Haptoglobin
Reagent | Haptoglobin
Powered by BiozKey Benefits
Excellent traceability
Standardised to Certified Reference Material (CRM Da470k/IFCC)
Exceptional correlation
A correlation coefficient of r=0.97 was obtained against another commercially available kit
Excellent stability
Onboard reagent stability of 28 days. Calibration is only required every seven days
Other features and benefits
- Immunoturbidimetric method
- Liquid reagents
- Stable to expiry when stored at +2 to +8°C
- Fully automated applications available for a wide range of clinical chemistry analysers
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| HP3886 | R1 1 x 12ml (L) R2a 1 x 3.2ml R2b 1 x 0.625ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| HP8151 | R1 1 x 12ml (L) R2 2 x 4.2ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Haptoglobin assay used for?
Haptoglobin measurements are used in the diagnosis of haemolytic anaemia and to distinguish it from other types of anaemia. In haemolytic anaemia, haptoglobin levels in the blood decrease significantly. Low levels however may also indicate red blood cell destruction due to sickle cell anaemia or thalassemia. In certain cases of liver disease haptoglobin levels may also be low, as the liver cannot manufacture normal levels of the protein.
As an acute phase reactant haptoglobin levels in the blood are significantly increased in response to infection, inflammation, burns, surgery and trauma. However, haptoglobin is not generally used to diagnose or monitor these conditions.
Publications
Specific Proteins Panel
For more information or to view more reagents within the specific proteins panel, please click here
Complement C4 Reagent
Reagent | Complement C4
Key Benefits of the Randox Complement C4 reagent
Exceptional correlation with standard methods
The Randox methodology was compared against other commercially available methods and the Randox Complement C4 assay showed a correlation coefficient of r=0.98
Wide measuring range
The healthy range for Complement C4 is 7 -49 mg/dl. The Randox Complement C4 assay can comfortably detect levels outside of the healthy range measuring between 2.90 – 152 mg/dl
Excellent stability
Stable until expiry date when stored at +2 to +8°C
Other features of the Randox Complement C4 reagent
- Immunoturbidimetric method
- Liquid ready-to-use reagents
- Stable until expiry date when stored at +2 to +8°C
- Measuring range 2.90 – 152 mg/dl
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| CM3846 | R1 3 x 20ml (L) R2 3 x 6ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| CM8024 | R1 2 x 11.2ml (L) R2 2 x 4.2ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is the Complement C4 assay used for?
What is Complement C4?
The complement system is one of the major mechanisms of innate immunology consisting of more than 30 plasma and membrane-associated serum proteins which evokes cytolytic immune responses to pathogens, including viruses, bacteria, chemical tissue damage and anything that is classified as foreign to the body. The complement system can be activated through three major pathways: classical, lectin or alternative. Once activated, reactions occur for antibody opsonisation (the process by which a phagocyte marks a pathogen for ingestion and elimination) to fight against the foreign bodies. Activation can also occur when the body produces antibodies for its own tissues that it views as being foreign, which is known as an autoimmune disorder.
During the activation process, Complement C4 splits down into C4b and C4a (peptide). C4b acts as an opsonin and remains bound to the complex at the surface of the pathogen which activates the next step of the process. The small peptide, C4a diffuses away and acts as a chemotactic factor and an inflammatory paracrine.
The Randox Complement C4 assay is used for the quantitative in vitro determination of complement C4 concentration in serum. The Randox Complement C4 assay allows for the diagnosis and monitoring of autoimmune disorders associated with abnormal levels of complement C4 including lupus and rheumatoid arthritis (RA). Higher than normal results may be indicative of cancer or ulcerative whereas lower than normal results may be indicative of lupus, hepatitis, or cirrhosis.
Cell-bound levels of processed complement activation products, especially E-C4d (erythrocyte-bound C4) is a biomarker in the diagnosis and monitoring of systematic lupus erythematous (SLE). For more information on SLE, please click here.
Specific Proteins Panel
For more information or to view more reagents within the specific proteins panel, please click here
Complement C3 Reagent
Reagent | Complement C3
Key Benefits of the Randox Complement C3 reagent
Exceptional correlation with standard methods
The Randox methodology was compared against other commercially available methods and the Randox Complement C3 assay showed a correlation coefficient of r=0.98
Wide measuring range
The healthy range for Complement C3 is 58 – 170 mg/dl. The Randox Complement C3 assay can comfortably detect levels outside of the healthy range measuring between 13 – 502 mg/dl.
Excellent stability
Stable until expiry date when stored at +2 to +8°C
Other features of the Randox Complement C3 reagent
- Immunoturbidimetric method
- Liquid ready-to-use reagents
- Stable until expiry date when stored at +2 to +8°C
- Measuring range 13 – 502 mg/dl
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| CM3845 | R1 3 x 20ml (L) R2 3 x 6ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| CM8023 | R1 2 x 11.2ml (L) R2 2 x 4.2ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is the Complement C3 assay used for?
What is Complement C3?
The complement system is one of the major mechanisms of innate immunology consisting of more than 30 plasma and membrane-associated serum proteins which evokes cytolytic immune responses to pathogens, including viruses, bacteria, chemical tissue damage and anything that is classified as foreign to the body. The complement system can be activated through three major pathways: classical, lectin or alternative. Once activated, reactions occur for antibody opsonisation (the process by which a phagocyte marks a pathogen for ingestion and elimination) to fight against the foreign bodies. Activation can also occur when the body produces antibodies for its own tissues that it views as being foreign, which is known as an autoimmune disorder. For more information on autoimmune disorders, please click here
During the activation process, Complement C3 splits down into C3b and C3a (peptide). C3b acts as an opsonin and remains bound to the complex at the surface of the pathogen which activates the next step of the process. The small peptide, C3a diffuses away and acts as a chemotactic factor and an inflammatory paracrine.
The Randox Complement C3 assay is used for the quantitative in vitro determination of complement C3 concentration in serum. The Randox Complement C3 assay allows for the diagnosis and monitoring of autoimmune disorders associated with abnormal levels of complement C3 including lupus and rheumatoid arthritis (RA). Higher than normal results may be indicative of cancer or ulcerative whereas lower than normal results may be indicative of lupus, hepatitis, or cirrhosis.
Publications
Specific Proteins Panel
For more information or to visit more reagents within the specific proteins panel, please click here
Rheumatoid Factor
Reagent | Rheumatoid Factor
Rheumatoid Factor Key Benefits
Exceptional correlation
The Rheumatoid Factor assay showed a correlation of r=0.99 against another commercially available method
Applications available
For a wide variety of clinical chemistry analysers including the RX series
Excellent stability
Stable to expiry when stored at 2-8⁰C
Superior Method
Latex Enhanced Immunoturbidimetric method
Ultimate convenience
Liquid ready-to-use reagents
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| RF3836 | R1 2 x 20ml (L) R2 2 x 8ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| RF8063 | R1 2 x 8.7ml (L) R2 2 x 4.7ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| RF8345 | R1 1 x 11.7ml (L) R2 1 x 5.7ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Rheumatoid Factor assay used for?
Research has shown that both environmental and genetic factors can affect the production of RF with various biological properties. Although they may be found in all immunoglobulin classes, the RF most frequently detected is the IgM type; present in about 75% of adult patients with RA and about 10% of children with juvenile RA. RF have also been observed in the serum of patients with lupus erythematosus, hepatitis, liver cirrhosis, syphilis and various other conditions; but the RF titre is much lower than in RA.
Specific Proteins Panel
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Rapid Tests / Serology Panel
For more information or to view more reagents within the rapid tests / serology panel, please click here
HbA1c
Reagent | HbA1c
HbA1c (Direct)
- Latex enhanced immunoagglutination method
- Liquid ready-to-use reagents
- Stable to expiry when stored at +2 to +8°C
- For use with RX series of clinical chemistry analysers
| Cat Code | Size | ||||
|---|---|---|---|---|---|
| HA8123 | R1 2 x 16.2ml (L) R2 2 x 8.2ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| HA8379 | R1 4 x 12.7ml (L) R2 4 x 6ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| HA4068 | R1 4 x 20ml (L) R2 4 x 8.6ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is HbA1c assay used for?
The concentration of HbA1c in the blood of diabetic patients increases with rising blood glucose levels and is representative of the mean blood glucose level over the preceding six to eight weeks. HbA1c can therefore be described as a long term indicator of diabetic control unlike blood glucose which is only a short term indicator of diabetic control.
It is recommended that HbA1c levels are monitored every three to four months. In patients who have recently changed their therapy or in those who have gestational diabetes it may be beneficial to measure HbA1c levels more frequently, at two to four week intervals.
Diabetes Panel
For more information or to view more reagents within the diabetes panel, please click here
Specific Proteins Panel
For more information or to view more reagents within the specific proteins panel, please click here
Glucose
Reagent | Glucose
Key Benefits
Exceptional correlation
The Glucose assay showed a correlation of r=0.99 against another commercially available method
Excellent stability
Stable to expiry when stored at 2-8⁰C
Flexibility
Liquid and lyophilised reagents available for greater consumer choice
Randox Glucose (GOD-PAP & Hexokinase)
- GOD-PAP and Hexokinase method
- Liquid and lypohilised reagents
- Stable to expiry when stored at 2-8°C
Randox Glucose GOD-PAP
| Cat No | Size | ||||
|---|---|---|---|---|---|
| GL8038 | R1a 4 x 50ml (L) R1b 4 x 0.5ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| GL364 | 10 x 100ml (S) | Enquire | Kit Insert Request | MSDS | Buy Online |
| GL2614 | 2 x 500ml (S) (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| GL3815 | 9 x 51ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| GL8318 | 4 x 20ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option (S) Indicates standard included in kit |
|||||
Randox Glucose Hexokinase
| Cat No | Size | ||||
|---|---|---|---|---|---|
| GL3816 | R1 4 x 51ml (L) R2 3 x 20ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| GL3881 | 4 x 50ml (L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| GL8319 | R1 4 x 20ml (L) R2 4 x 6.5ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Glucose assay used for?
Glucose is the primary source of energy for the body. The body obtains glucose through the digestion of the sugar and starch in carbohydrates. Glucose is vital and interacts with the digestive and endocrine system. Due to this it is imperative to maintain glucose levels within the normal range.
- Bor, M.V., et al. Serum fructosamine and fructosamine-albumin ratio as screening tests for gestational diabetes mellitus. Arch. Gynecol. Obstet. 1999, 262(3-4): 105-111
- Ranganath, L., et al. The effect of circulating non-esterified fatty acids on the entero-insular axis. European Journal of Clinical Investigation. 1999, 29(1): 27-32
- Joshi, S., et al. Fish oil supplementation of rats during pregnancy reduces adult disease in their offspring. J. Nutr., 2003, 133: 3170-3174
- Sánchez-Rodríguez, M.A., et al. Antioxidant capacity in relationship to serum lipid peroxides levels in healthy elderly of Mexico City. 2004, 38(2): 193-198
- Panagia, M., et al. PPAR-α activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am. J. Physiol. Heart Circ. Physiol. 2005, 288: H2677-H2683
- Chen, C-W and Cheng, H-H. A rice bran oil diet increases LDL-receptor and HMG-CoA reductase mRNA expressions and insulin sensitivity in rats with streptozotocin/nicotinamide-induced type 2 diabetes. J. Nutr. 2006, 136: 1472-1476
- Gupta, V. et al. Effect of short term cigarette smoking on insulin resistance and lipid profile in asymptomatic adults. Indian J. Physiol. Pharmacol. 2006, 50(3): 285-290
- Lutoslawska, G., et al. Relationship between fasting insulin resistance index (FIRI) and plasma glycerol and free fatty acid levels in physically active males and females. Biol. Sport 2006, 23: 341-351
- Miyashita, M., et al. Exercise and postpandrial lipemia: effect of continuous compared with intermittent activity patterns. Am. J. Clin. Nutr. 2006, 83(1): 24-29
- Mula-Abed, W-A. S. and Aziz, S.B. Serum fructosamine (glycated protein) and related biochemical parameters during normal pregnancy. JBMS Journal of the Bahrain Medical Society 2006, 18(3): 115-122
- Camarillo-Romero, M.S. et al. Riesgo cardiovascular en trabajadores universiatarios. (Article in Spanish). BioQCliNat. 2007,4(13): 9-15
- Halley Castillo E., et al. Body Mass Index and the prevalence of metabolic syndrome among children and adolescents in two Mexican populations. J. Adolesc. Health. 2007, 40(6): 521-526
- James, A.P., et al. Prior exercise does not affect chylomicron particle number following a mixed meal of moderate fat content.Lipids Health Dis. 2007, 6: 8
- Mineo, D., et al. Effects of lung volume reduction surgery for emphysema on glycolipidic hormones. Chest. 2008, 134(1): 30-37
- Aziz, N., et al. Antihypertensive, antioxidant, antidyslipidemic and endothelial modulating activities of a polyherbal formulation (POL-10). Vascul. Pharmacol. 2009, 50(1-2): 57-64
- Bajaj, S., et al. A case-control study on insulin resistance, metabolic co-variates and prediction score in non-alcoholic fatty liver disease. Indian J. Med. Res. 2009, 129: 285-292
- Chou T-W., et al. A Rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced Type 2 diabetes. J.Clin. Biochem.Nutr. 2009, 45(1): 29-36
- García-Montalvo, E.A. et al. Fluoride exposure impairs glucose tolerance via decreased insulin expression and oxidative stress.Toxicology 2009, 263: 75-83
- Hossein-nezhad, A., et al. Association of VDR gene polymorphism with insulin resistance in diabetic patients. Iranian Journal of Diabetes and Lipid Disorders. 2009, 143-150Kanakkaparambil, R., et al. B-vitamin and homocysteine status determines ovarian response to gonadotropin treatment in sheep. Biol. Reprod. 2009, 80(4): 743-752
- Li, T-L. and Rush, B. The effects of prolonged strenuous exercise on salivary secretion of IgA subclasses in men. Int. J. Sport Exerc. Sci. 2009, 1(3): 69-752
- Mirzaei, K., et al. Variation in the vistafin gene may alter the required dosage of oral antidiabetic agents in type 2 diabetic patients. Iranian Journal of Diabetes and Lipid Disorders 2009, 87-94
- Režen, T., et al. Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers. BMC Genomics. 2009, 10: 384
- Rhodes, P., et al. Adult-onset obesity reveals prenatal programming of glucose-insulin sensitivity in male sheep nutrient restricted during late gestation. PloS ONE 2009, 4(10): e7393
- Sébert, S.P., et al. Maternal nutrient restriction between early and midgestation and its impact upon appetite regulation after juvenile obesity. Endocrinology 2009, 150(2): 634-641
- Usman K, M., et al. Correlation between non-insulin dependent diabetes mellitus and serum sialic acid. Annals 2009, 15(3): 152-154
- Velasco-Martínez, R.M., et al. Obesity and insulin resistance among adolescents from Chiapas. Nutr. Hosp. 2009, 24(2)
- Camarillo-Romero, E., et al. (Article in Spanish). Difficulties in the classification of metabolic syndrome. The example of adolescents in Mexico. Salud Publica Mex. 2010, 52(6): 524-527
- Iffen, T.S. and Usoro C.A.O. The effect of ethanolic extract of Larpotea ovalifolia plants growing in Calabar on antioxidants status of streptozocin induced diabetic rats. Global Journal of Pharmacology 2010, 4(1): 01-05
- Itam, E.H., et al. Haemapoietic and immunological changes in multiple low-dose streptozotocin (MDSTZ) rat models. European Journal of Scientific Research. 2010, 43(2): 283-289
- Mahadik, S.R. et al. Role of adipocytokines in insulin resistance: Studies from Urban Western Indian Population. Int. J. Diabetes & Metab. 2010, 18(9): 35-42
- Akpaso, M.I. et al. Effect of combined leaf extracts of Vernonia amygdalina (Bitter leaf) and Gongronema latifolium (Utazi) on the pancreatic β-cells of the streptozotocin-induced diabetic rats. British Journal of Medicine and Medical Research. 2011, 1(1): 24-34
- Chu, N.F et al. Prevalence and anthropometric risk of metabolic syndrome in Taiwanese adolescents. ISRN Cardiol. 2011, 2011: 743640
- Gupta, V., et al. Association of circulating resistin with metabolic risk factors in Indian females having metabolic syndrome.Toxicol. Int. 2011, 18(2): 168-172
- Singal, S., et al. Is cardiovascular risk more in diabetics because of lower apolipoprotein A1 levels rather than higher Apo B/Apo A1 ratio? Int. J. Biomed. Res. 2011, 2(2): 143-150
- Al-Rejaie, S.S., et al. Immobilization stress-induced oxidative damage and its amelioration with green and black teas. Afr. J. Pharm. Pharmacol. 2012, 6(8): 538-545
- Belaïd-Nouira, Y., et al. Study of lipid profile and parieto-temporal lipid peroxidation in AICI3 mediated neurotoxicity. Modulatory effect of fenugreek seeds. Lipids Health Dis. 2012, 11: 16
- Camarillo-Romero, E., et al. Effects of a physical activity program on markers of endothelial dysfunction, oxidative stress, and metabolic status in adolescents with metabolic syndrome. ISRN Endocrinol. 2012, 2012: 970629
- El-Abhar, H.S. and Schaalan, M.F. Topiramate-induced modulation of hepatic molecular mechanisms: an aspect for its anti-insulin resistant effect. PLoS ONE. 2012, 7(5): e37757
- Gupta, V., et al. Association analysis of 31 common polymorphisms with type 2 diabetes and its related traaits in Indian sib pairs. Diabetologia. 2012, 55: 349-357)
- Hammouda, O. et al. Effect of short-term maximal exercise on biochemical markers of muscle damage, total antioxidant status, and homocysteine levels in football players. AJSM. 2012, 3(4): 239-246
- Hossein-nezhad, A. et al. Circulating omentin-1 in obesity and metabolic syndrome status compared to control subjects.Endocrinol. Metabol. Syndrome 2012: S1:008
- Nagalakshmi, C.S. et al. Exploration of the clinico-biochemical parameters to explain the altered renal mechanisms in gestational diabetes mellitus. J. Clin. Diagn. Res. 2012, 6(3): 369-371
- Odum, E.P. and Wakwe V.C. Plasma concentrations of water-soluble vitamins in metabolic syndrome subjects. Niger. J. Clin. Pract. 2012, 15: 442-447
- Odum, E.P., et al. Antioxidant status of type 2 diabetic patients in Port Harcourt, Nigeria. Niger J. Clin. Pract. 2012, 15: 55-58
- Yahaya, N. et al. Type 2 diabetes with good glycemic control have improved insulin response and lower non-esterified fatty acid level after a meal challenge. Journal of Diabetes Mellitus 2012, 2(1): 1-7
- Ikhlas, K.H., et al. The relation between serum total sialic acid and the presence of metabolic syndrome in type 2 diabetes mellitus. Iraqui J. Comm. Med. 2013, (1): 37-41
- Kazeem, M.I., et al. Protective effect of free and bound polyphenol extracts from ginger (Zingiber officinale Roscoe) on the hepatic antioxidant and some carbohydrate metabolizing enzymes of streptozotocin-induced diabetic rats. Evid. Based Complement. Alternat. Med. 2013: 935486
- Wali, U., et al. Antioxidant status and lipid profile of diabetic rats treated with antioxidant rich locally prepared nutriceutical.IJDD. 2013, 1(2): 033-038
- Yakubu, N., et al. Antioxidant and hepatoprotective properties of tofu (curdle soymilk) against acetaminophen-induced live damage rats. Biotech. Res. Int. 2013, ID 230142
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Standards included in GL364, GL366, GL1021 and GL2614
Diabetes Panel
For more information or to view more reagents within the diabetes panel, please click here
Veterinary Panel
For more information or to view more reagents within the veterinary panel, please click here
Total Antioxidant Status (TAS) Assay
Reagent | Total Antioxidant Status (TAS)
A Marker of Overall Antioxidant Status
Benefits of the Randox TAS Assay
Superior method
The Randox TAS assay utilises the colorimetric method, offering convenience and efficiency in comparison to ELISA technology and produces results in as little as 3 minutes.
Excellent measuring range
The Randox TAS assay is linear up to 2.50mmol/l enabling the comfortable detection of clinically important results.
Lyophilised reagents
Lyophilised reagents offer enhanced stability, reducing wastage.
Standard supplied with the kit
The standard is supplied with the TAS kit, simplifying the ordering process.
Dedicated TAS control available
Dedicated TAS control available offering a complete testing package.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox TAS assay on a variety of clinical chemistry analsyers.
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| NX2332 | 5 x 10ml (S) | Enquire | Kit Insert Request | MSDS | Buy Online |
| (S) Indicates standard included in kit | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Free radicals / reactive oxygen species (ROS) are produced during normal cellular metabolism, however, can have harmful effects. Antioxidants are the first line of defence and are produced by the body to neutralise the harmful effects of ROS, preventing cellular damage 1,2, 3. Measuring total antioxidant status (TAS) can provide information on an individual’s overall antioxidant status, which may include antioxidants not yet recognised or not easily measured. The TAS of a sample is a quantitative measurement of the state of balance of the various components (exerting actions in different way) under specified reaction conditions 4.
Reduced levels of total antioxidant status (TAS) is indicative of oxidative stress and increased susceptibility to oxidative damage 5. Oxidative stress is an imbalance between the ROS and antioxidants in the body, favouring ROS 6. Oxidative stress is associated with several health conditions, including: chronic inflammation, neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease, cancer and CVD 7.
TAS Control
Antioxidants Panel
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References
[5] Young IS. Measurement of total antioxidant capacity. Journal of Clinical Pathology 2001; 54(5): 339.
[6] Dix M. Everything You Should Know About Oxidative Stress. https://www.healthline.com/health/oxidative-stress (accessed 27 February 2020).
[7] Eske J. How does oxidative stress affect the body? https://www.medicalnewstoday.com/articles/324863 (accessed 27 February 2020).
Glutathione Peroxidase (Ransel)
Reagent | Glutathione Peroxidase (Ransel)
A Marker of Oxidative Stress
Key Benefits
Superior method
The Randox Ransel assay utilises the enzymatic method enabling the sensitive and accurate detection of glutathione peroxidase.
Excellent precision
The Randox Ransel assay displayed a within run precision of <4.86% CV.
Excellent correlation
A correlation coefficient of r=0.9829 was displayed when the Randox Ransel assay was compared to commercially available methods.
Dedicated calibrator and control available
Dedicated Ransel calibrator and control available offering a complete testing package.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox Ransel assay on a variety of clinical chemistry analysers.
Ordering Information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| RS504 | 8 x 6.5ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| RS505 | 8 x 10ml | Enquire | Kit Insert Request | MSDS | Buy Online |
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Diagnostic Uses
Glutathione peroxidase (GPx) is a reactive oxygen species (ROS), generated by bodily cells via mitochondrial and enzymatic sources. It is vital that GPx levels are reviewed as it can cause oxidative damage to membrane lipids, proteins and DNA. GPx is an intracellular antioxidant enzyme that enzymatically converts hydrogen peroxide to water (detoxification). Hydrogen peroxidase is vital for the maintenance of normal thiol redox-balance, mitochondrial function, and growth factor-mediated signal transduction. By converting hydrogen peroxidase to water, GPx aids in modulating these processes 1. GPx also contributes to cell signalling and oxidative protein folding 2.
Four of the eight glutathione peroxidases (GPx) are selenoproteins (containing the amino acid form of selenium, Sec) in humans, however, GPx6 is cysteine-containing in rodents, but a selenoprotein in humans, whereas the remaining GPx’s are cysteine containing. Glutathione peroxidase 4 (GPx4) is emerging as one of the most important seleoproteins in mammals and is one of the key regulators of ferroptosis, a form of regulated necrotic cell death 2.
GPx displays an inverse correlation with free radicals and consequently oxidative stress (OS). When GPx activity is reduced, antioxidant protection is impaired, resulting in oxidative damage to the membrane fatty acids and functional proteins, resulting in neurotoxic damage. Decreased GPx activity and OS is implicated in the incidence and progression of several health problems, including: cardiovascular disease (CVD), diabetes, atherosclerosis, neurodegenerative disorders and other chronic conditions 3.
Ransel Calibrator
Ransel Control
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References
Non-Esterified Fatty Acids (NEFA) Assay
Reagent | Non-Esterified Fatty Acid (NEFA)
Non-Esterified Fatty Acid (NEFA): A Marker of Insulin Resistance
Benefits of the Randox NEFA Assay
Exceptional correlation
A correlation coefficient of r=0.98 was displayed when the Randox NEFA assay was compared to commercially available methods.
Applications available
Applications available detailing instrument-specific settings for the convenient use of the Randox NEFA assay on a variety of clinical chemistry analsyers.
Extensive measuring range
The Randox NEFA assay has a measuring range of 0.072 – 2.24mmol/l for the comfortable detection of clinically important results.
Standard supplied with the kit
The Randox NEFA kit includes the standard simplifying the ordering process.
Controls available
Controls available offering a complete testing package.
Excellent precision
The Randox NEFA assay displayed a precision of <5% CV.
Ordering information
| Cat No | Size | ||||
|---|---|---|---|---|---|
| FA115 | R1 3 x 10ml (C) R2 3 x 20ml | Enquire | Kit Insert Request | MSDS | Buy Online |
| (C) Indicates calibrator included in kit | |||||
Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
Non-esterified fatty acids are important metabolites stored in adipose tissue. NEFA turnover is swift, with a plasma half – life of 2 to 4 minutes. The dominant source of NEFA is abdominal subcutaneous fat, with considerably less found in leg adipose tissue and a small proportion found in the intraabdominal adipose tissue. NEFA has been recognised as a vehicle by which triacylglycerol (TG) (stored in the adipose tissue) is transported to its sites of utilisation 1. NEFA has been identified as the major source for skeletal muscle during fasting stages and long periods between meals. Cross – sectional studies have consistently documented that circulating NEFA levels are proportional to body fat storage and demonstrated positive correlations between fasting NEFA levels and obesity, insulin resistance and glucose tolerance 2.
Non-esterified fatty acids concentrations are strongly associated with insulin resistance. In the fasting state, the resistance of adipose tissue to the antilipolytic effect of insulin causes the extensive release of NEFA into circulation. Consequently, elevated NEFA levels exacerbate insulin resistance through diminishing insulin – stimulated glucose intake into the skeletal muscle, directly affecting insulin signalling 3.
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References
Urinary Protein
Reagent | Urinary Protein
Key Benefits
Applications available
For a wide variety of clinical chemistry analysers including the RX series
Strong correlation
The Urinary Protein assay showed a correlation coefficient of 0.9998 against another commercially available method
Standard included in kit
Simplifying the ordering process
Randox Urinary Protein (Colorimetric)
- Colorimetric method
- Liquid ready-to-use reagents
- Stable to expiry date when stored at +15 to +25⁰C
- Applications available
| Cat No | Size | ||||
|---|---|---|---|---|---|
| UP1570 | 3 x 100ml (S)(L) | Enquire | Kit Insert Request | MSDS | Buy Online |
| (L) Indicates liquid option (S) Indicates standard included in kit |
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Instrument Specific Applications (ISA’s) are available for a wide range of biochemistry analysers. Contact us to enquire about your specific analyser.
What is Urinary Protein assay used for?
Determination of Total Protein in urine and cerebrospinal fluid is valuable in the diagnosis of renal and central nervous system disorders respectively. Urinary protein elevations are commonly seen in the following conditions: strenuous exercise, fever and hypothermia, nephrosis and diabetic nephropathy and urinary tract infections. Determination of total protein in cerebrospinal fluid aids in the diagnosis of such conditions as meningitis, CNS tumours and cerebral haemorrhage.
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Standard included in all kits
Veterinary Panel
For more information or to view more reagents within the veterinary panel, please click here