2009, 8: 31
- Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393
- Velasco-Martínez, R.M., et al. Obesity and insulin resistance among adolescents from Chiapas. Nutr. Hosp. 2009, 24(2)
- Eu, C.H.A., et al. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids and Health Disease. 2010, 9: 81
- Mahadik, S.R. et al. Role of adipocytokines in insulin resistance: Studies from Urban Western Indian Population. Int. J. Diabetes & Metab. 2010, 18(9): 35-42
- Wonnacott, K.E. et al. Dietary omega-3 and-6 polyunsaturated fatty acids affect the composition and development of sheep granulose cells, oocytes and embryos. Reproduction. 2010, 139(1): 57-69
- Ganguli, D., et al. Association between inflammatory markers and cardiovascular risk factors in women from Kolkata, W.B, India. Arq. Bras. Cardiol. 2011, 96(1): Epub
- Kojic, Z., et al. Effect of captopril on serum lipid levels and cardiac mitochondrial oxygen consumption in experimentally-induced hypercholesterolemia in rabbits. Physiol. Res. 2011, 60(1): S177-S184
- Srinivasa, G., et al. Comparison between serum insulin levels and its resistance with biochemical, clinical and anthropometric parameters in South Indian children and adolescents. Ind. J. Biochem. 2011, 26(1): 22-27
- Hossein-nezhad, A. et al. Circulating omentin-1 in obesity and metabolic syndrome status compared to control subjects. Endocrinol. Metabol. Syndrome 2012: S1:008 doi:10.4172/2161-1017.S1-008
- Yahaya, N. et al. Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge. Journal of Diabetes Mellitus 2012, 2(1): 1-7
Apolipoprotein B
Reagent | Apolipoprotein B (Immunoturbidimetric)
Key Benefits
Excellent stability
The Randox Apolipoprotein B (Immunoturbidimetric) is stable to expiry when stored at 2-8°C
Liquid ready-to-use reagents
Apolipoprotein B reagent comes in a liquid format which is more convenient, and can also help reduce the risk of errors occurring
Applications available
Applications available detailing instrument-specific settings for a variety of clinical chemistry analysers.
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| LP2117 | R1 4 x 50ml (L) (C) R2 4 x 9ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| LP3839 | R1 4 x 20ml (L) R2 4 x 6ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| LP8008 | R1 2 x 10ml (L) R2 2 x 4ml | Enquire | Kit Insert Request | MSDS | Buy Online |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Apolipoprotein B assay used for?
The B Apolipoproteins are the main form of protein found in Low Density Lipoproteins (LDL). Two forms of APO B are found in humans. APO B is the main cholesterol carrying protein in the blood and is the ligand concerned with the uptake of cholesterol into cells by the LDL-receptor pathway. APO B shows atherogenic signs and is thus useful for the evaluation of coronary risk.
The test is undertaken:
- When the patient has a personal or family history of heart disease and/or high concentrations of lipids in the blood
- To determine the patient’s risk of developing CVD
- To help monitor treatment for hyperlipidaemia
- To help diagnose APO B deficiency
Apolipoprotein B Related Products
Apolipoprotein C-III (Apo C-III) Assay
Reagent | Apolipoprotein C-III (Apo C-III)
An Independent Risk Factor for CVD
Benefits of the Randox Apo C-lll Assay
Immunoturbidimetric method
The immunoturbidimetric method limits interference from Bilirubin, Haemoglobin, Intralipid® and Triglycerides, producing more accurate results.
Exceptional correlation
A correlation coefficient of r=1.00 was displayed when the Randox apo C-III assay was compared to commercially available methods.
Excellent measuring range
The Randox apo C-III assay has a measuring range of 2.06 – 21.7mg/dl for the comfortable detection of clinically important results.
Liquid ready-to-use
The Randox apo C-III assay is available in a liquid ready-to-use format for convenience and ease-of-use.
Dedicated calibrator and controls available
Randox offer dedicated apolipoprotein calibrator and controls for a complete testing package.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox apo C-III assay on a variety of clinical chemistry analysers.
Ordering Information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| LP3865 | R1 2 x 11ml (L) R2 2 x 5ml | Enquire | Kit Insert Request | MSDS | Buy Online |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Clinical Significance
Not only is apo C-III a key regulator in the metabolism of triglycerides, but it is also an independent risk factor for CVD. Not only does apo C-III contribute to CVD through the regulation of triglycerides but also through its direct atherogenic effects, promoting atherosclerosis (fig 1) 1.
Fig. 1. Pleiotropic effects of apo C-III 1
Physiological Significance
Apo C-III is composed of 79 amino acids and has a molecular weight of 8.8kDa. Apo C-III promotes hypertriglyceridemia via several mechanisms. Firstly, like apo C-II, apo C-III also inhibits the activity of LPL, distributing lipid lipolysis. Apo C-III hinders the binding of apolipoprotein B and apolipoprotein E to the hepatic receptors resulting in the delayed catabolism of triglyceride – rich lipoproteins (TRLs). Finally, apo C-III prefers the production and secretion of very low-density lipoproteins (VLDL) in the liver 1.
Useful links
Reagents Home
Apolipoprotein Control
Apolipoprotein Calibrator
IgG
Reagent | IgG
Key Benefits of IgG
Excellent precision
The IgG assay showed a precision of less than 4% CV
Exceptional correlation
The assay showed a correlation of r=0.99 against another commercially available method
Completely automated protocols
Available for a range of analysers
Other features
- Immunoturbidimetric method
- Liquid ready-to-use reagents
- Open vial stability of 28 days at 10⁰C
- Measuring range 1.61 – 56 g/l
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| IG3833 | R1 3 x 20ml (L) R2 3 x 14ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| IG8044 | R1 4 x 10.5ml (L) R2 4 x 4ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is IgG used for?
Measurement of immunoglobulin G is the basis of the serological diagnosis of several infectious diseases. Uses of IgG measurement include diagnosis of infectious and inflammatory diseases, diagnosis of malignancies, to detect the presence of soluble antigens and monitoring therapy in myeloma.
The Randox IgG assay is an immunoturbidimetric end-point method for manual use and on automated analysers. The increase in turbidity in a sample containing human IgG is measured at 340 nm.
Related products
Related Products
Specific Proteins Panel
For more information or to view more reagents within the specific proteins panel, please click here