Rapid Diagnosis of Bacterial Meningitis with Vivalytic

Randox Laboratories, in collaboration with Bosch Healthcare Solutions (BHCS) is proud to announce the availability of the new Vivalytic Bacterial Meningitis panel on the Vivalytic platform. This highly advanced multiplex PCR test detects six of the most common bacterial pathogens responsible for meningitis, providing results in under an hour.

Meningitis is a critical medical emergency that requires rapid diagnosis to ensure timely and targeted treatment according to current guidelines (1). Over 2,5 million people are infected globally by meningitis each year, with half of these cases affecting children below the age of 5 (2). Furthermore, 20% of bacterial meningitis cases lead to permanent complications such as hearing loss, seizures or brain damage(3), if immediate treatment is not received, about 50% of cases will be fatal (4).

Enter Vivalytic

With a sample of only 200μl of cerebral spinal fluid (CSF), the Vivalytic Bacterial Meningitis Panel simplifies and accelerates the diagnostic process into 4 simple steps, delivering reliable results within 1 hour to support life-saving clinical decisions with the appropriate antibiotic treatment.

The panel detects key pathogens associated with bacterial meningitis:

Detectable Pathogens
Escherichia coli K1	Neisseria meningitidis
Haemophilus influenzae	Streptococcus agalactiae
Listeria monocytogenes	Streptococcus pneumoniae

The innovative all-in-one Vivalytic cartridge minimises the risk of contamination and reduces hands-on time for laboratory staff. This new panel aligns with our mission to improve patient outcomes and support healthcare providers with cutting-edge diagnostic solutions.

The Vivalytic Bacterial Meningitis panel is CE-marked and available to order. For further information on rapid diagnosis of bacterial meningitis with Vivalytic, please visit https://www.randox.com/vivalytic-bacterial-meningitis/ or contact your Randox representative.

References

Pfister H.-W., Klein M. et al., Ambulant erworbene bakterielle Meningoenzephalitis im Erwachsenenalter, S2k-Leitlinie, 2023, in: Deutsche Gesellschaft für Neurologie (Ed.), Leitlinien für Diagnostik und Therapie in der Neurologie. https://dgn.org/leitlinie/ambulant-erworbene-bakterielle-meningoenzephalitis-im-erwachsenenalter
GBD 2019 Meningitis Antimicrobial Resistance Collaborators. Global, regional, and national burden of meningitis and its aetiologies, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2023 Aug;22(8):685-711
GBD 2019 Diseases and Injuries Collaborators. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020 Oct 17;396(10258):1204-1222. doi: 10.1016/S0140-6736(20)30925-9. Erratum in: Lancet. 2020 Nov 14;396(10262):1562. https://pubmed.ncbi.nlm.nih.gov/33069326/ (retrieved on 12/17/2024)
https://www.who.int/news-room/fact-sheets/detail/meningitis (retrieved on 12/17/2024)

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Vivalytic | Bacterial Meningitis

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Rapid Detection of bacterial pathogens associated with Meningitis

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Qualitative RT-PCR detection of bacterial pathogens associated with Meningitis

Compared to the time-consuming traditional procedures, Vivalytic’s quick turnaround time of less than 1 hour allows for the prompt and specific antibiotic treatment to be initiated immediately

Convenient 4 step process from sample entry to results. Suitable for use in laboratory and non-laboratory settings

Detection from a small CSF sample of only 300μl

Clinical Significance

Bacterial meningitis is an infectious disease characterised by infection and inflammation of the meninges, which leads to significant morbidity and mortality worldwide. Even with early diagnosis and proper treatment, 8-15% of patients succumb to the disease within 24 to 48 hours of symptom onset. While meningitis can affect individuals of all ages, young children face the greatest risk. Newborns are particularly vulnerable to Group B streptococcus, while meningococcus, pneumococcus, and Haemophilus influenzae pose higher risks for young children. Young adults and adolescents are prone to meningococcal disease, whereas the elderly are at a higher risk of pneumococcal disease.

The Vivalytic Bacterial Meningitis panel provides the capability to identify six bacterial pathogens implicated in meningitis from a single test, improving screening processes and lowering costs. With minimal steps from sample collection to result, screening for meningitis on the Vivalytic is the most effective wait to contain and prevent spread, requiring no additional further lab equipment.

Features

Sample Type: Cerebral Spinal Fluid (CSF)

Sample Volume: 300 μl

Detection Method: Real-Time PCR

Time to result: Less than 1 hour

Detectable Pathogens
Escherichia coli K1	Neisseria meningitidis
Haemophilus influenzae	Streptococcus agalactiae
Listeria monocytogenes	Streptococcus pneumoniae

Viral Meningitis (In Development)

Real-time PCR test for the detection of pathogens related to Viral Meningitis – More information to follow

Detectable Pathogens
HSV1/HSV2	VZV
Enterovirus

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Vivalytic Workflow

Intuitive engineering of Vivalytic ensures the analyser is user friendly. The process of patient sample to result comprises a very simple 4 step workflow.

To begin the test, the user scans or enters sample information. The cartridge code is then scanned into the embedded Vivalytic software. The user then adds sample into the dedicated cartridge slot, closes the lid and inserts the cartridge into the Vivalytic.

The touchscreen display will countdown the time remaining to test completion. Results will be displayed on the screen. Multiple Vivalytics can be wirelessly connected allowing the user to control multiple tests at one time all reporting to a master Vivalytic platform.

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