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To find out more about the Interleukin-18 (IL-18) biomarker, enquire now.
Interleukin-18 (IL-18) is a pro-inflammatory cytokine involved in immune activation and regulation. It plays a central role in inflammatory signalling, promoting interferon-gamma (IFN-γ) production and driving immune responses.
IL-18 and Autoimmune & Allergic Disease
Increased IL-18 levels have been reported in autoimmune conditions including systemic lupus erythematosus, rheumatoid arthritis and psoriasis, where levels may correlate with disease activity.
IL-18 is also involved in allergic inflammation and has been associated with asthma, atopic dermatitis and other hypersensitivity disorders. In these settings, elevated levels may reflect ongoing immune activation.
IL-18 and Cardiometabolic Risk
Higher IL-18 concentrations have been observed in obesity, metabolic syndrome and type 2 diabetes. Elevated levels have also been associated with increased risk of coronary heart disease and adverse cardiovascular outcomes.
These findings suggest that IL-18 may reflect underlying systemic inflammation contributing to cardiometabolic dysfunction and vascular disease.
Clinical Relevance
As a key mediator of inflammatory signalling, IL-18 is increasingly recognised as a biomarker of immune dysregulation. Measurement of IL-18 may provide insight into inflammatory activity across autoimmune, allergic and cardiometabolic diseases.